protein

HTR2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

155Connections
1Hypotheses
1Analyses
50Outgoing
50Incoming
0Experiments
1Debates

Summary

HTR2A is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with ALS, Als, Bipolar. Connected to 60 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolHTR2A
Full Name5-Hydroxytryptamine Receptor 2A
Chromosome13q14.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionCortex, Platelets, Smooth muscle, Olfactory bulb
Molecular Weight60 kDa
UniProt IDP28223
NCBI Gene ID3352
Ensembl IDENSG00000102468
GeneCardsHTR2A
Human Protein AtlasHTR2A
Associated DiseasesAls, Alzheimer, Autism, Bipolar, Cancer
InteractionsCACNA1B, CACNA1H, DRD1, DRD2, GABRA1, GABRB2
KG Connections155 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: HTR2A — AlphaFold P28223 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HTR2A Gene

gene · 1361 words

Pathway Diagram

graph TD
    HTR2A["HTR2A"]
    Schizophrenia{"Schizophrenia"}
    HTR2A -->|"associated with"| Schizophrenia
    Als{"Als"}
    HTR2A -->|"associated with"| Als
    Depression{"Depression"}
    HTR2A -->|"associated with"| Depression
    Bipolar{"Bipolar"}
    HTR2A -->|"associated with"| Bipolar
    Ms{"Ms"}
    HTR2A -->|"associated with"| Ms
    ALS{"ALS"}
    HTR2A -->|"associated with"| ALS
    DISC1["DISC1"]
    HTR2A -->|"associated with"| DISC1
    FKBP5["FKBP5"]
    HTR2A -->|"associated with"| FKBP5
    NRG1["NRG1"]
    HTR2A -->|"associated with"| NRG1
    DAO["DAO"]
    HTR2A -->|"associated with"| DAO
    BMAL1["BMAL1"]
    HTR2A -->|"associated with"| BMAL1
    GRM4["GRM4"]
    HTR2A -->|"associated with"| GRM4
    HTTLPR["HTTLPR"]
    HTTLPR -->|"associated with"| HTR2A
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    MITOCHONDRIAL_DNA -->|"associated with"| HTR2A
    BDNF["BDNF"]
    BDNF -->|"associated with"| HTR2A
    PERIOD3["PERIOD3"]
    PERIOD3 -->|"associated with"| HTR2A
    BMAL1 -->|"associated with"| HTR2A
    NCAM1["NCAM1"]
    NCAM1 -->|"associated with"| HTR2A
    DISC1 -->|"associated with"| HTR2A
    G72["G72"]
    G72 -->|"associated with"| HTR2A
    NRG1 -->|"associated with"| HTR2A
    MTDNA["MTDNA"]
    MTDNA -->|"associated with"| HTR2A
    DAO -->|"associated with"| HTR2A
    TRPM2["TRPM2"]
    TRPM2 -->|"associated with"| HTR2A
    style HTR2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (83)

TargetRelationTypeStr
benchmark_ot_ad_answer_key:HTR2Adata_indataset_row0.00
ds-83b31ef18d49provides_data_fordataset1.00
ds-db4a006ea647provides_data_fordataset1.00
NOTCHtransportsgene0.70
SLC6A4transportsgene0.70

Incoming (72)

SourceRelationTypeStr
H4antagonizeshypothesis0.00
benchmark_ot_ad_answer_key:HTR2Adata_indataset_row0.00
ds-db4a006ea647data_indataset1.00
ds-83b31ef18d49data_indataset1.00
CHRNA7regulatesgene0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
HTR2A-Mediated MMP-9 Suppression Preserves BBB Integrity at 0.425 - What is the minimum effective dose of tr

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the minimum effective dose of trazodone required for disease-modifying e

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.605

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What is the minimum effective dose of trazodone required for disease-modifying e

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning HTR2A in their description or question text

No additional research found