concept

RA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

158Connections

30Hypotheses

5Analyses

0Outgoing

50Incoming

11Experiments

6Debates

Summary

RA is a concept in neurodegeneration research. Key relationships include: implicated in, associated with. Connected to 158 entities in the SciDEX knowledge graph.

View on Wiki →

AI-generated illustration · click image to enlarge

Regenerate portrait ↻

💡 Concept Info

Name	RA
Key Genes/Proteins	A2M, ABCA1, ABCB1, ABCG1, ACTB, AGER
Linked Hypotheses	19 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    RA["RA"]
    MAP1B["MAP1B"] -->|"implicated in"| RA
    MAP2["MAP2"] -->|"implicated in"| RA
    MAP6["MAP6"] -->|"implicated in"| RA
    GLUT4["GLUT4"] -->|"implicated in"| RA
    PPAR["PPAR"] -->|"implicated in"| RA
    RAB7A["RAB7A"] -->|"implicated in"| RA
    LRP2["LRP2"] -->|"implicated in"| RA
    ACTB["ACTB"] -->|"implicated in"| RA
    CTSD["CTSD"] -->|"implicated in"| RA
    ATG["ATG"] -->|"implicated in"| RA

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (158)

Source	Relation	Type	Str
RBP	associated_with	protein	0.56
TIGAR	implicated_in	gene	0.50
IGF1R	implicated_in	gene	0.50
TKT	implicated_in	gene	0.50
CIC	implicated_in	gene	0.50
NAD	implicated_in	gene	0.50
LC3	implicated_in	gene	0.50
BRAF	implicated_in	gene	0.50
H3F3A	implicated_in	gene	0.50
ATRX	implicated_in	gene	0.50
ABCA1	implicated_in	gene	0.50
MCU	implicated_in	gene	0.50
LETM1	implicated_in	gene	0.50
P2RY12	implicated_in	gene	0.50
FUBP1	implicated_in	gene	0.50
APOA1	implicated_in	gene	0.50
PI3K	implicated_in	gene	0.50
MAP1LC3	implicated_in	gene	0.50
ABCG1	implicated_in	gene	0.50
LOX	implicated_in	gene	0.50
AMPK	implicated_in	gene	0.50
AKT	implicated_in	gene	0.50
TNF	implicated_in	gene	0.50
ULK1	implicated_in	gene	0.50
LDL	implicated_in	gene	0.50
ATG5	implicated_in	gene	0.50
IBA1	implicated_in	gene	0.50
REL	implicated_in	gene	0.50
CERS2	implicated_in	gene	0.50
DAG1	implicated_in	gene	0.50
HIF	implicated_in	gene	0.50
HSPG2	implicated_in	gene	0.50
BAD	implicated_in	gene	0.50
DAPK1	implicated_in	gene	0.50
PARP1	implicated_in	gene	0.50
A2M	implicated_in	gene	0.50
DHCR24	implicated_in	gene	0.50
HMGCR	implicated_in	gene	0.50
IL6	implicated_in	gene	0.50
PSEN1	implicated_in	gene	0.50
APH1B	implicated_in	gene	0.50
APP	implicated_in	gene	0.50
PEN2	implicated_in	gene	0.50
MAPT	implicated_in	gene	0.50
FAS	implicated_in	gene	0.50
IL1B	implicated_in	gene	0.50
IDH1	implicated_in	gene	0.50
PSEN2	implicated_in	gene	0.50
EIF2AK2	implicated_in	gene	0.50
IDH2	implicated_in	gene	0.50

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound targeting EC-II	0.968	Alzheimer's disease	Circuit-level neural dynamics in neurode
GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Cl	0.964	neuroscience	Circuit-level neural dynamics in neurode
Plasma NfL Elevation Secondary to BBB-Associated Transport D	0.940	-	What blood-brain barrier permeability ch
Gamma entrainment therapy to restore hippocampal-cortical sy	0.920	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.912	Alzheimer's disease	Circuit-level neural dynamics in neurode

Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming	0.907	neurodegeneration	What are the mechanisms by which gut mic
eIF2α Phosphorylation Imbalance Creates Integrated Stress Re	0.896	ALS	-
TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegener	0.892	neurodegeneration	Gene expression changes in aging mouse b
Optimized Temporal Window for Metabolic Boosting Therapy Det	0.887	neurodegeneration	How do different microglial subtypes (DA
TBK1 Loss Locks Microglia in an Aged/Senescent Transcription	0.878	ALS	What are the mechanisms by which microgl
APOE-Dependent Autophagy Restoration	0.877	neurodegeneration	Survival Analysis of AD Patient Cohorts:
RBM45 Liquid-Liquid Phase Separation Dominance Hijacks RNA P	0.868	ALS	-
Optogenetic restoration of hippocampal gamma oscillations vi	0.865	Alzheimer's disease	Circuit-level neural dynamics in neurode
Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated	0.865	molecular neurobiology	View
Glymphatic-Mediated Tau Clearance Dysfunction	0.865	neuroscience	Proteomics Differential Expression in AD
Activity-Dependent CD55/CD46 Trafficking and Synaptic Surfac	0.000	synaptic biology	What determines the selectivity of compl
Alpha-theta entrainment therapy to enhance default mode netw	0.000	Alzheimer's disease	Circuit-level neural dynamics in neurode
TBK1 Loss Triggers Astrocyte-to-Neuron Senescence Propagatio	0.000	ALS	What are the mechanisms by which microgl
LDLR-Mediated Neurosteroid Precursor Delivery Strategy	0.000	neuropharmacology	What is the actual quantitative contribu
CYP46A1 Small Molecule Activator Therapy	0.000	neurodegeneration	Lipid raft composition changes in synapt
H6-V1: Aberrant eIF2α Phosphorylation Drives Mitochondrial T	0.000	neurodegeneration	How do pathological stress granules tran
LAMP2A Upregulation to Enhance Chaperone-Mediated Autophagy	0.000	proteomics	Quantitative proteomics of the aging syn
CREB-Dependent Differential Complement Regulator Positioning	0.000	synaptic biology	What determines the selectivity of compl
TBK1 Loss Triggers eIF2α-Mediated Translational Repression T	0.000	ALS	What are the mechanisms by which microgl
CYP46A1-Mediated Cholesterol Reduction Prevents eIF2α-Driven	0.000	neurodegeneration	Lipid raft composition changes in synapt
Closed-loop transcranial focused ultrasound to restore hippo	0.000	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound with gamma entra	0.000	Alzheimer's disease	Circuit-level neural dynamics in neurode
GLUT1-Mediated Carrier-Conjugate Delivery Strategy	0.000	neuropharmacology	What is the actual quantitative contribu
LDLR-Primed LRP1 Transcytosis with pH-Responsive Escape Stra	0.000	neuropharmacology	What is the actual quantitative contribu
J-protein substrate specificity codes enable HSP70 discrimin	0.000	protein biochemistry	Do chaperones selectively recognize path

Mentioning Analyses (5)

Scientific analyses that reference this entity

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

neuropharmacology | 2026-04-25 | 4 hypotheses Top: 0.659

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

neurodegeneration | 2026-04-24 | 5 hypotheses Top: 0.790

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

neurodegeneration | 2026-04-23 | 7 hypotheses Top: 0.780

What amyloid threshold level is required for optimal clinical benefit in early A

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.577

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

neurodegeneration | 2026-04-14 | 0 hypotheses

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Plant-based dietary patterns and Alzheimer's disease risk in multiethn	clinical	Alzheimer's disease and relate	0.950	0.00	human patients	proposed	N/A
Tet2 modulation in Aβ42-injured mouse hippocampal neurons	exploratory	Alzheimer's disease	0.900	0.00	primary mouse hippocampal neur	proposed	N/A
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$180,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis	clinical	Alzheimer's Disease	0.400	0.50	human	completed	$6,550,000
Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Res	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Anatomical and neurochemical profiles of somatostatin-positive neurons in the mo [PMID:41796787]	Tomioka R, Kobayashi K, Song WJ	Neuroscience	2026	0
Subtype-Specific Roles of Anterior Cingulate Cortex Neurons in Pain-Induced Soci [PMID:41799202]	Wan X, Yan Z, Zhang Z, Liu X, Yang D, Zh	Theranostics	2026	0
A comparative analysis of pig-to-rhesus corneal xenotransplantation with various [PMID:41928466]	Lee SH, Yoon CH, Choi HJ, Lee HJ, Kang H	Korean J Ophthalmol	2026	0
Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestat [PMID:41779871]	Zhu H, Luo S, Liu C, Cheng Y, Ren Z, Mo	Science translational medicine	2026	0
Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: [PMID:41854733]	Liu K, Zhang XY, Wang YT, Wang R, Jin RH	Molecular neurobiology	2026	0
Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138]	Singer Y, Yitzhaky A, Hertzberg L	Alpha psychiatry	2026	0
Paracrine inhibition via G protein inwardly rectifying potassium channels regula [PMID:41824458]	Panzer JK, Lang AL, Levi NJ, Garcia PA,	Cell reports	2026	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
GADD45G operates as a pathological sensor orchestrating reactive gliosis and neu [PMID:40409253]	Shen T, Tai W, Jiang D, Ma S, Zhong X, Z	Neuron	2025	0
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheime [PMID:41035073]	Castanho I, Naderi Yeganeh P, Boix CA, M	Molecular neurodegeneration	2025	0
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974]	Dai L, Wang J, Meng L, Zhang X, Xiao T,	PLoS biology	2025	0
Molecular hallmarks of excitatory and inhibitory neuronal resilience and resista [PMID:39868232]	Castanho I, Yeganeh PN, Boix CA, Morgan	bioRxiv : the preprint server	2025	0
From stress to Alzheimer's: A circuit-based framework for prefrontal cognitive d [PMID:41115499]	Yi JH	Neuroscience letters	2025	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Hippocampal Interneurons Shape Spatial Coding Alterations in Neurological Disord [PMID:40392508]	Ikebara JM, Jorge RS, Marinho LSR, Higa	Molecular neurobiology	2025	0
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing Res Rev	2024	0
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667]	Zhang D, Zhang W, Ming C, Gao X, Yuan H,	Neuron	2024	0
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117]	Balusu S, De Strooper B	Acta neuropathologica	2024	0

Debates (6)

Multi-agent debates referencing this entity

The debate highlighted that G2019S shows elevated baseline RAB10 phosphorylation

closed · Rounds: 4 · Score: 0.80 · 2026-04-26

Hypothesis debate: Multi-Biomarker Composite Index Surpassing Amyloid PET for Tr

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

closed · Rounds: 4 · Score: 0.66 · 2026-04-25

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

closed · Rounds: 4 · Score: 0.74 · 2026-04-24

While the study demonstrates dose-response relationships between amyloid levels

closed · Rounds: 4 · Score: 0.76 · 2026-04-16

The study demonstrates significant reduction in dementia risk (HR 0.63) with GLP

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning RA in their description or question text

Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration

Score: 0.907 · neurodegeneration · 2026-04-05

## Mechanistic Overview Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration starts from the

TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration

Score: 0.892 · neurodegeneration · 2026-04-07

## Mechanistic Overview TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration starts from the claim that mod

Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of M

Score: 0.887 · neurodegeneration · 2026-04-16

## Mechanistic Overview Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of Microglial State

TBK1 Loss Locks Microglia in an Aged/Senescent Transcriptional State, Fueling AL

Score: 0.878 · ALS · 2026-04-26

The hypothesis proposes that loss-of-function mutations in TBK1 contribute to ALS pathogenesis by trapping microglia in

APOE-Dependent Autophagy Restoration

Score: 0.877 · neurodegeneration · 2026-04-02

## Mechanistic Overview APOE-Dependent Autophagy Restoration starts from the claim that modulating MTOR within the disea

Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

Score: 0.865 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Optogenetic restoration of hippocampal gamma oscillations via selective PV interneuron activatio

Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV

Score: 0.865 · molecular neurobiology · 2026-04-17

## Mechanistic Overview Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV Interneuron-Spe

Glymphatic-Mediated Tau Clearance Dysfunction

Score: 0.865 · neuroscience · 2026-04-07

## Mechanistic Overview Glymphatic-Mediated Tau Clearance Dysfunction starts from the claim that modulating MAPT within

Activity-Dependent CD55/CD46 Trafficking and Synaptic Surface Localization

Score: 0.000 · synaptic biology · 2026-04-28

The activity-dependent trafficking of complement regulators CD55 and CD46 to synaptic surfaces represents a dynamic regu

Alpha-theta entrainment therapy to enhance default mode network coherence

Score: 0.000 · Alzheimer's disease · 2026-04-28

Alpha-theta entrainment therapy targets somatostatin (SST) interneurons to restore default mode network (DMN) coherence

TBK1 Loss Triggers Astrocyte-to-Neuron Senescence Propagation Through SASP-Media

Score: 0.000 · ALS · 2026-04-28

This hypothesis proposes that TBK1 loss-of-function mutations drive ALS pathogenesis by inducing senescence in astrocyte

LDLR-Mediated Neurosteroid Precursor Delivery Strategy

Score: 0.000 · neuropharmacology · 2026-04-28

The LDLR-Mediated Neurosteroid Precursor Delivery Strategy proposes utilizing the low-density lipoprotein receptor (LDLR

CYP46A1 Small Molecule Activator Therapy

Score: 0.000 · neurodegeneration · 2026-04-28

This approach employs pharmacological activation of endogenous CYP46A1 rather than gene overexpression to treat Alzheime

RA

Understanding Entity Pages

Summary

Wiki Pages (20)

TRA2B Protein - Transformer-2 Beta

RASGRP1 Gene

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

RAB9A

RRAS3 — Related RAS Virus (R-Ras) Family Member 3

IL1RAP — Interleukin-1 receptor accessory protein

RAD21 — Cohesin Complex Component in Neurodegeneration

RASGRF1 — Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1

RAN Translation in Neurodegeneration

RRAGB — Ras-Related GTP Binding B

RAB4B Gene

RAB35 — Ras-Associated Protein 35

RAB43 Gene

PILRA Gene

TRAIL Gene (TNFSF10)

RAB39B Endosomal-Lysosomal Dysfunction PD Causal Chain

RRAS2 — Related RAS Virus (R-Ras) Family Member 2

RAB2A Gene

RABEP1

RAC1 Gene

Pathway Diagram

Outgoing (0)

Incoming (158)

Targeting Hypotheses (30)

Mentioning Analyses (5)

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

What amyloid threshold level is required for optimal clinical benefit in early A

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

Experiments (11)

Related Papers (20)

Debates (6)

The debate highlighted that G2019S shows elevated baseline RAB10 phosphorylation

Hypothesis debate: Multi-Biomarker Composite Index Surpassing Amyloid PET for Tr

How does parthenolide specifically modulate ADORA2A signaling to produce antidep

Do pathogenic LRRK2 mutations amplify volume-sensing signals or just elevate bas

While the study demonstrates dose-response relationships between amyloid levels

The study demonstrates significant reduction in dementia risk (HR 0.63) with GLP

Related Research

Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration

TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration

Optimized Temporal Window for Metabolic Boosting Therapy Determines Success of M

TBK1 Loss Locks Microglia in an Aged/Senescent Transcriptional State, Fueling AL

APOE-Dependent Autophagy Restoration

Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV

Glymphatic-Mediated Tau Clearance Dysfunction

Activity-Dependent CD55/CD46 Trafficking and Synaptic Surface Localization

Alpha-theta entrainment therapy to enhance default mode network coherence

TBK1 Loss Triggers Astrocyte-to-Neuron Senescence Propagation Through SASP-Media

LDLR-Mediated Neurosteroid Precursor Delivery Strategy

CYP46A1 Small Molecule Activator Therapy