Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C1QB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
C1QB is a gene implicated in neurodegeneration research. Key relationships include: regulates, interacts with, activates. Associated with Als, Amyotrophic Lateral Sclerosis, Carcinoma. Connected to 33 entities in the SciDEX knowledge graph.
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| Gene Symbol | C1QB |
| Full Name | Complement Component 1Q Subunit Beta |
| Chromosome | 1p36.12. |
| Protein Type | Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the liver as the main source of circulating C1q |
| Amino Acids | 245 aa |
| Exons | 2 |
| Pathways | Complement, Immune Response |
| NCBI Gene ID | 713 |
| GeneCards | C1QB |
| Human Protein Atlas | C1QB |
| Associated Diseases | Aging, Als, Alzheimer, Atherosclerosis, Cancer |
| Interactions | AIF1, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS |
| KG Connections | 251 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
C1QB["C1QB"]
Als{"Als"}
C1QB -->|"activates"| Als
Ms{"Ms"}
C1QB -->|"activates"| Ms
Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
C1QB -->|"activates"| Amyotrophic_Lateral_Sclerosis
Heart_Failure{"Heart Failure"}
C1QB -->|"regulates"| Heart_Failure
C1QB -->|"regulates"| Als
Hepatitis{"Hepatitis"}
C1QB -->|"regulates"| Hepatitis
Cardiac{"Cardiac"}
C1QB -->|"regulates"| Cardiac
MET["MET"]
C1QB -->|"interacts with"| MET
C1Q["C1Q"]
C1QB -->|"interacts with"| C1Q
Complement(["Complement"])
C1QB -->|"interacts with"| Complement
Immune_Response(["Immune Response"])
C1QB -->|"interacts with"| Immune_Response
ASTROCYTES["ASTROCYTES"]
C1QB -->|"activates"| ASTROCYTES
COMPLEMENT["COMPLEMENT"]
COMPLEMENT -->|"interacts with"| C1QB
CTSH["CTSH"]
CTSH -->|"interacts with"| C1QB
CCR1["CCR1"]
CCR1 -->|"regulates"| C1QB
MRC1["MRC1"]
MRC1 -->|"regulates"| C1QB
style C1QB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Immune Cell Infiltration | associated_with | process | 0.80 |
| complement cascade | participates_in | pathway | 0.70 |
| ALS | regulates | disease | 0.65 |
| Tumor | biomarker_for | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Anxiety | regulates | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Atherosclerosis | associated_with | disease | 0.65 |
| Inflammation | contributes_to | disease | 0.65 |
| Aging | regulates | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Neurodegeneration | interacts_with | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | activates | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Aging | expressed_in | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Hepatitis | regulates | disease | 0.65 |
| Cardiac | regulates | disease | 0.65 |
| Heart Failure | regulates | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Neurodegeneration | therapeutic_target | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Senescence | associated_with | disease | 0.65 |
| CD163 | regulates | gene | 0.60 |
| CXCL10 | regulates | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| Microglia | regulates | cell_type | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| COMPLEMENT | therapeutic_target | gene | 0.60 |
| APP/PS1 | therapeutic_target | gene | 0.60 |
| COMPLEMENT | regulates | gene | 0.60 |
| Complement System | regulates | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| CD38 | regulates | gene | 0.60 |
| P2RY12 | biomarker_for | gene | 0.60 |
| SNAP25 | biomarker_for | gene | 0.60 |
| SYP | biomarker_for | gene | 0.60 |
| ASTROCYTES | activates | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | activates | gene | 0.60 |
| HSPB1 | interacts_with | gene | 0.60 |
| ALS | activates | gene | 0.60 |
| NLRP3 | biomarker_for | gene | 0.60 |
| C1R | biomarker_for | gene | 0.60 |
| C1S | biomarker_for | gene | 0.60 |
| C3 | biomarker_for | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CYBB | associated_with | gene | 0.60 |
| COMPLEMENT | therapeutic_target | gene | 0.60 |
| C1QC | regulates | gene | 0.60 |
| C1R | regulates | gene | 0.60 |
| CD47 | regulates | gene | 0.60 |
| C1S | regulates | gene | 0.60 |
| MERTK | regulates | gene | 0.60 |
| C1QA | associated_with | gene | 0.60 |
| C1QA | regulates | gene | 0.60 |
| ITGAM | regulates | gene | 0.60 |
| SIRPA | regulates | gene | 0.60 |
| C1QA | biomarker_for | gene | 0.60 |
| C1QC | biomarker_for | gene | 0.60 |
| CYBB | biomarker_for | gene | 0.60 |
| ITGAM | biomarker_for | gene | 0.60 |
| AIF1 | biomarker_for | gene | 0.60 |
| CD68 | biomarker_for | gene | 0.60 |
| C4B | biomarker_for | gene | 0.60 |
| TMEM119 | biomarker_for | gene | 0.60 |
| TREM2 | biomarker_for | gene | 0.60 |
| APP | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| APP/PS1 | therapeutic_target | gene | 0.60 |
| MICROGLIA | regulates | gene | 0.60 |
| INFLAMMATION | contributes_to | gene | 0.60 |
| PHAGOCYTOSIS | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| HUB GENES | associated_with | gene | 0.60 |
| CSF1R | associated_with | gene | 0.60 |
| COMPLEMENT | interacts_with | gene | 0.60 |
| NEURODEGENERATION | interacts_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| ALZHEIMER | interacts_with | gene | 0.60 |
| CCR1 | regulates | gene | 0.60 |
| MRC1 | regulates | gene | 0.60 |
| CD68 | regulates | gene | 0.60 |
| INOS | biomarker_for | gene | 0.60 |
| MICROGLIA | biomarker_for | gene | 0.60 |
| COMPLEMENT | biomarker_for | gene | 0.60 |
| C1QA | expressed_in | gene | 0.60 |
| C1QA | interacts_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| COMPLEMENT | regulates | gene | 0.60 |
| SYNAPTIC PRUNING | associated_with | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| COMPLEMENT GENES | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I | 0.747 | neurodegeneration | Are interneuron oscillation deficits com |
Scientific analyses that reference this entity
molecular biology | 2026-04-17 | 10 hypotheses Top: 0.455
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.747
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Single-cell RNA sequencing analysis of human atherosclerotic plaques | exploratory | Atherosclerosis | 0.900 | 0.00 | Human atherosclerotic plaque s | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808] | Sanfilippo C, Castrogiovanni P, Imbesi R | Geroscience | 2026 | 0 |
| Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808] | Sanfilippo C, Castrogiovanni P, Imbesi R | GeroScience | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 1.00 · 2026-04-19
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.76 · 2026-04-16
Hypotheses and analyses mentioning C1QB in their description or question text
No additional research found