gene

OCLN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OCLN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

859Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

OCLN is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 387 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	OCLN
Full Name	Occludin
Chromosome	5q13.2
Protein Type	Structural Protein
Target Class	Structural Protein
Function	Drugs targeting OCLN would stabilize or enhance tight junction protein interactions, reinforcing the structural integrity of the blood-brain barrier and reducing pathological barrier permeability. ...
Mechanism of Action	Drugs targeting OCLN would stabilize or enhance tight junction protein interactions, reinforcing the structural integrity of the blood-brain barrier and reducing pathological barrier permeability. Therapeutic approaches would involve either direct protein stabilization or indirect modulation of occludin phosphorylation and trafficking to maintain barrier function.
Primary Expression	Brain endothelial cells, Epithelial tight junctions
Druggability	Low (0.32)
Clinical Stage	Approved
Molecular Weight	65 kDa
Amino Acids	522 aa
Pathways	Autophagy, Blood-Brain Barrier, Circadian Rhythm, Immune Response, Innate Immunity
UniProt ID	Q16625
NCBI Gene ID	4950
Ensembl ID	ENSG00000130940
OMIM	602876
GeneCards	OCLN
Human Protein Atlas	OCLN
Associated Diseases	Aging, Als, Alzheimer, anxiety
Known Drugs/Compounds	BENVITIMOD, BYF
Interactions	ABCB1, ABCG2, ACHE, ACTB, Actin, Adiponectin
SciDEX Target	View Target Profile (10 clinical trials)
KG Connections	859 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: OCLN — AlphaFold Q16625 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

OCLN — Occludin

gene · 617 words

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Pathway Diagram

graph TD
    OCLN["OCLN"] -->|"interacts"| CLDN1["CLDN1"]
    OCLN["OCLN"] -->|"interacts"| ZO1["ZO1"]
    OCLN["OCLN"] -->|"interacts"| MLCK["MLCK"]
    OCLN["OCLN"] -->|"co discussed"| APOE["APOE"]
    OCLN["OCLN"] -->|"co discussed"| LRP1["LRP1"]
    OCLN["OCLN"] -->|"co discussed"| LDLR["LDLR"]
    CLDN1_1["CLDN1"] -->|"interacts"| OCLN["OCLN"]
    ZO1_2["ZO1"] -->|"interacts"| OCLN["OCLN"]
    MLCK_3["MLCK"] -->|"interacts"| OCLN["OCLN"]
    CLDN5["CLDN5"] -->|"interacts"| OCLN["OCLN"]
    style OCLN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (505)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:OCLN	data_in	dataset_row	0.00
TIGHT_JUNCTION	participates_in	pathway	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
CLDN5	interacts_with_confidence_0.99	gene	0.99
OCCLUDIN	encodes	protein	0.95
Blood-Brain Barrier	involved_in	process	0.95
BLOOD-BRAIN BARRIER	involved_in	entity	0.95
TIGHT JUNCTION	involved_in	entity	0.95
blood-brain barrier	participates_in	pathway	0.90
Brain Arteriovenous Malformations	biomarker_for	disease	0.90
Cell Migration	inhibits	process	0.88
Cell Proliferation	inhibits	process	0.88
BLC-PMG	causes	disease	0.87
Brain Edema	associated_with	phenotype	0.85
Gut Barrier Dysfunction	involved_in	process	0.85
Immune Response	involved_in	process	0.85
Tight Junctions	involved_in	process	0.85
unfolded protein response	participates_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.80
Cerebral Cortex	expressed_in	brain_region	0.80
LPS-induced lung injury	protects_against	disease	0.80
Brain Arteriovenous Malformations	downregulates	disease	0.80
occludin	encodes	protein	0.80
NEURODEVELOPMENTAL_DISORDER	causes	disease	0.72
VIRAL_ENTRY	regulates	pathway	0.72
HCV	regulates	disease	0.72
KIRC	associated_with	disease	0.72
BARRIER_FUNCTION	regulates	phenotype	0.72
EPITHELIAL_BARRIER	regulates	phenotype	0.72
STING	activates	gene	0.70
STING	expresses	gene	0.70
endothelial cells	expressed_in	cell_type	0.70
autophagy pathway	participates_in	pathway	0.70
Epilepsy	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Hepatitis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Carcinoma	biomarker_for	disease	0.65
Tumor	expressed_in	disease	0.65
Inflammation	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
Cirrhosis	expressed_in	disease	0.65
Ataxia	associated_with	disease	0.65
Anxiety	contributes_to	disease	0.65
Anxiety	activates	disease	0.65
Tumor	regulates	disease	0.65
Als	protects_against	disease	0.65
Als	inhibits	disease	0.65
Ms	protects_against	disease	0.65
Aging	activates	disease	0.65

Incoming (354)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:OCLN	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
Brain Arteriovenous Malformations	downregulates	disease	0.95
Byf	upregulates	drug	0.95
BRAIN ARTERIOVENOUS MALFORMATIONS	downregulates	entity	0.95
Betulinic Acid	upregulates	compound	0.95
KLF11	binds	entity	0.90
Litebamine	upregulates	compound	0.90
h-6c83282d	targets_gene	hypothesis	0.90
h-7a8d7379	targets_gene	hypothesis	0.90
LRWE	upregulates	compound	0.90
miR-193b-5p	inhibits	gene	0.90
Gallic Acid	upregulates	compound	0.88
Ruptured Brain Arteriovenous Malformations	downregulates	phenotype	0.88
DTG	downregulates	drug	0.85
Nobiletin	upregulates	compound	0.85
CLDN1	co_mentioned_with	gene	0.80
Endoplasmic Reticulum Stress	downregulates	process	0.80
h-7a8d7379	targets	hypothesis	0.80
h-6c83282d	targets	hypothesis	0.80
BDNF-TrkB-PLC/IP3 pathway	activates	pathway	0.80
Qingqi Liangying formula	upregulates	drug	0.80
CTNNB1	interacts_with_confidence_0.775	gene	0.78
MIR193B5P	inhibits	gene	0.72
CMVS	activates	protein	0.72
IL4	inhibits	protein	0.72
IL13	inhibits	protein	0.72
BENVITIMOD	activates	drug	0.72
ACHE	markers	gene	0.70
GFAP	activates	gene	0.70
ASTROCYTE	activates	cell_type	0.70
CLDN5	expresses	gene	0.70
ENDOTHELIAL	expresses	cell_type	0.70
GPX4	activates	gene	0.70
CLDN5	co_mentioned_with	gene	0.70
TNF	inhibits	gene	0.64
MSC	activates	cell_type	0.64
BYF	activates	drug	0.64
ATF4	therapeutic_target	gene	0.60
HIF1A	activates	gene	0.60
IL6	inhibits	gene	0.60
BECN1	activates	gene	0.60
CXCL2	inhibits	gene	0.60
ABCG2	activates	gene	0.60
NOS2	activates	gene	0.60
MAP1LC3B	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
CAV1	activates	gene	0.60
GAPDH	activates	gene	0.60
ATF4	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity