protein

GADD45A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GADD45A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

33Outgoing

3Incoming

0Experiments

0Debates

Summary

GADD45A is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with Als, Depression, Hypertension. Connected to 36 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	GADD45A
Function	GADD45A is a small (165 aa) acidic protein that responds to various cellular stresses
Molecular Weight	18.5 kDa
Amino Acids	165 aa
Pathways	MAPK pathway, NF-κB
Ensembl ID	ENSG00000116729
GeneCards	GADD45A
Human Protein Atlas	GADD45A
Associated Diseases	Als
Interactions	ACHE, GADD45B, GADD45G, INFLAMMATION, MET
KG Connections	36 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GADD45A Gene

gene · 662 words

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GADD45A Protein

protein · 641 words

→

Pathway Diagram

graph TD
    GADD45A["GADD45A"]
    Ms{"Ms"}
    GADD45A -->|"activates"| Ms
    Depression{"Depression"}
    GADD45A -->|"activates"| Depression
    GADD45A -->|"expressed in"| Ms
    Als{"Als"}
    GADD45A -->|"activates"| Als
    Inflammation{"Inflammation"}
    GADD45A -->|"activates"| Inflammation
    GADD45A -->|"regulates"| Ms
    Hypertension{"Hypertension"}
    GADD45A -->|"expressed in"| Hypertension
    GADD45B["GADD45B"]
    GADD45A -->|"activates"| GADD45B
    GADD45G["GADD45G"]
    GADD45A -->|"activates"| GADD45G
    MET["MET"]
    GADD45A -->|"activates"| MET
    Neurogenesis(["Neurogenesis"])
    GADD45A -->|"activates"| Neurogenesis
    GADD45A -->|"regulates"| GADD45B
    ACHE["ACHE"]
    ACHE -->|"activates"| GADD45A
    P62["P62"]
    P62 -->|"biomarker for"| GADD45A
    MMP9["MMP9"]
    MMP9 -->|"regulates"| GADD45A
    style GADD45A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (33)

Target	Relation	Type	Str
myofiber degeneration	promotes	phenotype	0.85
Ms	activates	disease	0.65
Depression	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	expressed_in	disease	0.65
Ms	regulates	disease	0.65
Hypertension	expressed_in	disease	0.65
Als	activates	disease	0.65
Als	causes	disease	0.65
ACHE	activates	gene	0.60
ACHE	causes	gene	0.60
P62	biomarker_for	gene	0.60
GADD45B	activates	gene	0.60
GADD45G	activates	gene	0.60
MET	activates	gene	0.60
GADD45B	regulates	gene	0.60
GADD45G	regulates	gene	0.60
JUN	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
CEBPB	associated_with	gene	0.60
HSPA5	associated_with	gene	0.60
DDIT3	associated_with	gene	0.60
H3F3B	associated_with	gene	0.60
Neurogenesis	activates	pathway	0.60
Epigenetic	expressed_in	pathway	0.60
Dna Methylation	expressed_in	pathway	0.60
INFLAMMATION	activates	gene	0.60
IMMUNE INFILTRATION	regulates	gene	0.60
Mapk	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
MAPK14	regulates	gene	0.60
VIM	regulates	gene	0.60
CTSD	regulates	gene	0.60

Incoming (3)

Source	Relation	Type	Str
P62	biomarker_for	gene	0.60
MMP9	regulates	gene	0.60
ACHE	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GADD45A in their description or question text

No additional research found