gene

ERK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

943Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ERK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with AD, ALI, ALS. Connected to 498 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ERK1
Chromosome	16p11.2
Protein Type	Kinase
Function	is a serine/threonine protein kinase that plays a central role in intracellular signal transduction.
Primary Expression	various tissues, with particularly high levels in the brain where it participates in learning, memory, and neuronal plasticity
Molecular Weight	44 kDa
Amino Acids	402 aa
Pathways	Akt, Apoptosis, Differentiation, G-Protein Coupled Receptor, Hedgehog
Ensembl ID	ENSG00000102882
GeneCards	ERK1
Human Protein Atlas	ERK1
Associated Diseases	AD, Aging, ALI, Als, Alzheimer, AMI
Known Drugs/Compounds	curcumin, metformin, rapamycin
Interactions	6-OHDA, ACSL4, AGING, AKT, AKT1, ALZHEIMER
KG Connections	943 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ERK1["ERK1"] -->|"activates"| Aging["Aging"]
    ERK1["ERK1"] -->|"interacts"| Cancer["Cancer"]
    ERK1["ERK1"] -->|"activates"| Ms["Ms"]
    ERK1["ERK1"] -->|"activates"| Als["Als"]
    ERK1["ERK1"] -->|"activates"| Alzheimer["Alzheimer"]
    ERK1["ERK1"] -.->|"inhibits"| Diabetes["Diabetes"]
    HSPA1A["HSPA1A"] -.->|"inhibits"| ERK1["ERK1"]
    FGF1["FGF1"] -->|"interacts"| ERK1["ERK1"]
    PRDX1["PRDX1"] -->|"activates"| ERK1["ERK1"]
    DNA["DNA"] -->|"activates"| ERK1["ERK1"]
    style ERK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (672)

Target	Relation	Type	Str
ERK	activates	gene	1.00
Cancer	activates	disease	1.00
Mapk	activates	pathway	1.00
Als	activates	disease	1.00
JNK	activates	gene	1.00
Oxidative Stress	activates	pathway	1.00
P38	activates	gene	1.00
AKT	activates	gene	1.00
Differentiation	activates	pathway	0.90
Apoptosis	activates	pathway	0.90
OXIDATIVE STRESS	activates	gene	0.90
PI3K	activates	gene	0.90
CANCER	activates	gene	0.90
Cancer	therapeutic_target	disease	0.85
Cardiac	activates	disease	0.85
Tumor	activates	disease	0.85
Alzheimer	activates	disease	0.85
Als	therapeutic_target	disease	0.85
Inflammation	activates	disease	0.85
Als	inhibits	disease	0.85
Cancer	regulates	disease	0.85
MAPK signaling	participates_in	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
JUN	activates	gene	0.80
Erk Signaling	activates	pathway	0.80
Apoptosis	regulates	pathway	0.80
Mapk	therapeutic_target	pathway	0.80
ERK	regulates	gene	0.80
AUTOPHAGY	activates	gene	0.80
Autophagy	activates	pathway	0.80
TNF-Α	activates	gene	0.80
C-JUN	activates	gene	0.80
APOPTOSIS	activates	gene	0.80
TNF	activates	gene	0.80
ALZHEIMER	activates	gene	0.80
Apoptosis	inhibits	pathway	0.80
P38	regulates	gene	0.80
ERK2	activates	gene	0.80
Inflammation	inhibits	disease	0.75
Neurodegeneration	regulates	disease	0.75
Glioblastoma	activates	disease	0.75
Melanoma	therapeutic_target	disease	0.75
Lymphoma	activates	disease	0.75
Inflammation	regulates	disease	0.75
Als	regulates	disease	0.75
Neurodegeneration	activates	disease	0.75
Tumor	inhibits	disease	0.75
Ischemia	regulates	disease	0.75
Cardiovascular	activates	disease	0.75
Carcinoma	activates	disease	0.75

Incoming (271)

Source	Relation	Type	Str
KPNA2	interacts_with	protein	0.93
TLR2	therapeutic_target	gene	0.60
ERK2	associated_with	gene	0.60
APP	activates	gene	0.60
RANK	activates	gene	0.60
DLK	activates	gene	0.60
APOE	activates	gene	0.60
CFOS	activates	gene	0.60
APOE4	activates	gene	0.60
AKT	phosphorylates	entity	0.60
CSF1R	activates	gene	0.60
AQP4	inhibits	gene	0.60
SMPD1	regulates	gene	0.60
PKC	associated_with	gene	0.60
GAIN	regulates	gene	0.60
EPHA8	associated_with	gene	0.60
P38	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
BDNF	activates	gene	0.60
SYNAPTOPHYSIN	activates	gene	0.60
MTOR	regulates	gene	0.60
curcumin	inhibits	compound	0.60
curcumin	activates	compound	0.60
curcumin	protects_against	compound	0.60
BDNF	regulates	gene	0.60
BDNF	interacts_with	gene	0.60
curcumin	targets	drug	0.60
SOD1	activates	gene	0.60
CDK5	activates	gene	0.60
ERK	inhibits	gene	0.60
MYOD	inhibits	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
AND	inhibits	gene	0.60
C-MYC	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
MAPK	expressed_in	gene	0.60
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.60
AGING	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
HSPB1	expressed_in	gene	0.60
EXOSOMES	expressed_in	gene	0.60
SYNAPSE	expressed_in	gene	0.60
STROKE	activates	gene	0.60
BCL-2	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
ARAF	implicated_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

ERK1

Understanding Entity Pages

Summary

Wiki Pages (6)

ERK1 Protein

ERK1 Protein

ERK1 (MAPK3) — Extracellular Signal-Regulated Kinase 1

MAPK3 Gene - ERK1

ERK1 Protein

MAPK3 Protein (ERK1)

Pathway Diagram

Outgoing (672)

Incoming (271)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)

Debates (0)