| Gene Symbol | MAP2K7 |
| Aliases | MAP2K7 (MEK7) |
| Function | is a central mediator of cellular stress responses and plays critical roles in neuronal survival, synaptic plasticity, neuroinflammation, and neurodegeneration. |
| Subcellular Localization | and interaction partners |
| Amino Acids | 447 aa |
| Pathways | pathway:[@kuan2002], MAPK |
| Ensembl ID | ENSG00000100030 |
| GeneCards | MAP2K7 |
| Human Protein Atlas | MAP2K7 |
| Cellular stress | Oxidative stress, DNA damage, ER stress |
| Inflammatory cytokines | TNF-α, IL-1β, Fas ligand |
| Excitotoxicity | Glutamate receptor overactivation |
| Neurotoxic proteins | Aβ, α-synuclein, mutant huntingtin |
| Growth factor withdrawal | Trophic factor deprivation |
| JNK1 (MAPK8) | Ubiquitously expressed, JNK1a and JNK1b splice variants |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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