protein

CASPASE1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASPASE1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

10Outgoing

0Incoming

0Experiments

0Debates

Summary

Caspase-1 (CASP1)

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🔬 Protein Info

Gene Symbol	CASPASE1
Function	Caspase-1 (interleukin-1β-converting enzyme, ICE) is the prototypical inflammatory caspase, playing a central role in innate immunity and inflammatory cell death (pyroptosis)
Subcellular Localization	Cytosol, inflammasome complex
Molecular Weight	45 kDa (pro-form), 20/10 kDa (cleaved subunits)
UniProt ID	[P29466](https://www.uniprot.org/uniprot/P29466)
GeneCards	CASPASE1
Human Protein Atlas	CASPASE1
IL-33	Processed to active form (context-dependent)
Associated Diseases	ALS
KG Connections	10 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Caspase-1 (CASP1)

protein · 702 words

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Pathway Diagram

graph TD
    CASPASE1["CASPASE1"]
    ALS["ALS"]
    CASPASE1 -->|"associated_with"| ALS
    MAP2["MAP2"]
    CASPASE1 -->|"associated_with"| MAP2
    GSDMD["GSDMD"]
    CASPASE1 -->|"associated_with"| GSDMD
    ASC["ASC"]
    CASPASE1 -->|"associated_with"| ASC
    HMGB1["HMGB1"]
    CASPASE1 -->|"associated_with"| HMGB1
    NLRP3["NLRP3"]
    CASPASE1 -->|"associated_with"| NLRP3
    Ferroptosis["Ferroptosis"]
    CASPASE1 -->|"associated_with"| Ferroptosis
    Apoptosis["Apoptosis"]
    CASPASE1 -->|"associated_with"| Apoptosis
    Pyroptosis["Pyroptosis"]
    CASPASE1 -->|"associated_with"| Pyroptosis
    Neuron["Neuron"]
    CASPASE1 -->|"expressed_in"| Neuron
    neurodegeneration["neurodegeneration"]
    CASPASE1 -->|"implicated_in"| neurodegeneration
    style CASPASE1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
ALS	associated_with	disease	0.65
Ferroptosis	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Pyroptosis	associated_with	pathway	0.60
MAP2	associated_with	gene	0.60
GSDMD	associated_with	gene	0.60
ASC	associated_with	gene	0.60
HMGB1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CASPASE1 in their description or question text

No additional research found