protein

IBA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IBA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1123Connections

5Hypotheses

1Analyses

50Outgoing

50Incoming

2Experiments

1Debates

Summary

IBA1 is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with AD, ALS, ALZHEIMER'S DISEASE. Connected to 250 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	IBA1
Full Name	Ionized Calcium-Binding Adapter Molecule 1
Function	is a protein encoded by the AIF1 gene that ### Microglial Marker
Molecular Weight	17.0 kDa
Amino Acids	147 aa
Pathways	Mapk
UniProt ID	[P55008](https://www.uniprot.org/uniprotkb/P55008)
GeneCards	IBA1
Human Protein Atlas	IBA1
Actin bundling	Crosslinks actin filaments into bundles
Membrane ruffling	Required for formation of membrane ruffles and lamellipodia
Motility	Essential for microglial migration and chemotaxis
Phagocytosis	Participates in phagocytic cup formation
Antigen presentation	Associated with MHC class II expression
Inflammatory signaling	Modulates cytokine production
Associated Diseases	AD, Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	rapamycin
Interactions	AB, ACTB, AD, ADAM10, AGING, AIF1
KG Connections	1120 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IBA1 Protein

protein · 785 words

→

Pathway Diagram

graph TD
    IBA1["IBA1"]
    IBA1 -->|"expressed in"| ALS["ALS"]
    IBA1 -->|"activates"| Alzheimer["Alzheimer"]
    IBA1 -->|"activates"| Aging["Aging"]
    IBA1 -->|"inhibits"| Inflammation["Inflammation"]
    IBA1 -->|"inhibits"| Tumor["Tumor"]
    IBA1 -->|"inhibits"| Parkinson["Parkinson"]
    IBA1 -->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| IBA1
    MICROGLIA["MICROGLIA"] -->|"expressed in"| IBA1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| IBA1
    ALZHEIMER["ALZHEIMER"] -->|"activates"| IBA1
    NLRP3["NLRP3"] -->|"inhibits"| IBA1
    UBIQUITIN["UBIQUITIN"] -->|"inhibits"| IBA1
    PARKINSON["PARKINSON"] -->|"inhibits"| IBA1
    SQSTM1["SQSTM1"] -->|"inhibits"| IBA1
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"inhibits"| IBA1

Outgoing (671)

Target	Relation	Type	Str
microglia	expressed_in	cell_type	0.95
microglia	expressed_in	cell_type	0.90
Microglia	biomarker_for	cell_type	0.90
MICROGLIA	biomarker_for	entity	0.90
Neuroinflammation	biomarker_for	process	0.85
Inflammation	activates	disease	0.85
astrocytes	expressed_in	cell_type	0.80
microglia	activates	cell_type	0.80
microglia	biomarker_for	cell_type	0.80
MICROGLIA	activates	cell_type	0.80
Alzheimer	inhibits	disease	0.75
Aging	activates	disease	0.75
Parkinson	activates	disease	0.75
Neurodegeneration	inhibits	disease	0.75
MICROGLIA	expresses	cell_type	0.70
PSD95	activates	gene	0.70
STING	expresses	gene	0.70
NRF2	markers	gene	0.70
MICROGLIA	markers	cell_type	0.70
TREM2	interacts_with	gene	0.70
SNAP25	regulates	gene	0.70
PSEN1	activates	gene	0.70
SQSTM1	associated_with	gene	0.70
LAMP1	degrades	gene	0.70
TNF	markers	gene	0.70
SYN1	regulates	gene	0.70
SYT1	regulates	gene	0.70
PDGF	associated_with	gene	0.70
TFEB	activates	gene	0.70
VAMP2	regulates	gene	0.70
SMPD1	interacts_with	gene	0.70
NLRP3	expresses	gene	0.70
PSEN1	regulates	gene	0.70
TLR4	activates	gene	0.70
MAPT	activates	gene	0.70
TAU	interacts_with	gene	0.70
ULK1	activates	gene	0.70
STING	protects_against	gene	0.70
MACROPHAGE	activates	cell_type	0.70
SQSTM1	activates	gene	0.70
LAMP1	activates	gene	0.70
PARP1	activates	gene	0.70
TREM2	protects_against	gene	0.70
TNF	expresses	gene	0.70
oxidative stress response	participates_in	pathway	0.70
Alzheimer's disease	regulates	disease	0.70
AMYLOID	inhibits	gene	0.70
Nf-Κb	activates	pathway	0.70
ASTROCYTES	activates	gene	0.70
NEURODEGENERATION	inhibits	gene	0.70

Incoming (452)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
Dark Microglia	expressed_in	phenotype	0.90
NEUROINFLAMMATION	associated_with	gene	0.90
Hearing Loss	upregulates	phenotype	0.90
TLR2	upregulates	gene	0.82
MICROGLIA	associated_with	cell_type	0.82
AMYLOID	associated_with	protein	0.82
HEARING_LOSS	upregulates	phenotype	0.80
GINSENOSIDE_RO	downregulates	compound	0.80
MICROGLIA	expressed_in	gene	0.74
PARKINSON'S DISEASE	associated_with	disease	0.74
APP	associated_with	gene	0.74
MICROGLIA	activates	gene	0.74
GFAP	degrades	gene	0.70
BACE1	degrades	gene	0.70
CSF1R	activates	gene	0.70
GFAP	expresses	gene	0.70
ASTROCYTE	markers	cell_type	0.70
CR1	markers	gene	0.70
GRIN2B	regulates	gene	0.70
GPX4	expresses	gene	0.70
ASTROCYTE	expresses	cell_type	0.70
FOXP3	activates	gene	0.70
BDNF	markers	gene	0.70
GFAP	markers	gene	0.70
AIF1	markers	gene	0.70
APP	expresses	gene	0.70
GFAP	disrupts	gene	0.70
APOE	regulates	gene	0.70
liver disease	associated_with	disease	0.70
MTOR	associated_with	gene	0.66
IL-6	associated_with	gene	0.66
TLR4	inhibits	gene	0.65
GFAP	interacts_with	gene	0.65
GFAP	accumulates_in	gene	0.65
NEURODEGENERATION	protects_against	disease	0.65
GFAP	biomarker_for	gene	0.65
AMYLOID	regulates	protein	0.65
DOPAMINERGIC	associated_with	cell_type	0.65
CD33	inhibits	gene	0.60
CD44	activates	gene	0.60
ANXIETY	activates	gene	0.60
GBM	expressed_in	gene	0.60
CR1	biomarker_for	gene	0.60
VCAM1	protects_against	gene	0.60
TMEM119	expressed_in	gene	0.60
BACE1	protects_against	gene	0.60
BECN1	disrupts	gene	0.60
CD68	expressed_in	gene	0.60
INFLAMMATION	activates	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Autophagy-Lysosomal Degradation of IBA1 in Stressed Microgli	0.706	neuroinflammation	What causes IBA1 low/negative microglia
Liver-Derived Inflammatory Suppressors Downregulate Microgli	0.633	neuroinflammation	What causes IBA1 low/negative microglia
Disease-Associated Microglia (DAM) Program Drives IBA1 Downr	0.571	neuroinflammation	What causes IBA1 low/negative microglia
Metabolic Accumulation (Ammonia/Manganese) Triggers IBA1 Dow	0.517	neuroinflammation	What causes IBA1 low/negative microglia
Circulating IBA1 Protein Absorption/Interference with Detect	0.507	neuroinflammation	What causes IBA1 low/negative microglia

Mentioning Analyses (1)

Scientific analyses that reference this entity

What causes IBA1 low/negative microglia in liver disease and how does this affec

neuroinflammation | 2026-04-07 | 7 hypotheses Top: 0.706

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Single-cell RNA sequencing analysis of microglial heterogeneity	exploratory	neurodegenerative diseases	0.700	0.00	human microglia	proposed	N/A
Analysis of IBA1 low/negative microglia in liver disease patients	exploratory	liver disease	0.600	0.00	human patients with liver dise	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract describes IBA1 low/negative microglia in individuals with liver dis

closed · Rounds: 4 · Score: 0.76 · 2026-04-21