concept

OCT4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OCT4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

264Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

5Experiments

1Debates

Summary

OCT4 is a concept in neurodegeneration research. Key relationships include: therapeutic target, activates, regulates. Associated with Aging, Als, Alzheimer. Connected to 144 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	OCT4
Key Genes/Proteins	AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AND
Related Diseases	aging, Aging, Als, Alzheimer
Related Pathways	Autophagy
Linked Hypotheses	1 hypotheses

Pathway Diagram

graph TD
    OCT4["OCT4"]
    OCT4 -->|"activates"| Pluripotency["Pluripotency"]
    OCT4 -->|"involved_in"| Self_Renewal["Self-Renewal"]
    OCT4 -->|"activates"| cellular_reprogramming["cellular_reprogramming"]
    OCT4 -.biomarker for.-> Aging["Aging"]
    OCT4 -->|"activates"| Senescence["Senescence"]
    OCT4 -->|"activates"| Cardiovascular["Cardiovascular"]
    OCT4 -->|"activates"| Tumor["Tumor"]
    OCT4 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    OCT4 -->|"regulates"| Alzheimer["Alzheimer"]
    OCT4 -->|"expressed in"| Carcinoma["Carcinoma"]
    Melatonin["Melatonin"] -->|"upregulates"| OCT4
    h_baba5269["h-baba5269"] -->|"targets"| OCT4
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"activates"| OCT4
    POU5F1["POU5F1"] -->|"activates"| OCT4
    AND["AND"] -->|"activates"| OCT4
    DNA["DNA"] -->|"activates"| OCT4
    KLF4["KLF4"] -->|"activates"| OCT4
    MYC["MYC"] -.biomarker for.-> OCT4
    GENES["GENES"] -->|"activates"| OCT4
    AGING["AGING"] -.biomarker for.-> OCT4

Outgoing (181)

Target	Relation	Type	Str
h-05b40151e8	targeted_by	hypothesis	1.00
h-99dd982b52	targeted_by	hypothesis	1.00
iPSC Reprogramming	involved_in	process	0.95
Pluripotency	activates	phenotype	0.90
Pluripotency	associated_with	phenotype	0.90
Self-Renewal	involved_in	process	0.90
Pluripotency	promotes	process	0.90
Cellular Senescence	associated_with	process	0.85
Alzheimer's Disease	associated_with	disease	0.80
cellular_reprogramming	activates	pathway	0.80
SOX2	regulates	gene	0.80
Aging	expressed_in	disease	0.75
Cancer	inhibits	disease	0.75
Als	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Tumor	inhibits	disease	0.75
Metastasis	inhibits	pathway	0.70
CANCER	therapeutic_target	gene	0.70
Mtor	therapeutic_target	pathway	0.70
Stem Cell	inhibits	pathway	0.70
CANCER	inhibits	gene	0.70
AKT	therapeutic_target	gene	0.70
MTOR	therapeutic_target	gene	0.70
KLF4	regulates	gene	0.70
Breast Cancer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Senescence	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Senescence	activates	disease	0.65
Aging	biomarker_for	disease	0.65
Neurodegeneration	activates	disease	0.65
Senescence	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Tumor	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Aging	regulates	disease	0.65
Ms	activates	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Wnt	therapeutic_target	pathway	0.60
Metastasis	therapeutic_target	pathway	0.60
Notch	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
Multidrug Resistance	therapeutic_target	pathway	0.60
FERROPTOSIS	associated_with	gene	0.60
LC3B	associated_with	gene	0.60

Incoming (83)

Source	Relation	Type	Str
h-05b40151e8	targets	hypothesis	1.00
h-99dd982b52	targets	hypothesis	1.00
SOX2	interacts_with	gene	0.90
h-baba5269	targets_gene	hypothesis	0.90
h-baba5269	targets	hypothesis	0.80
Melatonin	upregulates	drug	0.70
AGING	expressed_in	gene	0.70
CD44	inhibits	gene	0.60
BNIP3	inhibits	gene	0.60
AGING	biomarker_for	gene	0.60
PINK1	inhibits	gene	0.60
AGING	regulates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
EXOSOMES	therapeutic_target	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
GENES	activates	gene	0.60
BAX	inhibits	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MIRNAS	regulates	gene	0.60
KLF4	expressed_in	gene	0.60
PPAR	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
BECLIN1	associated_with	gene	0.60
MITOPHAGY	inhibits	gene	0.60
AND	activates	gene	0.60
SOX2	activates	gene	0.60
SOX2	regulates	gene	0.60
SOX2	encodes	gene	0.60
EGFR	associated_with	gene	0.60
POU5F1	activates	gene	0.60
KLF4	activates	gene	0.60
CLOCK	associated_with	gene	0.60
PTEN	therapeutic_target	gene	0.60
NANOG	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
ERK	causes	gene	0.60
NANOG	encodes	gene	0.60
DNA	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
C-MYC	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
NANOG	regulates	gene	0.60
DAX1	regulates	gene	0.60
AND	regulates	gene	0.60
MYC	biomarker_for	gene	0.60
KLF4	biomarker_for	gene	0.60
DNMT3A	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai	0.672	neurodegeneration	Epigenetic reprogramming in aging neuron
Transient OCT4/SOX2/KLF4/c-MYC Expression Reverses Epigeneti	0.540	neurodegeneration	epigenetic reprogramming aging neurons

Mentioning Analyses (1)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.914

Experiments (5)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Proposed experiment from debate on Microglia activate astrocytes via I	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
AAV-LRRK2 IND-Enabling Study Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
CRISPR Gene Correction Approaches for CBS/PSP	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
AAV-LRRK2 Gene Therapy IND-Enabling Study Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develo	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Engineered LINC MIR503HG-loaded extracellular vesicles maintain stemness and plu [PMID:41551196]	Zhu J, Zhu X, Feng W, Jin Y, Ge X et al.	Bioact Mater	2026
Development of a practical GMP-compliant manufacturing process for T cell-derive [PMID:41691922]	Hulspas R, Sasso C, Cunningham A, Cancel	Cytotherapy	2026
Establishment of a human induced pluripotent stem cell line (BTHBIOi005-A) from [PMID:41713384]	Liu ZY, Zhang H, Zhang XH, Shen RJ, Jin	Stem Cell Res	2026
Gene Therapy-Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Re [PMID:38381405]	Macip CC, Hasan R, Hoznek V, Kim J, Lu Y	Cellular reprogramming	2024
Targeted partial reprogramming of age-associated cell states improves markers of [PMID:39259812]	Sahu SK, Reddy P, Lu J, Shao Y, Wang C,	Science translational medicine	2024
Development of a clinical polygenic risk score assay and reporting workflow. [PMID:35437332]	["Hao L", "Kraft P", "Berriz G", "Hynes	Nature medicine	2022
Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mi [PMID:33268894]	["Karigo T", "Kennedy A", "Yang B", "Liu	Nature	2021
Predicting ambient PM [PMID:32747729]	["Enebish T", "Chau K", "Jadamba B", "Fr	Journal of exposure science &	2021
Correction: MicroRNA signatures of TRAIL resistance in human non-small cell lung [PMID:33398039]	Garofalo M; Quintavalle C; Di Leva G; Za	Oncogene	2021
Mechanisms of OCT4-SOX2 motif readout on nucleosomes. [PMID:32327602]	Michael AK, Grand RS, Isbel L, Cavadini	Science (New York, N.Y.)	2020
The Use of Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish [PMID:32664640]	Biava PM	International journal of molec	2020
Tumour lineage shapes BRCA-mediated phenotypes. [PMID:31292550]	["Jonsson P", "Bandlamudi C", "Cheng M",	Nature	2019
Cooperative Binding of Transcription Factors Orchestrates Reprogramming. [PMID:28111071]	Chronis C, Fiziev P, Papp B, Butz S, Bon	Cell	2017
Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice. [PMID:28877458]	["Newman J", "Covarrubias A", "Zhao M",	Cell metabolism	2017
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. [PMID:27984723]	["Ocampo A", "Reddy P", "Martinez-Redond	Cell	2016
Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman pr [PMID:25297091]	["Forny-Germano L", "Lyra e Silva N", "B	The Journal of neuroscience :	2014
Structure and interactions of the human programmed cell death 1 receptor. [PMID:23417675]	["Cheng X", "Veverka V", "Radhakrishnan	The Journal of biological chem	2013
Location and cellular stages of natural killer cell development. [PMID:24055329]	["Yu J", "Freud A", "Caligiuri M"]	Trends in immunology	2013
A molecular roadmap of reprogramming somatic cells into iPS cells. [PMID:23260147]	["Polo J", "Anderssen E", "Walsh R", "Sc	Cell	2012
Direct conversion of fibroblasts into stably expandable neural stem cells. [PMID:22445518]	["Thier M", "W\u00f6rsd\u00f6rfer P", "L	Cell stem cell	2012

Debates (1)

Multi-agent debates referencing this entity

Epigenetic reprogramming in aging neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-10