concept

JAK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1531Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

JAK is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with ALS, Aging, Als. Connected to 853 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	JAK
Key Genes/Proteins	ABCB1, ABCG2, ABL1, ACHE, AD, AD RISK GENES
Related Diseases	Addiction, aging, Aging
Related Pathways	Adaptive Immunity, Akt
Linked Hypotheses	4 hypotheses

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    JAK["JAK"]
    JAK -->|"activates"| STAT3["STAT3"]
    JAK -->|"regulates"| GENE_EXPRESSION["GENE_EXPRESSION"]
    JAK -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    JAK -->|"target for"| Cardiovascular["Cardiovascular"]
    JAK -->|"target for"| Inflammation["Inflammation"]
    JAK -->|"target for"| Als["Als"]
    JAK -->|"target for"| Cancer["Cancer"]
    JAK -->|"target for"| Ms["Ms"]
    IL6["IL6"] -->|"activates"| JAK
    SOCS["SOCS"] -->|"inhibits"| JAK
    STAT3 -->|"activates"| JAK
    CD4["CD4"] -->|"target for"| JAK
    BCL2["BCL2"] -->|"target for"| JAK
    VIRAL_INFECTIONS["VIRAL INFECTIONS"] -->|"activates"| JAK
    STAT2["STAT2"] -->|"inhibits"| JAK
    MTOR["MTOR"] -->|"target for"| JAK

Outgoing (1030)

Target	Relation	Type	Str
Nf-Κb	activates	pathway	1.00
Als	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
Cancer	activates	disease	1.00
Tumor	therapeutic_target	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
h-cb2065e26c	targeted_by	hypothesis	1.00
Jak-Stat	activates	pathway	1.00
Inflammation	regulates	disease	1.00
Als	activates	disease	1.00
Inflammation	inhibits	disease	1.00
Als	inhibits	disease	1.00
Jak-Stat	inhibits	pathway	1.00
Mapk	activates	pathway	1.00
Tumor	activates	disease	0.95
Autoimmune	therapeutic_target	disease	0.95
Tumor	inhibits	disease	0.95
Cancer	associated_with	disease	0.95
Ph-Like ALL	involved_in	disease	0.95
Cancer	regulates	disease	0.95
STAT	activates	protein	0.95
Gene Expression	regulates	process	0.95
Als	treats	disease	0.95
Als	regulates	disease	0.95
neural stem cells	activates	cell_type	0.90
Chromatin	modulates	mechanism	0.90
inborn errors of immunity	associated_with	disease	0.90
JAK-STAT signaling	participates_in	pathway	0.90
NF-kB signaling	participates_in	pathway	0.90
Epigenome	modulates	mechanism	0.90
STAT3	phosphorylates	protein	0.90
STAT3	activates	protein	0.90
STAT3	associated_with	gene	0.90
Metastasis	therapeutic_target	pathway	0.90
Differentiation	therapeutic_target	pathway	0.90
Apoptosis	regulates	pathway	0.90
Differentiation	regulates	pathway	0.90
Tumor	regulates	disease	0.85
Alzheimer	therapeutic_target	disease	0.85
Neuroinflammation	activates	disease	0.85
Inflammation	causes	disease	0.85
Neuroinflammation	therapeutic_target	disease	0.85
Cardiovascular	therapeutic_target	disease	0.85
Neurodegeneration	activates	disease	0.85
Malignant Cell Proliferation	associated_with	phenotype	0.85
Malignant Cell Survival	associated_with	phenotype	0.85
PI3K-AKT-mTOR signaling	participates_in	pathway	0.80
TGF-beta signaling	participates_in	pathway	0.80
microglia	expressed_in	cell_type	0.80

Incoming (501)

Source	Relation	Type	Str
h-cb2065e26c	targets	hypothesis	1.00
INFLAMMATION	therapeutic_target	gene	1.00
IL-6	therapeutic_target	gene	1.00
STAT3	therapeutic_target	gene	1.00
INFLAMMATION	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
CYTOKINES	inhibits	gene	1.00
ERK	activates	gene	1.00
IL-6	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
NF-KB	associated_with	gene	0.98
RAS	activates	gene	0.90
CYTOKINES	therapeutic_target	gene	0.90
NF-ΚB	activates	gene	0.90
INFLAMMATION	regulates	gene	0.90
CANCER	activates	gene	0.90
CANCER	regulates	gene	0.90
INFLAMMATION	inhibits	gene	0.90
IL6	activates	protein	0.87
IL-6	associated_with	gene	0.82
SOCS	inhibits	protein	0.80
Polyphenols	inhibits	compound	0.80
OXIDATIVE STRESS	activates	gene	0.80
CYTOKINES	activates	gene	0.80
TNF	inhibits	gene	0.80
IL-6	inhibits	gene	0.80
TNF-Α	inhibits	gene	0.80
AMPK	activates	gene	0.80
AKT	regulates	gene	0.80
INFLAMMATION	causes	gene	0.80
AKT	associated_with	gene	0.80
GENES	activates	gene	0.80
CANCER	associated_with	gene	0.80
TNF-Α	activates	gene	0.80
PI3K	associated_with	gene	0.80
GENES	inhibits	gene	0.80
CANCER	inhibits	disease	0.80
STAT3	activates	protein	0.74
AMYLOID	associated_with	protein	0.74
TNF	associated_with	gene	0.74
ASTROCYTE	enhances	cell_type	0.70
APOE	regulates	gene	0.70
CSF1R	activates	gene	0.70
ACHE	markers	gene	0.70
ACHE	inhibits	gene	0.70
DOPAMINERGIC	inhibits	cell_type	0.70
DOPAMINERGIC	activates	cell_type	0.70
AMPK	interacts_with	gene	0.70
ASTROCYTE	expressed_in	cell_type	0.70
NRF2	inhibits	gene	0.70

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
H2: SASP Neutralization via JAK/STAT Inhibition Preserves As	0.550	neurodegeneration	Do APOE4-driven senescent astrocytes cau
CNTF-JAK/STAT3 Reprogramming of Trained Microglia to Neuropr	0.522	neuroinflammation	What specific astrocyte-derived factors
α4β1 Integrin (VLA-4) and JAK/STAT Pathway	0.450	neuroinflammation	What molecular mechanisms mediate SPP1-i

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning JAK in their description or question text

No additional research found

JAK

Understanding Entity Pages

Summary

Wiki Pages (13)

JAK-STAT Signaling Pathway in Neurodegeneration

JAK-STAT and Cytokine Signaling in 4R-Tauopathies

JAK-STAT Signaling in Parkinson's Disease

JAK2 Gene - Janus Kinase 2

JAK3 Gene

JAK-STAT Signaling Pathway in Neurodegeneration

MAPK/ERK and JAK-STAT Signaling in 4R-Tauopathies

JAK Inhibitors in Parkinson's Disease

AD JAK-STAT Inhibitor Companies

JAK/STAT Inhibitors for Neurodegeneration

JAK1 Protein — Janus Kinase 1

JAK2 Protein

JAK1 — Janus Kinase 1