gene

DCX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DCX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

131Connections

0Hypotheses

0Analyses

50Outgoing

35Incoming

0Experiments

0Debates

Summary

DCX is a gene implicated in neurodegeneration research. Key relationships include: activates, causes, implicated in. Associated with AD, ADH, ALI. Connected to 57 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DCX
Full Name	Doublecortin
Chromosome	Xq23
Function	encodes a microtubule-associated protein essential for neuronal migration and cortical layering during fetal brain development.
Primary Expression	adult neurogenic niches where it regulates neuronal differentiation, and its dysfunction has been implicated in [Alzheimer's disease](/diseases/alzhei
Amino Acids	366 aa
Pathways	Akt, Amyloid, Dendritic Spine, Differentiation, MAPK signaling
UniProt ID	[O43502](https://www.uniprot.org/uniprot/O43502)
Ensembl ID	ENSG00000077279
GeneCards	DCX
Human Protein Atlas	DCX
PKA	Ser297, Ser302 — reduces microtubule binding
[CDK5](/proteins/cdk5)	Ser297 — disrupts neuronal migration
MARK kinases	Ser322 — destabilizes microtubules
Associated Diseases	AD, ADH, ALI, Als, AMI
Interactions	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APP
KG Connections	131 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DCX Gene

gene · 1007 words

→

Doublecortin (DCX) Protein

protein · 672 words

→

Pathway Diagram

graph TD
    DCX["DCX"]
    Ms{"Ms"}
    DCX -->|"interacts with"| Ms
    Als{"Als"}
    DCX -->|"interacts with"| Als
    Ischemia{"Ischemia"}
    DCX -->|"activates"| Ischemia
    DCX -->|"activates"| Als
    DCX -->|"associated with"| Als
    DCX -->|"activates"| Ms
    Stroke{"Stroke"}
    DCX -->|"activates"| Stroke
    ALS{"ALS"}
    DCX -->|"causes"| ALS
    CDK5["CDK5"]
    DCX -->|"interacts with"| CDK5
    LIS1["LIS1"]
    DCX -->|"associated with"| LIS1
    DAB1["DAB1"]
    DCX -->|"interacts with"| DAB1
    PAFAH1B1["PAFAH1B1"]
    DCX -->|"associated with"| PAFAH1B1
    PAFAH1B1 -->|"associated with"| DCX
    DAB1 -->|"interacts with"| DCX
    NGF["NGF"]
    NGF -->|"activates"| DCX
    CDK5 -->|"associated with"| DCX
    DAB1 -->|"associated with"| DCX
    NESTIN["NESTIN"]
    NESTIN -->|"activates"| DCX
    CDK5 -->|"causes"| DCX
    AXON["AXON"]
    AXON -->|"causes"| DCX
    LIS1 -->|"causes"| DCX
    NEURON["NEURON"]
    NEURON -->|"causes"| DCX
    REELIN["REELIN"]
    REELIN -->|"causes"| DCX
    AND["AND"]
    AND -->|"causes"| DCX
    style DCX fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (96)

Target	Relation	Type	Str
Lissencephaly Type 1	causes	disease	0.95
Nucleokinesis	involved_in	process	0.90
nucleokinesis	regulates	process	0.90
Microtubules	interacts_with	compound	0.85
Type 1 Lissencephaly	causes	disease	0.85
Ischemia	activates	disease	0.75
Als	activates	disease	0.75
BDNF	activates	gene	0.70
neuroinflammation	activates	disease	0.70
Als	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Als	causes	disease	0.65
Alzheimer	activates	disease	0.65
ALS	causes	disease	0.65
Stroke	activates	disease	0.65
Ms	activates	disease	0.65
Ms	interacts_with	disease	0.65
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
TRKB	activates	gene	0.60
DYNEIN	causes	gene	0.60
PAFAH1B1	causes	gene	0.60
CDK5	causes	gene	0.60
LIS1	causes	gene	0.60
APP	activates	gene	0.60
SMAD4	activates	gene	0.60
MTOR	activates	gene	0.60
Dendritic Spine	activates	pathway	0.60
SMAD2	activates	gene	0.60
Dynein	causes	protein	0.60
Tubulin	activates	protein	0.60
Presenilin	activates	protein	0.60
PSD95	activates	gene	0.60
GFAP	expressed_in	gene	0.60
IBA1	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
TNF	activates	gene	0.60
VEGF	activates	gene	0.60
IBA1	activates	gene	0.60
DVL2	expressed_in	gene	0.60
SOX2	regulates	gene	0.60
SOX2	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
Amyloid	activates	pathway	0.60
Actin	causes	protein	0.60
hippocampus	expressed_in	brain_region	0.60
HIF	activates	gene	0.60
PCNA	activates	gene	0.60
CDK5	interacts_with	gene	0.60

Incoming (35)

Source	Relation	Type	Str
PRESENILIN	activates	gene	0.60
ROS	activates	gene	0.60
APP/PS1	activates	gene	0.60
AND	activates	gene	0.60
NESTIN	activates	gene	0.60
REELIN	causes	gene	0.60
PSD95	activates	gene	0.60
TRKB	activates	gene	0.60
TUBULIN	activates	gene	0.60
SMAD1	activates	gene	0.60
GFAP	activates	gene	0.60
APP	activates	gene	0.60
PAFAH1B1	causes	gene	0.60
BDNF	expressed_in	gene	0.60
MICROTUBULES	causes	gene	0.60
AMYLOID	activates	gene	0.60
NGF	activates	gene	0.60
CDK5	causes	gene	0.60
PI3K	activates	gene	0.60
BDNF	activates	gene	0.60
SMAD4	activates	gene	0.60
CREB	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
CDK5	associated_with	gene	0.60
DAB1	associated_with	gene	0.60
DAB1	causes	gene	0.60
DYNEIN	causes	gene	0.60
CD63	activates	gene	0.60
AXON	causes	gene	0.60
NEURON	causes	gene	0.60
PAFAH1B1	associated_with	gene	0.60
DAB1	interacts_with	gene	0.60
LIS1	causes	gene	0.60
STROKE	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DCX in their description or question text

No additional research found