gene

GABARAPL2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABARAPL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

125Connections

0Hypotheses

0Analyses

50Outgoing

38Incoming

0Experiments

0Debates

Summary

GABARAPL2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Alzheimer. Connected to 97 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GABARAPL2
Chromosome	16q24.1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	various tissues:
Molecular Weight	16 kDa
Amino Acids	117 aa
Exons	7
Pathways	Autophagy
GeneCards	GABARAPL2
Human Protein Atlas	GABARAPL2
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Dementia, Diabetes, Frontotemporal Dementia
Interactions	AND, ATG, AUTOPHAGY, BNIP3, CANCER, GABARAP
KG Connections	125 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GABARAPL2["GABARAPL2"] -->|"activates"| Cancer["Cancer"]
    GABARAPL2["GABARAPL2"] -->|"activates"| Als["Als"]
    GABARAPL2["GABARAPL2"] -->|"regulates"| Als_1["Als"]
    GABARAPL2["GABARAPL2"] -->|"regulates"| Cancer_2["Cancer"]
    GABARAPL2["GABARAPL2"] -->|"regulates"| Alzheimer["Alzheimer"]
    GABARAPL2["GABARAPL2"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    ATG["ATG"] -->|"activates"| GABARAPL2["GABARAPL2"]
    GABARAP["GABARAP"] -->|"activates"| GABARAPL2["GABARAPL2"]
    BNIP3["BNIP3"] -->|"activates"| GABARAPL2["GABARAPL2"]
    SIRT5["SIRT5"] -->|"activates"| GABARAPL2["GABARAPL2"]
    style GABARAPL2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (87)

Target	Relation	Type	Str
autophagosome-lysosome fusion	regulates	process	0.92
Als	associated_with	disease	0.75
Ms	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Breast Cancer	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Diabetes	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
CANCER	expressed_in	gene	0.60
LC3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
FOXO3	associated_with	gene	0.60
LAMP2	expressed_in	gene	0.60
RB1CC1	expressed_in	gene	0.60
EIF2AK3	expressed_in	gene	0.60
GAPDH	associated_with	gene	0.60
HSPA5	expressed_in	gene	0.60
ITPR1	associated_with	gene	0.60
WIPI1	associated_with	gene	0.60
SNX2	expressed_in	gene	0.60
ATG10	expressed_in	gene	0.60
WIPI2	expressed_in	gene	0.60
GABARAP	activates	gene	0.60
TBK1	regulates	gene	0.60
MAP1LC3B	biomarker_for	entity	0.60
PARK2	biomarker_for	entity	0.60
PINK1	biomarker_for	entity	0.60
Mitophagy	activates	pathway	0.60
Autophagy	activates	pathway	0.60
T Cell	activates	cell_type	0.60
AND	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
P62	associated_with	gene	0.60
AUTOPHAGY-RELATED GENES	associated_with	gene	0.60
CANCER	regulates	gene	0.60

Incoming (38)

Source	Relation	Type	Str
SIK2	phosphorylates	gene	0.95
GABARAPL1	associated_with	gene	0.70
LC3B	associated_with	gene	0.70
ATG	activates	gene	0.70
GABARAP	biomarker_for	entity	0.60
SQSTM1	phosphorylates	gene	0.60
MITOPHAGY	associated_with	gene	0.60
ATG8	associated_with	gene	0.60
AUTOPHAGY	implicated_in	gene	0.60
ENDOSOME	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
BNIP3	biomarker_for	entity	0.60
ALS	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
GABARAP	activates	gene	0.60
BNIP3	activates	gene	0.60
SIRT5	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
PINK1	activates	gene	0.60
UVRAG	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
CANCER	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
RAB7A	associated_with	gene	0.60
CLN3	expressed_in	gene	0.60
PARK2	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
SQSTM1	regulates	gene	0.60
OPTN	associated_with	gene	0.60
RAB7A	regulates	gene	0.60
P62	regulates	gene	0.60
LC3	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
BNIP3	co_expressed_with	gene	0.50
GABARAP	co_expressed_with	protein	0.50
Autophagy	activates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GABARAPL2 in their description or question text

No additional research found