gene

CSNK2A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSNK2A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

58Connections

0Hypotheses

0Analyses

44Outgoing

14Incoming

0Experiments

0Debates

Summary

CSNK2A1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Alzheimer. Connected to 40 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CSNK2A1
Chromosome	20p13
Function	Catalytic activity: α and α' subunits provide kinase activity
Primary Expression	hippocampus, cortex, and cerebellum
Amino Acids	350 aa
Exons	10
Pathways	Notch
Ensembl ID	ENSG00000101266
GeneCards	CSNK2A1
Human Protein Atlas	CSNK2A1
Heterotetramer formation	Combines with regulatory β subunits (CSNK2B) to form α₂β₂ or αα'β₂ holoenzymes
Constitutive activity	Unlike most kinases, CK2 is constitutively active without requiring phosphorylation
Ubiquitous expression	High levels in brain, particularly in neurons
Ser202/Thr205	AT8 epitope (also GSK3β, CDK5 targets)
Ser396/Ser404	PHF-1 epitope
Associated Diseases	Als, Alzheimer, Alzheimer's Disease, Ms, Neurodegeneration, Parkinson
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, App, HNRNPA2B1, NEURODEGENERATION, TAU
KG Connections	58 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CSNK2A1 Gene

gene · 788 words

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Pathway Diagram

graph TD
    CSNK2A1["CSNK2A1"]
    Neurodegeneration{"Neurodegeneration"}
    CSNK2A1 -->|"activates"| Neurodegeneration
    Alzheimer{"Alzheimer"}
    CSNK2A1 -->|"activates"| Alzheimer
    Ms{"Ms"}
    CSNK2A1 -->|"activates"| Ms
    Als{"Als"}
    CSNK2A1 -->|"activates"| Als
    Parkinson{"Parkinson"}
    CSNK2A1 -->|"associated with"| Parkinson
    CSNK2A1 -->|"associated with"| Als
    CSNK2A1 -->|"associated with"| Ms
    CSNK2A1 -->|"associated with"| Alzheimer
    CSNK2A1 -->|"associated with"| Neurodegeneration
    ALS{"ALS"}
    CSNK2A1 -->|"activates"| ALS
    NOTCH1["NOTCH1"]
    CSNK2A1 -->|"regulates"| NOTCH1
    Notch(["Notch"])
    CSNK2A1 -->|"regulates"| Notch
    HNRNPA2B1["HNRNPA2B1"]
    HNRNPA2B1 -->|"activates"| CSNK2A1
    STX4["STX4"]
    STX4 -->|"associated with"| CSNK2A1
    LDLR["LDLR"]
    LDLR -->|"associated with"| CSNK2A1
    HSPB1["HSPB1"]
    HSPB1 -->|"associated with"| CSNK2A1
    APOA2["APOA2"]
    APOA2 -->|"associated with"| CSNK2A1
    LGALS3["LGALS3"]
    LGALS3 -->|"associated with"| CSNK2A1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| CSNK2A1
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    NEURODEGENERATIVE_DISORDERS -->|"associated with"| CSNK2A1
    DNA["DNA"]
    DNA -->|"regulates"| CSNK2A1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| CSNK2A1
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| CSNK2A1
    style CSNK2A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (44)

Target	Relation	Type	Str
DNA Damage	regulates	process	0.85
Alzheimer's Disease	associated_with	disease	0.75
Neurodegeneration	associated_with	disease	0.75
Neural Progenitor Cells	expressed_in	cell_type	0.70
ALS	activates	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
App	activates	protein	0.60
Neural Progenitor	regulates	cell_type	0.60
NEURODEGENERATION	activates	gene	0.60
Tau Protein	activates	protein	0.60
oxidative stress response	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.60
LGALS3	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
STX4	associated_with	gene	0.60
Notch	regulates	pathway	0.60
DNA	regulates	gene	0.60
ALZHEIMER	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
Stem Cell	regulates	cell_type	0.60
Neuron	activates	cell_type	0.60
NOTCH1	regulates	gene	0.60
HNRNPA2B1	associated_with	gene	0.60
TAU	activates	gene	0.60
HNRNPA2B1	activates	gene	0.60
HSPB1	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
Stem Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
Progenitor Cell	expressed_in	cell_type	0.55
DNA DAMAGE	regulates	concept	0.50
HNRNPA2B1	co_discussed	gene	0.50
NOTCH1	co_discussed	gene	0.50
TAU	co_discussed	protein	0.50
ALZHEIMER	regulates	gene	0.50
NEURON	co_discussed	gene	0.50

Incoming (14)

Source	Relation	Type	Str
DNA	regulates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
STX4	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
APOA2	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
NOTCH1	regulates	gene	0.60
TAU	activates	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
HSPB1	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
HNRNPA2B1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CSNK2A1 in their description or question text

No additional research found