concept

AUTOPHAGY_PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AUTOPHAGY_PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

1Hypotheses

5Analyses

15Outgoing

18Incoming

0Experiments

6Debates

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💡 Concept Info

Name	AUTOPHAGY_PATHWAY
Key Genes/Proteins	ATG5, M2_PROTEIN, MAVS, P62_SQSTM1
Related Diseases	ACUTE_KIDNEY_INJURY, APOPTOSIS, BRAIN_INFARCT, LYSOSOMAL_DYSFUNCTION, NEUROLOGICAL_DEFICITS
Related Pathways	AKT_MTOR, AUTOPHAGY_LYSOSOME, CGAS_STING, PI3K_AKT_MTOR

Pathway Diagram

graph TD
    AUTOPHAGY_PATHWAY["AUTOPHAGY_PATHWAY"]
    AUTOPHAGY_PATHWAY -->|"inhibits"| STING["STING"]
    AUTOPHAGY_PATHWAY -->|"regulates"| PEDV_N_protein["PEDV_N_protein"]
    AUTOPHAGY_PATHWAY -->|"inhibits"| CGAS_STING["CGAS_STING"]
    AUTOPHAGY_PATHWAY -->|"inhibits"| APOPTOSIS["APOPTOSIS"]
    AUTOPHAGY_PATHWAY -->|"regulates"| p62["p62"]
    AUTOPHAGY_PATHWAY -->|"regulates"| LC3["LC3"]
    AUTOPHAGY_PATHWAY -->|"contributes to"| ACUTE_KIDNEY_INJURY["ACUTE_KIDNEY_INJURY"]
    AUTOPHAGY_PATHWAY -->|"regulates"| MAVS["MAVS"]
    AKT_MTOR["AKT_MTOR"] -->|"regulates"| AUTOPHAGY_PATHWAY
    P62_SQSTM1["P62_SQSTM1"] -->|"regulates"| AUTOPHAGY_PATHWAY
    PI3K_AKT_MTOR["PI3K_AKT_MTOR"] -->|"regulates"| AUTOPHAGY_PATHWAY
    GNETUPENDIN_A["GNETUPENDIN_A"] -->|"activates"| AUTOPHAGY_PATHWAY
    AUTOPHAGY_LYSOSOME["AUTOPHAGY_LYSOSOME"] -->|"activates"| AUTOPHAGY_PATHWAY
    mTOR["mTOR"] -->|"inhibits"| AUTOPHAGY_PATHWAY
    ATG5["ATG5"] -->|"participates in"| AUTOPHAGY_PATHWAY
    METHAMPHETAMINE["METHAMPHETAMINE"] -->|"regulates"| AUTOPHAGY_PATHWAY

Outgoing (15)

Target	Relation	Type	Str
neurodegeneration	prevents	disease	0.80
neurodegeneration	dysfunction_causes	disease	0.80
STING	inhibits	protein	0.72
PEDV_N_protein	regulates	protein	0.72
tau_clearance	promotes	process	0.70
CGAS_STING	inhibits	pathway	0.64
APOPTOSIS	inhibits	phenotype	0.64
p62	regulates	protein	0.64
LC3	regulates	protein	0.64
angiogenesis	activates	phenotype	0.56
ACUTE_KIDNEY_INJURY	contributes_to	disease	0.56
inflammation	inhibits	phenotype	0.56
NEUROLOGICAL_DEFICITS	activates	phenotype	0.56
BRAIN_INFARCT	inhibits	phenotype	0.56
MAVS	regulates	protein	0.56

Incoming (18)

Source	Relation	Type	Str
ATG7	regulates	gene	0.90
FOXO3	activates	gene	0.80
FOXO1_protein	regulates	protein	0.80
ULK1	initiates	gene	0.80
mTOR	inhibits	protein	0.72
AKT_MTOR	regulates	pathway	0.72
P62_SQSTM1	regulates	protein	0.72
PI3K_AKT_MTOR	regulates	pathway	0.72
GNETUPENDIN_A	activates	drug	0.72
AUTOPHAGY_LYSOSOME	activates	pathway	0.72
ATG5	participates_in	protein	0.72
LGALS3	modulates	protein	0.70
ADAM8	inhibits	protein	0.64
THREE_MA	inhibits	drug	0.64
M2_PROTEIN	inhibits	protein	0.64
ATG5	regulates	protein	0.64
METHAMPHETAMINE	regulates	drug	0.64
LYSOSOMAL_DYSFUNCTION	inhibits	phenotype	0.56