gene

H3F3B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about H3F3B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

1Outgoing

6Incoming

0Experiments

0Debates

Summary

H3F3B Gene — H3.3 Histone B

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🧬 Gene Info

Gene Symbol	H3F3B
Full Name	H3.3 Histone B
Chromosome	17q25.1
Protein Family	H3 histone family (Replication-independent histone variant)
Function	encodes histone H3.3B, a replication-independent histone variant that is incorporated into chromatin throughout the cell cycle
Primary Expression	most tissues, with particularly high expression in:
Amino Acids	136 aa
UniProt ID	[P84243](https://www.uniprot.org/uniprot/P84243)
Ensembl ID	ENSG00000183520
GeneCards	H3F3B
Human Protein Atlas	H3F3B
Associated Diseases	neurodegeneration
KG Connections	7 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

H3F3B Gene — H3.3 Histone B

gene · 2806 words

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Pathway Diagram

graph TD
    H3F3B["H3F3B"]
    Hypertension{"Hypertension"}
    H3F3B -->|"expressed in"| Hypertension
    neurodegeneration["neurodegeneration"]
    H3F3B -->|"implicated in"| neurodegeneration
    GADD45A["GADD45A"]
    GADD45A -->|"associated with"| H3F3B
    JUN["JUN"]
    JUN -->|"associated with"| H3F3B
    HSPA8["HSPA8"]
    HSPA8 -->|"associated with"| H3F3B
    CEBPB["CEBPB"]
    CEBPB -->|"associated with"| H3F3B
    HSPA5["HSPA5"]
    HSPA5 -->|"associated with"| H3F3B
    DDIT3["DDIT3"]
    DDIT3 -->|"associated with"| H3F3B
    style H3F3B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
Hypertension	expressed_in	disease	0.65

Incoming (6)

Source	Relation	Type	Str
GADD45A	associated_with	gene	0.60
JUN	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
CEBPB	associated_with	gene	0.60
HSPA5	associated_with	gene	0.60
DDIT3	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning H3F3B in their description or question text

No additional research found