| Gene Symbol | MAP2K4 |
| Full Name | Mitogen-Activated Protein Kinase Kinase 4 |
| Chromosome | 17p12 |
| Protein Type | Kinase |
| Function | is a dual-specificity protein kinase that serves as a critical node in cellular stress signaling. |
| Amino Acids | 399 aa |
| Pathways | MAPK pathway, MAPK |
| UniProt ID | [P45985](https://www.uniprot.org/uniprot/P45985) |
| Ensembl ID | ENSG00000157873 |
| GeneCards | MAP2K4 |
| Human Protein Atlas | MAP2K4 |
| N-terminal docking domain | For interaction with substrates and upstream kinases |
| Kinase domain | Catalytic core with dual-specificity |
| C-terminal regulatory region | Modulates interaction with scaffolds and localization |
| N-terminal D-domain | Conserved docking motif for interaction with upstream MAP3Ks and downstream MAPK substrates |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Databases | GeneCardsNCBI GeneHPASTRING |
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