gene

TRPM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

135Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for TRPM2 - Transient Receptor Potential Melastatin 2

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	TRPM2
Full Name	Transient Receptor Potential Cation Channel Subfamily M Member 2
Aliases	Page for TRPM2, Page for TRPM2 Protein, Transient Receptor Potential Melastatin 2
Chromosome	21q22.12
Protein Type	Channel
Function	is a calcium-permeable cation channel activated by oxidative stress and ADP-ribose.
Molecular Weight	203 kDa
Amino Acids	1705 aa
Pathways	Oxidative Stress
UniProt ID	TRPM2
Ensembl ID	ENSG00000086848
GeneCards	TRPM2
Human Protein Atlas	TRPM2
N-terminal MHR domains	Four melastatin homology regions mediate tetramerization
Transmembrane domain	Six transmembrane helices (S1-S6) forming the pore
Associated Diseases	Als, Bipolar, Bipolar Disorder, BIPOLAR_DISORDER, Depression
Interactions	AMPK, AND, APOPTOSIS, ATG5, BECN1, CAMK2
KG Connections	135 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TRPM2["TRPM2"] -->|"associated"| Schizophrenia["Schizophrenia"]
    TRPM2["TRPM2"] -->|"associated"| Als["Als"]
    TRPM2["TRPM2"] -->|"associated"| Depression["Depression"]
    TRPM2["TRPM2"] -->|"associated"| Bipolar["Bipolar"]
    TRPM2["TRPM2"] -->|"associated"| Ms["Ms"]
    TRPM2["TRPM2"] -->|"activates"| Ms_1["Ms"]
    HTR2A["HTR2A"] -->|"associated"| TRPM2["TRPM2"]
    DISC1["DISC1"] -->|"associated"| TRPM2["TRPM2"]
    FKBP5["FKBP5"] -->|"associated"| TRPM2["TRPM2"]
    NRG1["NRG1"] -->|"associated"| TRPM2["TRPM2"]
    style TRPM2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (68)

Target	Relation	Type	Str
Bipolar Disorder	associated_with	disease	0.80
MTOR	inhibits	pathway	0.80
oxidative stress response	participates_in	pathway	0.70
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Schizophrenia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Ms	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Ischemia	regulates	disease	0.65
GENES	associated_with	gene	0.60
PDLIM5	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
DNA	associated_with	gene	0.60
Oxidative Stress	regulates	pathway	0.60
HTR2A	associated_with	gene	0.60
ULK1	activates	gene	0.60
TRPM3	implicated_in	gene	0.60
App	associated_with	protein	0.60
TLR4	activates	gene	0.60
GRM4	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
synaptic plasticity	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
DRD1	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
DAO	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
RGS4	associated_with	gene	0.60
NCAM1	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
POLG	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
SYNGR1	associated_with	gene	0.60
TPH2	associated_with	gene	0.60
Angiogenesis	activates	pathway	0.60
Notch	activates	pathway	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
Nf-Κb	activates	pathway	0.60
Bdnf	associated_with	protein	0.60
GRM3	associated_with	gene	0.60
Notch signaling	participates_in	pathway	0.60
ferroptosis	participates_in	pathway	0.60
neurodegeneration	protects_against	disease	0.60

Incoming (67)

Source	Relation	Type	Str
ROS	activates	gene	0.70
HTR2A	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
DAO	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
GRM4	associated_with	gene	0.60
SYNGR1	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
NCAM1	associated_with	gene	0.60
RGS4	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
TPH2	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
POLG	associated_with	gene	0.60
RELA	activates	gene	0.60
ATG5	activates	gene	0.60
BECN1	activates	gene	0.60
CAMK2	activates	gene	0.60
CASP3	activates	gene	0.60
DMPK	activates	gene	0.60
GFAP	activates	gene	0.60
HIF1A	activates	gene	0.60
HMGCR	activates	gene	0.60
LAMP1	activates	gene	0.60
LC3	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
PIK3C3	activates	gene	0.60
PLP1	activates	gene	0.60
PRKDC	activates	gene	0.60
SLC17A6	activates	gene	0.60
SQSTM1	activates	gene	0.60
GENES	associated_with	gene	0.60
NOTCH1	expressed_in	gene	0.60
TNF	activates	gene	0.60
TNF	inhibits	gene	0.60
MTDNA	associated_with	gene	0.60
DNA	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
IGF2BP2	interacts_with	gene	0.60
NOTCH1	activates	gene	0.60
HTTLPR	associated_with	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
PERIOD3	associated_with	gene	0.60
G72	associated_with	gene	0.60
CANCER	activates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRPM2 in their description or question text

No additional research found