gene 946 words KG: MAP2
Contents

MAP2 Gene

🧬 Gene Info
Gene SymbolMAP2
Full NameMicrotubule Associated Protein 2
AliasesMicrotubule-Associated Protein 2
Protein TypeProtein
Functionis a neuronal cytoskeletal protein that plays essential roles in dendritic arborization, synaptic stability, and microtubule stabilization in neurons[@dehmelt2003].
Primary Expressionneuronal cell bodies and dendrites, where it serves as a critical organizer of the dendritic cytoskeleton[@binder1985]
Subcellular Localizationdendrites. It plays critical roles in dendritic architecture, synaptic plasticity, microtubule stabilization, and intrac
Molecular Weight280 kDa
PathwaysApoptosis, Autophagy, Dna Methylation, Epigenetic, Glycolysis
UniProt IDSearch UniProt
GeneCardsMAP2
Human Protein AtlasMAP2
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/Compoundsrapamycin
InteractionsACTB, Actin, AKT, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections388 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (13)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Axonal RNA Transport Reconstitution
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (10)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (8)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Validation: Membrane-Nucleation in iPSC Neurons
validation · proposed · Score: 0.40
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40

See Also (8)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ACTB Gene
gene · KG edge: activates
ATG7 Gene
gene · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: regulates

Knowledge Graph (12 edges)

MAP2 interacts_with MAP1B
MAP2 interacts_with MAP6
ACTB activates MAP2
LAMP1 associated_with MAP2
MTOR associated_with MAP2
LC3 associated_with MAP2
TUBB3 associated_with MAP2
ATG7 activates MAP2
JUN activates MAP2
SQSTM1 associated_with MAP2

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