Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PSD95: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PSD95 is a gene implicated in neurodegeneration research. Key relationships include: activates, protects against, treats. Associated with Aging, Als, Alzheimer. Connected to 149 entities in the SciDEX knowledge graph.
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| Gene Symbol | PSD95 |
| Full Name | DLG4 |
| Chromosome | 8p12 [@migaud1998] |
| Protein Type | Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Pathways | Apoptosis, Astrocyte Reactivity, Dendritic Spine, Epigenetic, Long-Term Potentiation |
| UniProt ID | P78352 |
| NCBI Gene ID | 1749 |
| Ensembl ID | ENSG00000132535 |
| GeneCards | PSD95 |
| Human Protein Atlas | PSD95 |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | CN2097, rapamycin, SYN3 |
| Interactions | ACHE, AD, ADAM10, AGING, AKT, ALZHEIMER |
| KG Connections | 632 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PSD95["PSD95"]
BDNF["BDNF"]
PSD95 -->|"regulates"| BDNF
Alzheimer{"Alzheimer"}
PSD95 -->|"expressed in"| Alzheimer
Dementia{"Dementia"}
PSD95 -->|"expressed in"| Dementia
Als{"Als"}
PSD95 -->|"expressed in"| Als
Anxiety{"Anxiety"}
PSD95 -->|"activates"| Anxiety
Inflammation{"Inflammation"}
PSD95 -->|"activates"| Inflammation
Depression{"Depression"}
PSD95 -->|"activates"| Depression
PSD95 -->|"activates"| Alzheimer
Aging{"Aging"}
PSD95 -->|"activates"| Aging
PSD95 -->|"activates"| Als
Ms{"Ms"}
PSD95 -->|"activates"| Ms
PSD95 -->|"expressed in"| Ms
NLGN1["NLGN1"]
NLGN1 -->|"interacts with"| PSD95
CN2097["CN2097"]
CN2097 -->|"interacts with"| PSD95
SYN3["SYN3"]
SYN3 -->|"interacts with"| PSD95
MMP9["MMP9"]
MMP9 -->|"expressed in"| PSD95
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"expressed in"| PSD95
RELA["RELA"]
RELA -->|"associated with"| PSD95
OPA1["OPA1"]
OPA1 -->|"expressed in"| PSD95
P62["P62"]
P62 -->|"associated with"| PSD95
MFN2["MFN2"]
MFN2 -->|"expressed in"| PSD95
MBP["MBP"]
MBP -->|"expressed in"| PSD95
SYN1["SYN1"]
SYN1 -->|"activates"| PSD95
INFLAMMATION["INFLAMMATION"]
INFLAMMATION -->|"activates"| PSD95
style PSD95 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Synaptic Plasticity | associated_with | process | 0.85 |
| Als | activates | disease | 0.85 |
| Synaptic Function | involved_in | process | 0.80 |
| Neuronal Damage | protects_against | process | 0.80 |
| Alzheimer's disease | implicated_in | disease | 0.80 |
| Als | treats | disease | 0.75 |
| Neurodegeneration | treats | disease | 0.75 |
| BDNF | regulates | protein | 0.72 |
| TFEB | protects_against | gene | 0.70 |
| SYN1 | activates | gene | 0.70 |
| STAT3 | interacts_with | gene | 0.70 |
| SNAP25 | biomarker_for | gene | 0.70 |
| UBIQUITIN | inhibits | protein | 0.70 |
| hippocampus | expressed_in | brain_region | 0.70 |
| AKT | activates | gene | 0.70 |
| Inflammation | activates | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Depression | activates | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| glutamate signaling | participates_in | pathway | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Retinal Degeneration | activates | disease | 0.65 |
| Neuroinflammation | therapeutic_target | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Neurodegeneration | therapeutic_target | disease | 0.65 |
| Dementia | expressed_in | disease | 0.65 |
| Anxiety | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Tauopathy | therapeutic_target | disease | 0.65 |
| Stroke | therapeutic_target | disease | 0.65 |
| LONG-TERM POTENTIATION | inhibits | phenotype | 0.65 |
| Aging | inhibits | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Autoimmune | regulates | disease | 0.65 |
| Ischemia | therapeutic_target | disease | 0.65 |
| Anxiety | interacts_with | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| unfolded protein response | participates_in | pathway | 0.65 |
| Traumatic Brain Injury | activates | disease | 0.65 |
| Multiple Sclerosis | activates | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Depression | inhibits | disease | 0.65 |
| Obesity | activates | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NPFF | upregulates | protein | 0.90 |
| SYN3 | interacts_with | drug | 0.90 |
| CN2097 | interacts_with | drug | 0.90 |
| CCL5 | upregulates | protein | 0.88 |
| Copper | inhibits | compound | 0.85 |
| Levomilnacipran | upregulates | drug | 0.85 |
| Surgery | downregulates | process | 0.85 |
| Copper | downregulates | compound | 0.80 |
| NLGN1 | interacts_with | gene | 0.80 |
| SLC17A7 | functionally_coupled_to | gene | 0.80 |
| CREB | expressed_in | gene | 0.70 |
| BDNF | expressed_in | gene | 0.70 |
| CHAT | activates | gene | 0.70 |
| BDNF | markers | gene | 0.70 |
| FRONTOTEMPORAL DEMENTIA | interacts_with | disease | 0.70 |
| APP | expressed_in | gene | 0.70 |
| GAP43 | expressed_in | gene | 0.70 |
| BDNF | disrupts | gene | 0.70 |
| MICROGLIA | protects_against | cell_type | 0.70 |
| PINK1 | activates | gene | 0.70 |
| LRRK2 | interacts_with | gene | 0.70 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | disease | 0.70 |
| GRIA1 | associated_with | gene | 0.70 |
| LRRK2 | expresses | gene | 0.70 |
| IBA1 | activates | gene | 0.70 |
| BDNF | associated_with | gene | 0.70 |
| NEURODEGENERATION | treats | gene | 0.70 |
| APP | interacts_with | gene | 0.70 |
| APP | regulates | gene | 0.70 |
| SYNAPTOPHYSIN | activates | gene | 0.70 |
| BDNF | enhances | gene | 0.70 |
| CREB | activates | gene | 0.70 |
| WNT SIGNALING | inhibits | pathway | 0.70 |
| MTOR | activates | gene | 0.65 |
| HIPPOCAMPUS | associated_with | brain_region | 0.65 |
| NEURONS | treats | cell_type | 0.65 |
| CA1 | regulates | brain_region | 0.65 |
| MICROGLIA | associated_with | cell_type | 0.64 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.64 |
| AND | activates | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| NEURODEGENERATION | therapeutic_target | gene | 0.60 |
| EPILEPSY | activates | gene | 0.60 |
| SYNAPSE | therapeutic_target | gene | 0.60 |
| GLUT4 | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| GENES | protects_against | gene | 0.60 |
| AMYLOID-BETA | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 | 0.861 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Oxygen Pressure-Dependent BDNF Cascade: DHHC2/PSD95 Stabiliz | 0.580 | neurodegeneration | View |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814
neuroscience | 2026-04-03 | 67 hypotheses Top: 1.000
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.784
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.795
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Synaptic plasticity and protein expression analysis in mPFC | exploratory | insomnia-anxiety comorbidity | 0.850 | 0.00 | mPFC brain slices from PCPA-tr | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.90 · 2026-04-12
closed · Rounds: 4 · Score: 0.89 · 2026-04-06
closed · Rounds: 4 · Score: 0.83 · 2026-04-06
closed · Rounds: 3 · Score: 0.95 · 2026-04-04
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
Hypotheses and analyses mentioning PSD95 in their description or question text
No additional research found