gene

MAP6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

192Connections
8Hypotheses
1Analyses
50Outgoing
50Incoming
10Experiments
1Debates

Summary

MAP6 is a gene implicated in neurodegeneration research. Key relationships include: regulates, interacts with, implicated in. Associated with AD, ALI, ALS. Connected to 60 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolMAP6
Chromosome11q13.2
Protein TypeStructural Protein
Target ClassStructural Protein
FunctionUnlike other MAPs that promote microtubule assembly, MAP6 stabilizes microtubules by preventing depolymerization and protecting them from disassembly under stress conditions[@takemura2018].
Mechanism of ActionDrugs targeting MAP6 would stabilize microtubules through direct binding or modulation of MAP6's stabilizing activity, thereby promoting neuronal cytoskeletal integrity and synaptic function. This stabilization could enhance axonal transport, prevent neuronal degeneration, and support cognitive and synaptic plasticity in neurodegenerative conditions.
Primary Expressionneurons throughout development and in adulthood
Subcellular Localization4. **Proteolytic cleavage**: Specific cleavage generates functional fragments
DruggabilityUndruggable (0.21)
Clinical StagePhase II
Molecular Weight85 kDa
Amino Acids789 aa
Exons14
PathwaysTau-Independent Microtubule Stabilization via MAP6
UniProt IDQ96JE9
GeneCardsMAP6
Human Protein AtlasMAP6
Associated DiseasesAD, ALI, Als, AMI, neurodegeneration
Known Drugs/CompoundsPaclitaxel (Taxol), Ixabepilone (Ixempra), MAP6-derived peptide stabilizers, Microtubule-associated protein kinase inhibitors
InteractionsC1Q, CDK5, CRMP1, HDAC, MAP1A, MAP1B
SciDEX TargetView Target Profile (1 clinical trials)
SciDEX HypothesesTau/MAP6 antagonism in neurodegeneration progressi
Activity-dependent MAP6 scaffolding at synapses
Domain boundary cross-talk hypothesis (+2 more)
KG Connections192 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: MAP6 — AlphaFold Q96JE9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MAP6 Gene

gene · 2761 words

MAP6 Protein — Microtubule-Associated Protein 6

protein · 1089 words

Pathway Diagram

graph TD
    MAP6["MAP6"]
    Microtubule_Stable_Domain(["Microtubule Stable Domain"])
    MAP6 -->|"modulates"| Microtubule_Stable_Domain
    Microtubule_Stability(["Microtubule Stability"])
    MAP6 -->|"activates"| Microtubule_Stability
    Microtubules["Microtubules"]
    MAP6 -->|"interacts with"| Microtubules
    Neuronal_Development(["Neuronal Development"])
    MAP6 -->|"regulates"| Neuronal_Development
    Axon_Microtubule_Organization(["Axon Microtubule Organization"])
    MAP6 -->|"regulates"| Axon_Microtubule_Organization
    Growth_Cone_Turning(["Growth Cone Turning"])
    MAP6 -->|"modulates"| Growth_Cone_Turning
    Axonal_Branching(["Axonal Branching"])
    MAP6 -->|"regulates"| Axonal_Branching
    Neuronal_Migration(["Neuronal Migration"])
    MAP6 -->|"regulates"| Neuronal_Migration
    Tau_Independent_Microtubule_Stabilizatio["Tau-Independent Microtubule Stabilization via MAP6"]
    MAP6 -->|"regulates"| Tau_Independent_Microtubule_Stabilizatio
    Als{"Als"}
    MAP6 -->|"interacts with"| Als
    MAP6 -->|"associated with"| Als
    ALS{"ALS"}
    MAP6 -->|"interacts with"| ALS
    h_e12109e3["h-e12109e3"]
    h_e12109e3 -->|"therapeutic target"| MAP6
    h_e12109e3 -->|"targets"| MAP6
    Tau["Tau"]
    Tau -->|"associated with"| MAP6
    MAP2["MAP2"]
    MAP2 -->|"interacts with"| MAP6
    MAP1B["MAP1B"]
    MAP1B -->|"interacts with"| MAP6
    MAPT["MAPT"]
    MAPT -->|"associated with"| MAP6
    NEURON["NEURON"]
    NEURON -->|"stabilizes"| MAP6
    MICROTUBULES["MICROTUBULES"]
    MICROTUBULES -->|"regulates"| MAP6
    MICROTUBULES -->|"causes"| MAP6
    AND["AND"]
    AND -->|"regulates"| MAP6
    RELN["RELN"]
    RELN -->|"co discussed"| MAP6
    PPARGC1A["PPARGC1A"]
    PPARGC1A -->|"co discussed"| MAP6
    style MAP6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (135)

TargetRelationTypeStr
Microtubuleinteracts_withpathway0.95
Microtubule Stabilizationmediatesprocess0.95
Microtubule Stable Domainassociated_withprocess0.95
Microtubule Stabilityactivatesprocess0.95
MICROTUBULEbinds_toentity0.95

Incoming (57)

SourceRelationTypeStr
h-e12109e3targetshypothesis0.90
MAPTinhibitsgene0.90
TAUinteracts_withentity0.90
MAPTinteracts_withprotein0.85
Tauassociated_withprotein0.80

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Tau/MAP6 ratio as a master switch for microtubule dynamics p 0.750 neurodegeneration View
MAP6-CRMPS cooperative phosphorylation by GSK3β 0.700 neurodegeneration View
Tau/MAP6 antagonism in neurodegeneration progression 0.650 neurodegeneration View
Domain boundary cross-talk hypothesis 0.600 neurodegeneration View
Activity-dependent MAP6 scaffolding at synapses 0.600 neurodegeneration View
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme 0.567 neurodegeneration Selective vulnerability of entorhinal co
Developmental stage-specific dominance of tau vs MAP6 functi 0.550 neurodegeneration View
MAP6-mediated microtubule stabilization as therapeutic targe 0.500 neurodegeneration View

Mentioning Analyses (1)

Scientific analyses that reference this entity

Selective vulnerability of entorhinal cortex layer II neurons in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.696

Experiments (10)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
MAP6 depletion effects on neuronal development in primary cultures exploratory 0.900 0.00 primary rodent neuronal cultur proposed N/A
MAP6 depletion effects on neuronal development in primary cultures exploratory 0.900 0.00 primary rodent neuronal cultur proposed N/A
In vivo neuronal migration assay with MAP6 depletion validation 0.850 0.00 rodent in vivo model proposed N/A
4R-Tau Targeting Therapies for PSP and CBS clinical Alzheimer's Disease 0.400 0.50 human proposed $6,550,000
Anti-Tau Immunotherapy Dosing Optimization clinical Alzheimer's Disease 0.400 0.50 human proposed $5,460,000
Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy in 4R-Tau validation Neurodegeneration 0.400 0.50 cell_line proposed $170,000
Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Trials Have N clinical ALS 0.400 0.50 human proposed $7,500,000
Axonal Transport Dysfunction Validation in Parkinson's Disease clinical Parkinson's Disease 0.400 0.50 human proposed $6,550,000
Blood Biomarker vs Tau PET for Treatment Monitoring clinical ALS 0.400 0.50 human proposed $5,460,000
CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omics Study validation Neurodegeneration 0.400 0.50 cell_line proposed $160,000

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Tau and MAP6 establish labile and stable domains on microtubules. [PMID:40040809] Kirimtay K, Huang W, Sun X, Qiang L, Wan iScience 2025 1
Antagonistic roles of tau and MAP6 in regulating neuronal development. [PMID:39257379] Sun X, Yu W, Baas PW, Toyooka K, Qiang L J Cell Sci 2024 1
Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Storie [PMID:34025352] Cuveillier C, Boulan B, Ravanello C, Den Front Mol Neurosci 2021 1
Tau: It's Not What You Think. [PMID:30929793] Baas PW, Qiang L Trends Cell Biol 2019 1
Stability properties of neuronal microtubules. [PMID:26887570] Baas PW, Rao AN, Matamoros AJ, Leo L Cytoskeleton (Hoboken) 2016 1
Targeting CXCL16-expressing macrophages with a biomimetic nanocarrier system att [PMID:41707770] Yang Q, Xu Y, Zhan Y, Li J, Peng R, Yu B Journal of controlled release 2026 0
The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory. [PMID:41825505] Jia Y, Lei J, Jiang Y, Xue L, Chen T, Wa Neuropharmacology 2026 0
BioID2-Based Tau Interactome Reveals Novel and Known Protein Interactions Associ [PMID:40910579] Atwa A, Alhadidy MM, Lamp J, Combs B, Ka Journal of proteome research 2025 0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] ["Sanadgol N", "Abedi M", "Hashemzaei M" Journal of nanobiotechnology 2025 0
ReMAPping the microtubule landscape: How phosphorylation dictates the activities [PMID:28980356] Ramkumar A, Jong BY, Ori-McKenney KM Developmental dynamics : an of 2018 0
Inferring patterns of folktale diffusion using genomic data. [PMID:28784786] ["Bortolini E", "Pagani L", "Crema E", " Proceedings of the National Ac 2017 0
Purification and Characterization of Progenitor and Mature Human Astrocytes Reve [PMID:26687838] ["Zhang Y", "Sloan S", "Clarke L", "Cane Neuron 2016 0
Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severin [PMID:24065130] ["Zempel H", "Luedtke J", "Kumar Y", "Bi The EMBO journal 2013 0
Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). [PMID:21902667] Gozes I Current pharmaceutical design 2011 0
Decreased neuroautonomic complexity in men during an acute major depressive epis [PMID:22832529] ["Leistedt S", "Linkowski P", "Lanquart Translational psychiatry 2011 0
Bidirectional activity-dependent plasticity at corticostriatal synapses. [PMID:16339023] ["Fino E", "Glowinski J", "Venance L"] The Journal of neuroscience : 2005 0
STOP proteins. [PMID:14567673] Bosc C, Andrieux A, Job D Biochemistry 2003 0
Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hy [PMID:12070343] ["Zhao R", "Masayasu H", "Holmgren A"] Proceedings of the National Ac 2002 0
STOP proteins. [PMID:15218867] Bosc C, Oenarier E, Andrieux A, Job D Cell structure and function 1999 0

Debates (1)

Multi-agent debates referencing this entity

Why do entorhinal cortex layer II stellate neurons die first in AD? Their unique

closed · Rounds: 6 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning MAP6 in their description or question text

Tau-Independent Microtubule Stabilization via MAP6 Enhancement

Score: 0.567 · neurodegeneration · 2026-04-02

## Mechanistic Overview Tau-Independent Microtubule Stabilization via MAP6 Enhancement starts from the claim that modula

Developmental stage-specific dominance of tau vs MAP6 function

Score: 0.550 · neurodegeneration · 2026-04-25

During early development, tau predominates to maximize plasticity and rapid axon extension; as maturation proceeds, MAP6

MAP6-mediated microtubule stabilization as therapeutic target

Score: 0.500 · neurodegeneration · 2026-04-25

Aberrant MAP6 function may contribute to tau-independent cytoskeletal defects in neurodegeneration, and stabilizing MAP6