gene

C1R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

93Connections

1Hypotheses

0Analyses

50Outgoing

23Incoming

0Experiments

0Debates

Summary

c1r

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	C1R
Full Name	Complement Component 1, R Subcomponent
Chromosome	12p13.31
Protein Type	Protease
Function	is a critical component of the innate immune system, providing defense against pathogens and contributing to tissue homeostasis.
Primary Expression	the brain, where they participate in synaptic remodeling, neuroinflammation, and neurodegenerative processes
Pathways	Complement
UniProt ID	P09871
NCBI Gene ID	715
Ensembl ID	ENSG00000159403
OMIM	216950
GeneCards	C1R
Human Protein Atlas	C1R
Zymogen state	Catalytic domain blocks active site
Activation cleavage	Generates active protease
Associated Diseases	Aging, Alzheimer, Senescence
Interactions	BIN1, C1S, CD47, CLN5, CR1, GENES
KG Connections	93 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: C1R — AlphaFold P09871 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

C1R — Complement Component 1, R Subcomponent

gene · 2732 words

→

Pathway Diagram

graph TD
    C1R["C1R"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    Aging["Aging"]
    Senescence["Senescence"]
    SIRPA["SIRPA"]
    C1QC["C1QC"]
    C1S["C1S"]
    C1QA["C1QA"]
    AGING["AGING"]
    CD47["CD47"]
    Microglia["Microglia"]
    C1QB["C1QB"]
    ALZHEIMER["ALZHEIMER"]
    COMPLEMENT["COMPLEMENT"]
    GENES["GENES"]
    ITGAM["ITGAM"]
    MERTK["MERTK"]
    C1R -.-|"associated"| Alzheimer
    C1R -->|"regulates"| Als
    C1R -.-|"associated"| Aging
    C1R -.-|"associated"| Senescence
    C1R -->|"regulates"| SIRPA
    C1R -->|"regulates"| C1QC
    C1R -->|"regulates"| C1S
    C1R -->|"regulates"| C1QA
    C1R -.-|"associated"| AGING
    C1R -->|"regulates"| CD47
    C1R -->|"regulates"| Microglia
    C1QB -->|"regulates"| C1R
    ALZHEIMER -.-|"associated"| C1R
    COMPLEMENT -->|"regulates"| C1R
    C1R -.-|"discussed with"| C1S
    C1R -->|"activates"| CD47
    C1R -->|"activates"| GENES
    C1R -->|"regulates"| ITGAM
    C1R -->|"regulates"| MERTK
    C1R -->|"activates"| SIRPA
    style C1R fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (70)

Target	Relation	Type	Str
ALS	regulates	disease	0.65
Als	regulates	disease	0.65
Aging	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
complement cascade	participates_in	pathway	0.60
TMEM106B	associated_with	gene	0.60
TMEM106B	protects_against	gene	0.60
AGING	associated_with	gene	0.60
COMPLEMENT	regulates	gene	0.60
Microglia	regulates	cell_type	0.60
Complement System	regulates	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
C3	regulates	gene	0.60
CR1	interacts_with	gene	0.60
SIGLEC9	interacts_with	gene	0.60
SIRPA	interacts_with	gene	0.60
TPP1	interacts_with	gene	0.60
VEGFB	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
blood-brain barrier	participates_in	pathway	0.60
oligodendrocytes	expressed_in	cell_type	0.60
Alzheimer's disease	interacts_with	disease	0.60
Parkinson's disease	interacts_with	disease	0.60
ALS	interacts_with	disease	0.60
multiple sclerosis	interacts_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
C1QB	regulates	gene	0.60
C1S	interacts_with	gene	0.60
CLN5	interacts_with	gene	0.60
TREM2	biomarker_for	gene	0.60
C1QC	regulates	gene	0.60
C1S	regulates	gene	0.60
C1QA	regulates	gene	0.60
CD47	regulates	gene	0.60
SNAP25	biomarker_for	gene	0.60
SYP	biomarker_for	gene	0.60
TMEM119	biomarker_for	gene	0.60
SIRPA	regulates	gene	0.60
C1S	biomarker_for	gene	0.60
C3	biomarker_for	gene	0.60
CHI3L1	biomarker_for	gene	0.60
CSF1R	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
ITGAM	biomarker_for	gene	0.60
MAP2	biomarker_for	gene	0.60
MAPT	biomarker_for	gene	0.60
NLRP3	biomarker_for	gene	0.60
P2RY12	biomarker_for	gene	0.60
SYNAPTIC PRUNING	associated_with	gene	0.60

Incoming (23)

Source	Relation	Type	Str
AGING	associated_with	gene	0.60
GENES	regulates	gene	0.60
MERTK	regulates	gene	0.60
SIRPA	regulates	gene	0.60
C1S	regulates	gene	0.60
C1QB	regulates	gene	0.60
BIN1	associated_with	gene	0.60
BIN1	protects_against	gene	0.60
BIN1	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COMPLEMENT	regulates	gene	0.60
C1QA	regulates	gene	0.60
ITGAM	regulates	gene	0.60
CD47	regulates	gene	0.60
C1QA	biomarker_for	gene	0.60
C1QB	biomarker_for	gene	0.60
C1QC	biomarker_for	gene	0.60
C1QC	regulates	gene	0.60
AIF1	biomarker_for	gene	0.60
ALZHEIMER	regulates	gene	0.50
C1QB	co_discussed	gene	0.50
C1QC	co_discussed	protein	0.50
C1QA	co_discussed	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TNF-α–C1r/C1s Bridge Between NF-κB and Classical Complement	0.600	neuroinflammation	How does sevoflurane-induced NF-κB activ

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning C1R in their description or question text

No additional research found