gene

ITPR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ITPR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

15Outgoing

15Incoming

0Experiments

0Debates

Summary

Page for ITPR1 - Inositol 1,4,5-Trisphosphate Receptor Type 1

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🧬 Gene Info

Gene Symbol	ITPR1
Full Name	Inositol 1,4,5-Trisphosphate Receptor Type 1
Aliases	Page for ITPR1
Chromosome	3p26.1
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	300 kDa
Amino Acids	700 aa
Exons	58
Pathways	Calcium Dysregulation
UniProt ID	[Q14643](https://www.uniprot.org/uniprot/Q14643)
Ensembl ID	ENSG00000151952
GeneCards	ITPR1
Human Protein Atlas	ITPR1
IP3 binding	Cooperative binding at N-terminus triggers conformational change
Associated Diseases	Diabetes, stroke
KG Connections	30 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ITPR1 - Inositol 1,4,5-Trisphosphate Receptor Type 1

gene · 1135 words

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ITPR1 Gene

protein · 737 words

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Pathway Diagram

graph TD
    ITPR1["ITPR1"]
    Atherosclerosis{"Atherosclerosis"}
    ITPR1 -->|"expressed in"| Atherosclerosis
    Diabetes{"Diabetes"}
    ITPR1 -->|"associated with"| Diabetes
    MAP1LC3B["MAP1LC3B"]
    ITPR1 -->|"expressed in"| MAP1LC3B
    GENES["GENES"]
    ITPR1 -->|"expressed in"| GENES
    TIMP1["TIMP1"]
    ITPR1 -->|"expressed in"| TIMP1
    Autophagy(["Autophagy"])
    ITPR1 -->|"expressed in"| Autophagy
    WIPI1["WIPI1"]
    ITPR1 -->|"associated with"| WIPI1
    ITPR1 -->|"associated with"| Autophagy
    Mitophagy(["Mitophagy"])
    ITPR1 -->|"associated with"| Mitophagy
    AND["AND"]
    ITPR1 -->|"expressed in"| AND
    AUTOPHAGY["AUTOPHAGY"]
    ITPR1 -->|"expressed in"| AUTOPHAGY
    neurodegeneration["neurodegeneration"]
    ITPR1 -->|"implicated in"| neurodegeneration
    IL12B["IL12B"]
    IL12B -->|"expressed in"| ITPR1
    RAB7A["RAB7A"]
    RAB7A -->|"associated with"| ITPR1
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"associated with"| ITPR1
    GABARAPL2["GABARAPL2"]
    GABARAPL2 -->|"associated with"| ITPR1
    FOXO3["FOXO3"]
    FOXO3 -->|"associated with"| ITPR1
    LAMP2["LAMP2"]
    LAMP2 -->|"associated with"| ITPR1
    DIABETES_MELLITUS["DIABETES MELLITUS"]
    DIABETES_MELLITUS -->|"associated with"| ITPR1
    RB1CC1["RB1CC1"]
    RB1CC1 -->|"associated with"| ITPR1
    AUTOPHAGY -->|"associated with"| ITPR1
    EIF2AK3["EIF2AK3"]
    EIF2AK3 -->|"associated with"| ITPR1
    GAPDH["GAPDH"]
    GAPDH -->|"associated with"| ITPR1
    AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
    AUTOPHAGY_RELATED_GENES -->|"associated with"| ITPR1
    style ITPR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
Atherosclerosis	expressed_in	disease	0.65
Diabetes	associated_with	disease	0.65
stroke	activates	disease	0.60
stroke	inhibits	disease	0.60
stroke	implicated_in	disease	0.60
Autophagy	associated_with	pathway	0.60
Mitophagy	associated_with	pathway	0.60
MAP1LC3B	expressed_in	gene	0.60
TIMP1	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
pyroptosis	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
WIPI1	associated_with	gene	0.60
Autophagy	expressed_in	pathway	0.60
AUTOPHAGY	expressed_in	gene	0.60

Incoming (15)

Source	Relation	Type	Str
MITOPHAGY	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AUTOPHAGY-RELATED GENES	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
IL12B	expressed_in	gene	0.60
RAB7A	associated_with	gene	0.60
GABARAPL2	associated_with	gene	0.60
FOXO3	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
EIF2AK3	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
HSPA5	associated_with	gene	0.60
MAP1LC3B	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ITPR1 in their description or question text

No additional research found