gene

IGF1R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF1R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

340Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

IGF1R is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with AD, ALS, Als. Connected to 173 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IGF1R
Chromosome	15q26.3
Protein Type	Receptor
Function	Ligand (IGF1 or IGF2) binding to extracellular α-subunits
Amino Acids	706 aa
Exons	21
Pathways	PI3K, MAPK
Ensembl ID	ENSG00000140443
GeneCards	IGF1R
Human Protein Atlas	IGF1R
Exon 1-2	5' UTR and signal peptide
Exons 3-11	α-subunit (extracellular ligand-binding domain)
Exons 12-21	β-subunit (transmembrane and intracellular domains)
Alternative splicing	Produces variants with tissue-specific expression
Associated Diseases	AD, Als, Alzheimer, Alzheimer's disease, Diabetes
Interactions	AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid-Beta
KG Connections	340 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IGF1R Gene

gene · 983 words

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Pathway Diagram

graph TD
    IGF1R["IGF1R"]
    IGF1R -->|"target for"| Als["Als"]
    IGF1R -->|"regulates"| Fibrosis["Fibrosis"]
    IGF1R -->|"regulates"| Inflammation["Inflammation"]
    IGF1R -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    IGF1R -->|"activates"| Alzheimer["Alzheimer"]
    IGF1R -->|"activates"| Ms["Ms"]
    IGF1R -->|"expressed in"| Cancer["Cancer"]
    IGF1R -->|"interacts"| Tumor["Tumor"]
    NINJURIN2["NINJURIN2"] -->|"interacts"| IGF1R
    HSPG2["HSPG2"] -->|"regulates"| IGF1R
    BDNF["BDNF"] -->|"activates"| IGF1R
    PDGFRB["PDGFRB"] -->|"activates"| IGF1R
    DAG1["DAG1"] -->|"regulates"| IGF1R
    BCL_2["BCL-2"] -->|"regulates"| IGF1R
    BAD["BAD"] -->|"regulates"| IGF1R
    IGF1["IGF1"] -->|"activates"| IGF1R
    PI3K["PI3K"] -->|"activates"| IGF1R
    AKT["AKT"] -->|"activates"| IGF1R

Outgoing (245)

Target	Relation	Type	Str
cancer	therapeutic_target	disease	0.92
ERK	activates	protein	0.90
MAPK	activates	pathway	0.90
transcriptional activation	regulates	process	0.88
neuropathic pain	therapeutic_target	disease	0.87
apoptosis	inhibits	process	0.87
Skin Fibrosis	drives	phenotype	0.80
Alzheimer's disease	implicated_in	disease	0.80
neuronal survival	regulates	biological_process	0.80
Aβ-induced inflammation	inhibits	phenotype	0.80
Aβ-induced neuronal death	inhibits	phenotype	0.80
Als	therapeutic_target	disease	0.75
Skin Fibrosis	involved_in	phenotype	0.70
oxidative stress response	participates_in	pathway	0.70
neurodegeneration	activates	disease	0.70
PIK3CA	interacts_with	gene	0.70
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Diabetes	associated_with	disease	0.65
Colorectal Cancer	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ms	activates	disease	0.65
Fibrosis	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Ms	inhibits	disease	0.65
Fibrosis	regulates	disease	0.65
Als	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Inflammation	interacts_with	disease	0.65
Diabetes	expressed_in	disease	0.65
Tumor	interacts_with	disease	0.65
Ms	expressed_in	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
PI3K_AKT	activates	pathway	0.64
NEURONAL_SURVIVAL	regulates	phenotype	0.64
EGR1	activates	protein	0.64
NEUROINFLAMMATION	regulates	phenotype	0.64
HSP90AA1	associated_with	gene	0.60
MAPK14	associated_with	gene	0.60
MDM2	associated_with	gene	0.60
RAF1	associated_with	gene	0.60
ESR1	associated_with	gene	0.60

Incoming (95)

Source	Relation	Type	Str
FST	binds_to	protein	0.95
Separating Microneedles	downregulates	compound	0.85
5-fluorouracil	downregulates	drug	0.80
NINJURIN2	interacts_with	protein	0.72
BAX	activates	gene	0.60
AKT1	interacts_with	gene	0.60
PI3K	inhibits	gene	0.60
TAU	therapeutic_target	gene	0.60
MAPK	associated_with	gene	0.60
IGF1	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
RAS	associated_with	gene	0.60
AND	expressed_in	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
RNA	regulates	gene	0.60
IL6	interacts_with	gene	0.60
PTGS2	interacts_with	gene	0.60
GSK3B	therapeutic_target	gene	0.60
ALZHEIMER	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
EXERCISE	activates	gene	0.60
INFLAMMATION	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
CYTOKINES	activates	gene	0.60
INS	therapeutic_target	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
ROS	regulates	gene	0.60
PDGF	activates	gene	0.60
NINJ2	activates	gene	0.60
BCL2L1	expressed_in	gene	0.60
MAP2K1	associated_with	gene	0.60
OVERVIEW	interacts_with	gene	0.60
PI3K	associated_with	gene	0.60
AKT	interacts_with	entity	0.60
EGR1	interacts_with	entity	0.60
APP	interacts_with	gene	0.60
CACNA1C	interacts_with	gene	0.60
AND	activates	gene	0.60
IGF1	expressed_in	gene	0.60
AMYLOID-BETA	activates	gene	0.60
IL-1	activates	gene	0.60
BDNF	activates	gene	0.60
EGR1	activates	gene	0.60
CDK5	therapeutic_target	gene	0.60
CACNA1C	therapeutic_target	gene	0.60
MMP2	therapeutic_target	gene	0.60
ESR1	therapeutic_target	gene	0.60
CS	associated_with	gene	0.60
MYOD	inhibits	gene	0.60
IL-10	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IGF1R in their description or question text

No additional research found