concept

THERAPEUTIC_TARGET

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about THERAPEUTIC_TARGET: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

6Hypotheses

0Analyses

0Outgoing

40Incoming

0Experiments

0Debates

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💡 Concept Info

Name	THERAPEUTIC_TARGET

Pathway Diagram

graph TD
    THERAPEUTIC_TARGET["THERAPEUTIC_TARGET"]
    IDH2["IDH2"] -->|"target for"| THERAPEUTIC_TARGET
    MTOR["MTOR"] -->|"target for"| THERAPEUTIC_TARGET
    AQP4["AQP4"] -->|"target for"| THERAPEUTIC_TARGET
    TGM2["TGM2"] -->|"target for"| THERAPEUTIC_TARGET
    P2RX1["P2RX1"] -->|"target for"| THERAPEUTIC_TARGET
    P2RX4["P2RX4"] -->|"target for"| THERAPEUTIC_TARGET
    P2RX7["P2RX7"] -->|"target for"| THERAPEUTIC_TARGET
    P2RY1["P2RY1"] -->|"target for"| THERAPEUTIC_TARGET

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (40)

Source	Relation	Type	Str
IDH2	therapeutic_target	entity	0.95
P2RY11	therapeutic_target	entity	0.90
P2RY14	therapeutic_target	entity	0.90
TREM2	therapeutic_target	gene	0.90
P2RX7	therapeutic_target	entity	0.90
BCL-2	therapeutic_target	protein	0.90
SOAT1	therapeutic_target	entity	0.90
MTOR	therapeutic_target	entity	0.90
AQP4	therapeutic_target	entity	0.90
TGM2	therapeutic_target	entity	0.90
P2RX1	therapeutic_target	entity	0.90
P2RX4	therapeutic_target	entity	0.90
P2RY1	therapeutic_target	entity	0.90
CTSB	involved_in	gene	0.88
EGFR	therapeutic_target	gene	0.88
PI3K	biomarker_for	protein	0.88
HCN1	therapeutic_target	gene	0.85
PRMT1	associated_with	entity	0.85
Hcrtr2	therapeutic_target	protein	0.85
LNK	involved_in	protein	0.85
TGM2	associated_with	gene	0.85
PPARG	associated_with	entity	0.85
SLC16A1	therapeutic_target	entity	0.85
PANoptosome	therapeutic_target	process	0.85
HSPA5	therapeutic_target	entity	0.80
PRKCG	targets	gene	0.80
Hcrtr1	therapeutic_target	protein	0.80
FCGRT	therapeutic_target	entity	0.80
RAS	serves_as	protein	0.80
Plasma proteins	therapeutic_target	protein	0.75
DGAT1	therapeutic_target	gene	0.70
BRAF	therapeutic_target	gene	0.65
SLC1A3	therapeutic_target	gene	0.60
P2RY12	therapeutic_target	gene	0.60
SORL1	therapeutic_target	gene	0.60
SHIP1	therapeutic_target	protein	0.60
P2RX7	therapeutic_target	gene	0.60
APP	therapeutic_target	gene	0.60
CLU	therapeutic_target	gene	0.60
PSEN1	therapeutic_target	gene	0.60

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TDP-43 condensation thermodynamics as a therapeutic target a	0.710	neuroscience	How can subcellular compartmentalization
CLU-APOE-TREM2 Tripartite Axis as a Coordinate Therapeutic T	0.648	neurodegeneration	Does clusterin exacerbate or protect aga
LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target	0.594	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M
Temporal cGAS-STING Activation Stage-Specific Therapeutic Ta	0.560	neuroinflammation	How does chronic cGAS/STING activation d
MAP6-mediated microtubule stabilization as therapeutic targe	0.500	neurodegeneration	View

AQP4 Water Channel Normalization as Surrogate Marker and The	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Chrysophanol Attenuates Cognitive Impairment, Neuroinflammation, and Oxidative S [PMID:40728692]	Khan JZ, Zainab SR, Alattar A	Neurochem Res	2025
Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR [PMID:38184025]	Unknown	Journal of ethnopharmacology	2024
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microgl [PMID:37466915]	Sun W, Wang Q, Zhang R, Zhang N	Food & function	2023
NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via [PMID:37137264]	Ibrahim Weam W; Skalicka-Woźniak K	International immunopharmacolo	2023
Microglia clear neuron-released α-synuclein via selective autophagy and prevent [PMID:32170061]	Choi I, Zhang Y, Seegobin SP	Nat Commun	2020
Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction throug [PMID:32622362]	Mondal A, Bose D, Saha P	J Neuroinflammation	2020
RETRACTED: Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammat [PMID:30884890]	["Muhammad T", "Ikram M", "Ullah R", "Re	Nutrients	2019

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning THERAPEUTIC_TARGET in their description or question text

AQP4 Water Channel Normalization as Surrogate Marker and Therapeutic Target

Score: 0.105 · neurodegeneration · 2026-04-18

## Mechanistic Overview AQP4 Water Channel Normalization as Surrogate Marker and Therapeutic Target starts from the clai