protein 1,612 words KG: MAP2
Contents

MAP2 Protein — Microtubule-Associated Protein 2

🔬 Protein Info
Gene SymbolMAP2
Full NameMAP2 — Microtubule-Associated 2
AliasesMicrotubule-Associated Protein 2
Protein TypeProtein
Functionis a neuronal cytoskeletal protein that plays essential roles in dendritic arborization, synaptic stability, and microtubule stabilization in neurons[@dehmelt2003].
Primary Expressionneuronal cell bodies and dendrites, where it serves as a critical organizer of the dendritic cytoskeleton[@binder1985]
Molecular Weight280 kDa
PathwaysApoptosis, Autophagy, Dna Methylation, Epigenetic, Glycolysis
UniProt IDSearch UniProt
GeneCardsMAP2
Human Protein AtlasMAP2
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/Compoundsrapamycin
InteractionsACTB, Actin, AKT, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections388 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (15)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Axonal RNA Transport Reconstitution
Score: 0.70
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Score: 0.63
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57

Related Analyses (14)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (8)

TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40
s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40

See Also (6)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ACTB Gene
gene · KG edge: activates
ATG7 Gene
gene · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: regulates

Knowledge Graph (12 edges)

MAP2 interacts_with MAP1B
MAP2 interacts_with MAP6
ACTB activates MAP2
LAMP1 associated_with MAP2
MTOR associated_with MAP2
LC3 associated_with MAP2
TUBB3 associated_with MAP2
ATG7 activates MAP2
JUN activates MAP2
SQSTM1 associated_with MAP2

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