| Gene Symbol | RRAGB |
| Full Name | Ras-Related GTP Binding B |
| Chromosome | Xq12 |
| Function | encodes a member of the Rag GTPase family that plays a critical role in amino acid sensing and the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway. |
| Amino Acids | 313 aa |
| Pathways | mTOR, mtor |
| UniProt ID | Q9NQQ5 |
| NCBI Gene ID | 10671 |
| Ensembl ID | ENSG00000147434 |
| GeneCards | RRAGB |
| Human Protein Atlas | RRAGB |
| N-terminal domain | GTP/GDP binding domain with Switch I and Switch II regions that undergo conformational changes between active (GTP-bound) and inactive (GDP-bound) states |
| GTPase domain | Catalyzes GTP hydrolysis, regulated by GAPs (GTPase-activating proteins) and GEFs (guanine nucleotide exchange factors) |
| C-terminal region | Involved in heterodimer formation with RRAGA |
| Guanine nucleotide exchange | The Ragulator complex, anchored to the lysosomal membrane, acts as a GEF for RagA/B, promoting the GTP-bound (active) state in response to amino acid presence. |
| Associated Diseases | Neurodegeneration, X-linked Intellectual Disability, Parkinson's Disease |
| Interactions | ATF4, ATG, ATG8, AUTOPHAGY, CANCER, EIF2A |
| KG Connections | 49 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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