protein 1,263 words KG: MAP2PROTEIN
Contents

MAP2 Protein

🔬 Protein Info
Gene SymbolMAP2
Full NameMAP2 — Microtubule-Associated 2
AliasesMicrotubule-Associated Protein 2
Protein TypeProtein
Functionis a neuronal cytoskeletal protein that plays essential roles in dendritic arborization, synaptic stability, and microtubule stabilization in neurons[@dehmelt2003].
Primary Expressionneuronal cell bodies and dendrites, where it serves as a critical organizer of the dendritic cytoskeleton[@binder1985]
Molecular Weight280 kDa
PathwaysApoptosis, Autophagy, Dna Methylation, Epigenetic, Glycolysis
UniProt IDSearch UniProt
GeneCardsMAP2
Human Protein AtlasMAP2
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/Compoundsrapamycin
InteractionsACTB, Actin, AKT, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections388 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (6)

Axonal RNA Transport Reconstitution
Score: 0.70
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57

Related Analyses (8)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (8)

TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40
s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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