concept

TJP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TJP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

202Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

TJP1 is a concept in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with ALS, Als, Ms. Connected to 77 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	TJP1
Key Genes/Proteins	ABCB1, ABCG2, ACTB, Actin, AND, APOPTOSIS
Related Diseases	Als, ALS
Related Pathways	Apoptosis, apoptosis pathway

Pathway Diagram

graph TD
    TJP1["TJP1"]
    TJP1 -->|"activates"| Als["Als"]
    TJP1 -->|"activates"| Stroke["Stroke"]
    TJP1 -->|"regulates"| Ms["Ms"]
    TJP1 -->|"activates"| ALS["ALS"]
    TJP1 -->|"activates"| Autophagy["Autophagy"]
    TJP1 -->|"activates"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    TJP1 -->|"activates"| Proteasome["Proteasome"]
    TJP1 -->|"activates"| Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
    BDNF_TrkB_PLC_IP3_pathway["BDNF-TrkB-PLC/IP3 pathway"] -->|"activates"| TJP1
    BECN1["BECN1"] -->|"activates"| TJP1
    CAV1["CAV1"] -->|"activates"| TJP1
    CLDN5["CLDN5"] -->|"activates"| TJP1
    HIF1A["HIF1A"] -->|"activates"| TJP1
    OCLN["OCLN"] -->|"activates"| TJP1
    ACTB["ACTB"] -->|"regulates"| TJP1
    ENO1["ENO1"] -->|"regulates"| TJP1
    TLR["TLR"] -->|"regulates"| TJP1
    EXOSOMES["EXOSOMES"] -->|"regulates"| TJP1

Outgoing (92)

Target	Relation	Type	Str
h-1e980cc6cb	associated_with	hypothesis	1.00
CLDN5	interacts_with_confidence_0.993	gene	0.99
blood-brain barrier	involved_in	process	0.90
transendothelial electrical resistance	regulates	phenotype	0.85
Brain Edema	associated_with	phenotype	0.85
blood-brain barrier	participates_in	pathway	0.80
Cerebral Cortex	expressed_in	brain_region	0.80
ubiquitin-proteasome	participates_in	pathway	0.70
endothelial cells	expressed_in	cell_type	0.70
autophagy pathway	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
Inflammation	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Stroke	activates	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
Ms	regulates	disease	0.65
Toll-Like Receptor	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Inflammasome	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
WT1	associated_with	gene	0.60
Stem Cell	associated_with	cell_type	0.60
Rb	activates	protein	0.60
blood-brain barrier	expressed_in	brain_region	0.60
Tubulin	associated_with	protein	0.60
Endothelial	activates	cell_type	0.60
TNFA	causes	gene	0.60
Caspase	regulates	protein	0.60
Actin	regulates	protein	0.60
Blood-Brain Barrier	activates	pathway	0.60
Ubiquitin-Proteasome	activates	pathway	0.60
Autophagy	regulates	pathway	0.60
Proteasome	regulates	pathway	0.60
Ubiquitin-Proteasome	regulates	pathway	0.60
STROKE	activates	gene	0.60
CAV1	activates	gene	0.60
CLDN5	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
OCLN	activates	gene	0.60
HIF1A	activates	gene	0.60
BECN1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Fus	activates	protein	0.60
Cerebrovascular	activates	pathway	0.60
Proteasome	activates	pathway	0.60
Raf	activates	protein	0.60
Autophagy	activates	pathway	0.60
CASP3	regulates	gene	0.60
GAPDH	regulates	gene	0.60

Incoming (110)

Source	Relation	Type	Str
MMP-9	proteolytically_cleaves	protein	0.00
h-1e980cc6cb	targets	hypothesis	1.00
CTNNB1	interacts_with_confidence_0.969	gene	0.97
KLF11	binds	entity	0.90
Gallic Acid	upregulates	compound	0.88
DTG	downregulates	drug	0.85
BDNF-TrkB-PLC/IP3 pathway	activates	pathway	0.80
EXOSOMES	regulates	gene	0.60
TRAF6	regulates	gene	0.60
OGT	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
CLDN1	activates	gene	0.60
BECN1	activates	gene	0.60
CAV1	activates	gene	0.60
CLDN5	activates	gene	0.60
HIF1A	activates	gene	0.60
OCLN	activates	gene	0.60
ENO1	regulates	gene	0.60
ACTB	regulates	gene	0.60
TLR	regulates	gene	0.60
RAC1	associated_with	gene	0.60
OCLN	associated_with	gene	0.60
CYP11A1	regulates	gene	0.60
AR	activates	gene	0.60
SCIN	activates	gene	0.60
MCT1	activates	gene	0.60
AQP5	biomarker_for	gene	0.60
INSR	biomarker_for	gene	0.60
FAS	activates	gene	0.60
MUC1	biomarker_for	gene	0.60
OCLN	biomarker_for	gene	0.60
ATG16L1	activates	gene	0.60
ATP	activates	gene	0.60
LC3	activates	gene	0.60
LC3B	activates	gene	0.60
MAP1LC3	activates	gene	0.60
RNA	activates	gene	0.60
SNF	activates	gene	0.60
rapamycin	targets	drug	0.60
LRP1	biomarker_for	gene	0.60
HMGCS2	activates	gene	0.60
P62	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
SCIN	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
VIM	associated_with	gene	0.60
H2AX	regulates	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What blood-brain barrier permeability changes serve as early biomarkers for neur

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.710

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.919

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning TJP1 in their description or question text

No additional research found

TJP1

Understanding Entity Pages

Summary

Pathway Diagram

Outgoing (92)

Incoming (110)

Targeting Hypotheses (0)

Mentioning Analyses (2)

What blood-brain barrier permeability changes serve as early biomarkers for neur

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

Experiments (0)

Related Papers (0)

Debates (3)

What blood-brain barrier permeability changes serve as early biomarkers for neur

Should PEA-PPARA endocannabinoid signaling be prioritized as a therapeutic strat

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

Related Research