gene

PSD95

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSD95: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

632Connections
2Hypotheses
4Analyses
50Outgoing
50Incoming
1Experiments
5Debates

Summary

PSD95 is a gene implicated in neurodegeneration research. Key relationships include: activates, protects against, treats. Associated with Aging, Als, Alzheimer. Connected to 149 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolPSD95
Full NameDLG4
Chromosome8p12 [@migaud1998]
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
PathwaysApoptosis, Astrocyte Reactivity, Dendritic Spine, Epigenetic, Long-Term Potentiation
UniProt IDP78352
NCBI Gene ID1749
Ensembl IDENSG00000132535
GeneCardsPSD95
Human Protein AtlasPSD95
Associated DiseasesAls, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsCN2097, rapamycin, SYN3
InteractionsACHE, AD, ADAM10, AGING, AKT, ALZHEIMER
KG Connections632 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: PSD95 — AlphaFold P78352 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DLG4 Gene

gene · 1025 words

Pathway Diagram

graph TD
    PSD95["PSD95"]
    BDNF["BDNF"]
    PSD95 -->|"regulates"| BDNF
    Alzheimer{"Alzheimer"}
    PSD95 -->|"expressed in"| Alzheimer
    Dementia{"Dementia"}
    PSD95 -->|"expressed in"| Dementia
    Als{"Als"}
    PSD95 -->|"expressed in"| Als
    Anxiety{"Anxiety"}
    PSD95 -->|"activates"| Anxiety
    Inflammation{"Inflammation"}
    PSD95 -->|"activates"| Inflammation
    Depression{"Depression"}
    PSD95 -->|"activates"| Depression
    PSD95 -->|"activates"| Alzheimer
    Aging{"Aging"}
    PSD95 -->|"activates"| Aging
    PSD95 -->|"activates"| Als
    Ms{"Ms"}
    PSD95 -->|"activates"| Ms
    PSD95 -->|"expressed in"| Ms
    NLGN1["NLGN1"]
    NLGN1 -->|"interacts with"| PSD95
    CN2097["CN2097"]
    CN2097 -->|"interacts with"| PSD95
    SYN3["SYN3"]
    SYN3 -->|"interacts with"| PSD95
    MMP9["MMP9"]
    MMP9 -->|"expressed in"| PSD95
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"expressed in"| PSD95
    RELA["RELA"]
    RELA -->|"associated with"| PSD95
    OPA1["OPA1"]
    OPA1 -->|"expressed in"| PSD95
    P62["P62"]
    P62 -->|"associated with"| PSD95
    MFN2["MFN2"]
    MFN2 -->|"expressed in"| PSD95
    MBP["MBP"]
    MBP -->|"expressed in"| PSD95
    SYN1["SYN1"]
    SYN1 -->|"activates"| PSD95
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| PSD95
    style PSD95 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (323)

TargetRelationTypeStr
Synaptic Plasticityassociated_withprocess0.85
Alsactivatesdisease0.85
Synaptic Functioninvolved_inprocess0.80
Neuronal Damageprotects_againstprocess0.80
Alzheimer's diseaseimplicated_indisease0.80

Incoming (309)

SourceRelationTypeStr
NPFFupregulatesprotein0.90
SYN3interacts_withdrug0.90
CN2097interacts_withdrug0.90
CCL5upregulatesprotein0.88
Copperinhibitscompound0.85

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 0.861 Alzheimer's disease Circuit-level neural dynamics in neurode
Oxygen Pressure-Dependent BDNF Cascade: DHHC2/PSD95 Stabiliz 0.580 neurodegeneration View

Mentioning Analyses (4)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 67 hypotheses Top: 1.000

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.784

APOE4 structural biology and therapeutic targeting strategies

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.795

Experiments (1)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Synaptic plasticity and protein expression analysis in mPFC exploratory insomnia-anxiety comorbidity 0.850 0.00 mPFC brain slices from PCPA-tr proposed N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (5)

Multi-agent debates referencing this entity

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.90 · 2026-04-12

APOE4 differs from APOE3 by C112R causing domain interaction that alters lipid b

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

closed · Rounds: 4 · Score: 0.83 · 2026-04-06

Tau propagation mechanisms and therapeutic interception points

closed · Rounds: 3 · Score: 0.95 · 2026-04-04

Analyze circuit-level changes in neurodegeneration using Allen Institute Neural

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning PSD95 in their description or question text

No additional research found