gene

WIPI1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WIPI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

84Connections

0Hypotheses

0Analyses

27Outgoing

50Incoming

0Experiments

0Debates

Summary

WIPI1 (WD Repeat Domain, Pyrin Interacting 1) is a PROPPIN family protein involved in autophagy, particularly in the formation of omegasomes and autophagosomes. It plays critical roles in cellular homeostasis and is implicated in neurodegenerative dise...

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🧬 Gene Info

Gene Symbol	WIPI1
Aliases	WD Repeat Domain, Pyrin Interacting 1
Chromosome	1p34.2
Protein Type	Gene
Function	WIPI1 localizes to the edges of the omegasome and is essential for the recruitment of downstream autophagy proteins (Proikas-Cezanne et al., 2004).
Molecular Weight	49 kDa
Amino Acids	449 aa
Exons	10
Pathways	Autophagy, Mitophagy, autophagy pathway, ubiquitin-proteasome
GeneCards	WIPI1
Human Protein Atlas	WIPI1
Phosphorylation	Multiple serine/threonine phosphorylation sites regulate WIPI1 activity and localization
Acetylation	Lysine acetylation modulates protein-protein interactions
Ubiquitination	May target WIPI1 for degradation under certain conditions
Associated Diseases	Als, Diabetes, Ms
Interactions	AMPK, AND, ATG, ATG16L1, AUTOPHAGY, BECN1
KG Connections	84 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    WIPI1["WIPI1"] -->|"interacts with"| Als["Als"]
    WIPI1["WIPI1"] -->|"activates"| Als["Als"]
    WIPI1["WIPI1"] -->|"associated with"| Als["Als"]
    WIPI1["WIPI1"] -->|"associated with"| Ms["Ms"]
    WIPI1["WIPI1"] -->|"associated with"| Diabetes["Diabetes"]
    WIPI1["WIPI1"] -->|"interacts with"| ALS["ALS"]
    NDP52["NDP52"] -->|"recruits"| WIPI1["WIPI1"]
    WIPI1["WIPI1"] -->|"interacts with"| Mitophagy["Mitophagy"]
    WIPI1["WIPI1"] -->|"interacts with"| Autophagy["Autophagy"]
    WIPI1["WIPI1"] -->|"interacts with"| PARKIN["PARKIN"]
    WIPI1["WIPI1"] -->|"interacts with"| NDP52["NDP52"]
    WIPI1["WIPI1"] -->|"interacts with"| LC3["LC3"]
    style WIPI1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style NDP52 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Mitophagy fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#333,color:#e0e0e0
    style PARKIN fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style LC3 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Diabetes	associated_with	disease	0.65
Als	activates	disease	0.65
Mitophagy	associated_with	pathway	0.60
Autophagy	activates	pathway	0.60
AND	interacts_with	gene	0.60
ALS	associated_with	disease	0.60
MITOPHAGY	interacts_with	gene	0.60
Mitophagy	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
Mitophagy	activates	pathway	0.60
AUTOPHAGY	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
Autophagy	associated_with	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
ULK1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	protein	0.50

Incoming (57)

Source	Relation	Type	Str
NDP52	recruits	protein	0.64
RAB7A	associated_with	gene	0.60
GABARAPL2	associated_with	gene	0.60
FOXO3	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
EIF2AK3	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
HSPA5	associated_with	gene	0.60
ITPR1	associated_with	gene	0.60
MIRNAS	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AUTOPHAGY-RELATED GENES	associated_with	gene	0.60
PARKIN	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
ROCK	inhibits	gene	0.60
ERK	activates	gene	0.60
ATG	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AMPK	activates	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
ULK1	associated_with	entity	0.60
PARKIN	activates	gene	0.60
PINK1	activates	gene	0.60
P62	activates	gene	0.60
LC3	associated_with	entity	0.60
OPTINEURIN	associated_with	entity	0.60
AND	interacts_with	gene	0.60
CD8	associated_with	gene	0.60
LRRK2	expressed_in	gene	0.60
GBA	therapeutic_target	gene	0.60
WDFY3	expressed_in	gene	0.60
PIK3CB	expressed_in	gene	0.60
RALB	expressed_in	gene	0.60
GNAI3	expressed_in	gene	0.60
ATG16L1	interacts_with	gene	0.60
MYC	activates	gene	0.60
GABARAP	interacts_with	gene	0.60
WIPI3	activates	gene	0.60
WIPI2	interacts_with	gene	0.60
WIPI4	activates	gene	0.60
UBIQUITIN	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WIPI1 in their description or question text

No additional research found