gene

C1QB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C1QB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

251Connections
1Hypotheses
2Analyses
50Outgoing
50Incoming
1Experiments
3Debates

Summary

C1QB is a gene implicated in neurodegeneration research. Key relationships include: regulates, interacts with, activates. Associated with Als, Amyotrophic Lateral Sclerosis, Carcinoma. Connected to 33 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolC1QB
Full NameComplement Component 1Q Subunit Beta
Chromosome1p36.12.
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe liver as the main source of circulating C1q
Amino Acids245 aa
Exons2
PathwaysComplement, Immune Response
NCBI Gene ID713
GeneCardsC1QB
Human Protein AtlasC1QB
Associated DiseasesAging, Als, Alzheimer, Atherosclerosis, Cancer
InteractionsAIF1, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS
KG Connections251 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

C1QB — Complement Component 1Q Beta

gene · 683 words

C1QB Protein — Complement Component 1 Q

protein · 1611 words

Pathway Diagram

graph TD
    C1QB["C1QB"]
    Als{"Als"}
    C1QB -->|"activates"| Als
    Ms{"Ms"}
    C1QB -->|"activates"| Ms
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    C1QB -->|"activates"| Amyotrophic_Lateral_Sclerosis
    Heart_Failure{"Heart Failure"}
    C1QB -->|"regulates"| Heart_Failure
    C1QB -->|"regulates"| Als
    Hepatitis{"Hepatitis"}
    C1QB -->|"regulates"| Hepatitis
    Cardiac{"Cardiac"}
    C1QB -->|"regulates"| Cardiac
    MET["MET"]
    C1QB -->|"interacts with"| MET
    C1Q["C1Q"]
    C1QB -->|"interacts with"| C1Q
    Complement(["Complement"])
    C1QB -->|"interacts with"| Complement
    Immune_Response(["Immune Response"])
    C1QB -->|"interacts with"| Immune_Response
    ASTROCYTES["ASTROCYTES"]
    C1QB -->|"activates"| ASTROCYTES
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"interacts with"| C1QB
    CTSH["CTSH"]
    CTSH -->|"interacts with"| C1QB
    CCR1["CCR1"]
    CCR1 -->|"regulates"| C1QB
    MRC1["MRC1"]
    MRC1 -->|"regulates"| C1QB
    style C1QB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (170)

TargetRelationTypeStr
Immune Cell Infiltrationassociated_withprocess0.80
complement cascadeparticipates_inpathway0.70
ALSregulatesdisease0.65
Tumorbiomarker_fordisease0.65
ALSassociated_withdisease0.65

Incoming (81)

SourceRelationTypeStr
CYBBassociated_withgene0.60
COMPLEMENTtherapeutic_targetgene0.60
C1QCregulatesgene0.60
C1Rregulatesgene0.60
CD47regulatesgene0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I 0.747 neurodegeneration Are interneuron oscillation deficits com

Mentioning Analyses (2)

Scientific analyses that reference this entity

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

molecular biology | 2026-04-17 | 10 hypotheses Top: 0.455

Are interneuron oscillation deficits compensatory responses or primary pathologi

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.747

Experiments (1)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Single-cell RNA sequencing analysis of human atherosclerotic plaques exploratory Atherosclerosis 0.900 0.00 Human atherosclerotic plaque s proposed N/A

Related Papers (2)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808] Sanfilippo C, Castrogiovanni P, Imbesi R Geroscience 2026 0
Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808] Sanfilippo C, Castrogiovanni P, Imbesi R GeroScience 2026 0

Debates (3)

Multi-agent debates referencing this entity

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 1.00 · 2026-04-19

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

The debate raised whether SST/PV interneuron dysfunction represents adaptive com

closed · Rounds: 4 · Score: 0.76 · 2026-04-16

Related Research

Hypotheses and analyses mentioning C1QB in their description or question text

No additional research found