| Gene Symbol | MAP2K2 |
| Aliases | MAP2K2PROTEIN |
| Chromosome | 19p13.3 |
| Protein Type | Gene |
| Function | encodes a dual-specificity serine/threonine kinase that plays a central role in the RAS-RAF-MEK-ERK (MAPK) signaling cascade. |
| Subcellular Localization | </strong> Cytoplasm, plasma membrane</div> |
| Molecular Weight | 44 kDa |
| Amino Acids | 400 aa |
| Exons | 11 |
| Pathways | MAPK, MAPK pathway |
| GeneCards | MAP2K2 |
| Human Protein Atlas | MAP2K2 |
| N-terminal Regulatory Domain | Contains docking motifs for ERK substrate recognition |
| Kinase Domain | Dual-specificity kinase that phosphorylates ERK1/2 on threonine and tyrosine |
| C-terminal Tail | Regulatory sequences including activation loop phosphorylation sites |
| Associated Diseases | neurodegeneration |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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