gene

MCL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MCL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

350Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MCL1 (Myeloid Cell Leukemia 1) is an anti-apoptotic BCL2 family protein critical for neuronal survival, mitochondrial integrity, and regulation of apoptosis in neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	MCL1
Full Name	Myeloid Cell Leukemia 1
Chromosome	1q21.2
Function	encodes a critical anti-apoptotic protein of the BCL2 family that plays essential roles in regulating mitochondrial outer membrane permeabilization (MOMP), cellular survival, and mitochondrial dyna...
Molecular Weight	37 kDa
Amino Acids	350 aa
Pathways	NF-κB
UniProt ID	[Q07820](https://www.uniprot.org/uniprot/Q07820)
Ensembl ID	ENSG00000143384
GeneCards	MCL1
Human Protein Atlas	MCL1
Associated Diseases	AD, ALI, Als, Alzheimer, AMI
Interactions	ACHE, AD, AND, APOB, APOE, APOPTOSIS
KG Connections	350 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MCL1 Gene - Myeloid Cell Leukemia 1

gene · 2173 words

→

MCL1 Protein

protein · 705 words

→

Pathway Diagram

graph TD
    MCL1["MCL1
Anti-apoptotic BCL2 Family"] -->|"inhibits"| Apoptosis["Apoptosis"]
    MCL1 -->|"interacts with"| BOK["BOK"]
    MCL1 -->|"expressed in"| BCL2["BCL2"]
    MCL1 -->|"expressed in"| BCL2L1["BCL2L1/BCL-XL"]
    MCL1 -->|"regulates"| APP["APP"]
    MCL1 -->|"therapeutic target"| BAX["BAX"]
    MCL1 -->|"inhibits"| Angiogenesis["Angiogenesis"]

    BCL2 -->|"regulates"| MCL1
    APP -->|"regulates"| MCL1
    CTSD["CTSD"] -->|"inhibits"| MCL1

    MCL1 -->|"implicated in"| AD["Alzheimer's Disease"]
    MCL1 -->|"implicated in"| ALS["ALS"]
    MCL1 -->|"associated with"| Cancer["Cancer"]
    MCL1 -->|"implicated in"| HCC["Hepatocellular Carcinoma"]

    style MCL1 fill:#e74c3c,stroke:#c0392b,color:#e0e0e0
    style Apoptosis fill:#f39c12,stroke:#e67e22,color:#e0e0e0
    style AD fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0
    style ALS fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0
    style Cancer fill:#9b59b6,stroke:#8e44ad,color:#e0e0e0

Outgoing (202)

Target	Relation	Type	Str
Cell Survival	promotes	process	0.88
BCL2	coexpressed_with	protein	0.87
cell survival	promotes	process	0.85
Tumor Cell	expressed_in	cell_type	0.85
Cancer	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
Cancer	expressed_in	disease	0.75
Tumor Cells	expressed_in	cell_type	0.75
Als	therapeutic_target	disease	0.75
BCL2	expressed_in	gene	0.70
CANCER	expressed_in	gene	0.70
Tumor	expressed_in	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Lymphoma	activates	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Lymphoma	regulates	disease	0.65
ALS	inhibits	disease	0.65
Leukemia	regulates	disease	0.65
Glioblastoma	activates	disease	0.65
Als	causes	disease	0.65
Aging	therapeutic_target	disease	0.65
Lymphoma	associated_with	disease	0.65
ALS	regulates	disease	0.65
Colorectal Cancer	expressed_in	disease	0.65
Tumor	regulates	disease	0.65
Carcinoma	inhibits	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Leukemia	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Leukemia	therapeutic_target	disease	0.65
BAX	therapeutic_target	gene	0.60
BOK	interacts_with	gene	0.60
PD	activates	gene	0.60
MET	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
PARKINSON DISEASE	inhibits	disease	0.60
oxidative stress response	participates_in	pathway	0.60
BCL2L1	expressed_in	gene	0.60
MYC	regulates	gene	0.60
STAT3	expressed_in	gene	0.60

Incoming (148)

Source	Relation	Type	Str
Sy-1365	downregulates	drug	0.85
TP53	regulates	gene	0.80
AGGF1	upregulates	gene	0.70
BOK	interacts_with	protein	0.70
AD	inhibits	gene	0.60
APOE	inhibits	gene	0.60
CSF1R	regulates	gene	0.60
ACHE	inhibits	gene	0.60
GSK3B	causes	gene	0.60
APOPTOSIS	co_discussed	pathway	0.60
AUTOPHAGY	co_discussed	pathway	0.60
BECN1	co_discussed	gene	0.60
MAPK	co_discussed	gene	0.60
APOPTOSIS	interacts_with	pathway	0.60
EEF1A1	associated_with	gene	0.60
GBA	regulates	gene	0.60
CTSD	inhibits	gene	0.60
CD47	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
MDM4	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
SF3B1	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
EEF1A1	therapeutic_target	gene	0.60
APP	regulates	gene	0.60
PARKIN	interacts_with	gene	0.60
APOPTOSIS	regulates	pathway	0.60
BCL2	inhibits	gene	0.60
BCL2	regulates	gene	0.60
APOB	associated_with	gene	0.60
AUTOPHAGY	interacts_with	pathway	0.60
BCL2L1	expressed_in	gene	0.60
AUTOPHAGY	inhibits	pathway	0.60
CD33	therapeutic_target	gene	0.60
BAX	therapeutic_target	gene	0.60
MYC	associated_with	gene	0.60
UBIQUITIN	inhibits	gene	0.60
CASP8	interacts_with	gene	0.60
MMP2	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
GBM	interacts_with	gene	0.60
CDK4	interacts_with	gene	0.60
TLR4	regulates	gene	0.60
PI3K	regulates	gene	0.60
TNF	regulates	gene	0.60
MACROPHAGE	regulates	cell_type	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MCL1 in their description or question text

No additional research found