gene

AGER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AGER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

148Connections

1Hypotheses

1Analyses

50Outgoing

11Incoming

1Experiments

1Debates

Summary

A gene referenced in 143 knowledge graph relationships. Key connections: mediates Microglia Activation (process); activates Microglial Activation (process); activates Microglia Activation (process).

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	AGER
Full Name	RAGE
Chromosome	6p21.3
Protein Type	Receptor
Target Class	Protein
Function	RAGE is a multi-ligand receptor that binds: - Advanced glycation end products (AGEs) - HMGB1 (High Mobility Group Box 1) - S100B protein - Amyloid-beta fibrils - DNA release from damaged cells
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade
Druggability	Undruggable (0.23)
Pathways	NF-κB, MAPK
UniProt ID	Q15120
NCBI Gene ID	177
OMIM	600841
GeneCards	AGER
Human Protein Atlas	AGER
Associated Diseases	AD, ALI, als, Alzheimer's disease
Known Drugs/Compounds	CHEMBL2179074, CHEMBL2205553, CHEMBL2205552, CHEMBL2205550, CHEMBL2205549, CHEMBL2205572
Interactions	EGFR, HER2, HLA, HSPA1A, HSPA1B, NCOA4
SciDEX Target	View Target Profile
SciDEX Hypotheses	Blocking AGE-RAGE Signaling in Enteric Glia to Pre
KG Connections	144 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

AGER Gene

gene · 725 words

→

AGER/RAGE Protein

protein · 2601 words

→

Pathway Diagram

flowchart TD
    A["AGER"] --> B["RAGE Signaling"]
    A --> C["AGE Ligand Binding"]
    C --> B
    B --> D["NF-kB Activation"]
    D --> E["Pro-inflammatory Cytokines"]
    B --> F["Oxidative Stress"]
    E --> G["Chronic Neuroinflammation"]
    F --> G
    G --> H["Blood-Brain Barrier Dysfunction"]
    G --> I["Neuronal Apoptosis"]
    I --> J["Cognitive Decline"]

Outgoing (137)

Target	Relation	Type	Str
Microglial Activation	activates	process	0.90
Microglia Activation	mediates	process	0.90
Microglia Activation	activates	process	0.89
Alzheimer's Disease	involved_in	disease	0.85
Inflammation	promotes	process	0.85
Alzheimer'S Disease	involved_in	disease	0.85
Blood-Brain Barrier	involved_in	process	0.80
Inflammatory Response	activates	process	0.80
APP	binds	protein	0.80
MICROVASCULAR_COMPLICATIONS	associated_with	phenotype	0.72
ALS	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Als	associated_with	disease	0.65
HSPA1A	associated_with	gene	0.60
spinal cord	expressed_in	brain_region	0.60
RAGE	expressed_in	gene	0.60
HLA	interacts_with	gene	0.60
HSPA1B	associated_with	gene	0.60
HLA	associated_with	gene	0.60
ALS	protects_against	gene	0.60
TLR4	associated_with	gene	0.60
NCOA4	inhibits	gene	0.60
SOD1G93A	expressed_in	gene	0.60
SOD1G93A	protects_against	gene	0.60
ALS	expressed_in	gene	0.60
neural stem cells	expressed_in	cell_type	0.60
lipid metabolism	participates_in	pathway	0.60
microglia	expressed_in	cell_type	0.60
microglia	protects_against	cell_type	0.60
NF-kB signaling	participates_in	pathway	0.60
HSPA1A	interacts_with	gene	0.60
HSPA1B	interacts_with	gene	0.60
RAGE	regulates	gene	0.55
lung cancer	interacts_with	disease	0.50
SOD1G93A	associated_with	gene	0.50
neuron	regulates	cell_type	0.50
EGFR	activates	gene	0.50
T cell	activates	cell_type	0.50
SOD1G93A	regulates	gene	0.50
GR	associated_with	gene	0.50
type 2 diabetes	implicated_in	disease	0.50
metabolic diseases	implicated_in	disease	0.50
RAGE	associated_with	gene	0.50
GLO1	associated_with	gene	0.50
CD33	therapeutic_target	gene	0.50
DLL3	therapeutic_target	gene	0.50
AD	implicated_in	disease	0.50
ALI	implicated_in	disease	0.50

Incoming (11)

Source	Relation	Type	Str
h-8f285020	targets_gene	hypothesis	0.90
HSPA1A	associated_with	gene	0.60
HSPA1B	associated_with	gene	0.60
h-8f285020	targets	hypothesis	0.50
TIA1L Protein	references	protein	0.40
TDC	co_discussed	gene	0.40
TLR4	co_discussed	gene	0.40
DDC	co_discussed	gene	0.40
GPR109A	co_discussed	gene	0.40
CHRNA7	co_discussed	gene	0.40
HDAC	co_discussed	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro	0.613	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.907

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
AGE-mediated HCC induction in animal models with β-catenin signaling	validation	Hepatocellular carcinoma	0.900	0.00	animal models (species not spe	proposed	N/A

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Decoding cell death signals in liver inflammation. [PMID:23567086]	Brenner C, Galluzzi L, Kepp O, Kroemer G	J Hepatol	2013	1
Wnt-dependent modulation of alveolar epithelial phenotypes and barrier function [PMID:41678947]	Lin YC, Igarashi M, Sakai Y, Nishikawa M	Biochem Biophys Res Commun	2026	0
Luteolin targets the AGE-RAGE signaling to mitigate inflammation and ferroptosis [PMID:38917486]	Zhang N, Chen P, Liang X, Sun J, Liu Q,	Aging	2024	0
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic li [PMID:38297127]	Fan W, Adebowale K, Váncza L, Li Y, Rabb	Nature	2024	0
Receptors for Advanced Glycation End Products (RAGE): Promising Targets Aiming a [PMID:36154605]	["Koerich S", "Parreira G", "de Almeida	Current neuropharmacology	2023	0
Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE/EGFR [PMID:37442582]	Strickson S, Houslay KF, Negri VA, Ohne	The European respiratory journ	2023	0
Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1 [PMID:34130712]	["MacLean M", "Juranek J", "Cuddapah S",	Journal of neuroinflammation	2021	0
Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425]	Lieberwirth JK, Joset P, Heinze A, Hents	European journal of human gene	2021	0
Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174]	Liu J, Xie J	International journal of envir	2020	0
Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582]	Karas M, Marinsek N, Goldhahn J, Foschin	Digital biomarkers	2020	0
Glycation & the RAGE axis: targeting signal transduction through DIAPH1. [PMID:27967251]	["Shekhtman A", "Ramasamy R", "Schmidt A	Expert review of proteomics	2017	0
The AGE-RAGE Axis: Implications for Age-Associated Arterial Diseases. [PMID:29259621]	["Senatus L", "Schmidt A"]	Frontiers in genetics	2017	0
Diabetes and Alzheimer's disease crosstalk. [PMID:26969101]	Baglietto-Vargas D, Shi J, Yaeger DM, Ag	Neuroscience and biobehavioral	2016	0
Pathophysiological Links Among Hypertension and Alzheimer's Disease. [PMID:26054481]	Carnevale D, Perrotta M, Lembo G, Trimar	High blood pressure & cardiova	2016	0
High-fructose intake as risk factor for neurodegeneration: Key role for carboxy [PMID:26851500]	["Mastrocola R", "Nigro D", "Cento A", "	Neurobiology of disease	2016	0
[Receptor of advanced glycation endproducts RAGE/AGER: an integrative view for c [PMID:25486663]	Barbezier N, Tessier FJ, Chango A	Annales de biologie clinique	2014	0

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning AGER in their description or question text

No additional research found