protein

LIS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

0Hypotheses

0Analyses

34Outgoing

17Incoming

0Experiments

0Debates

Summary

LIS1 is a protein involved in neurodegeneration research. Key relationships include: interacts with, causes, implicated in. Associated with AD, ADH, ALI. Connected to 38 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	LIS1
Full Name	Lissencephaly 1
Chromosome	17p13.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	46 kDa
UniProt ID	[P43004](https://www.uniprot.org/uniprot/P43004)
Ensembl ID	ENSG00000007174
GeneCards	LIS1
Human Protein Atlas	LIS1
Neuronal progenitor positioning	Guides radial migration of neurons from ventricular zone to cortical plate
Leading process extension	Maintains stability of the leading process in migrating neurons
Nuclear translocation	Facilitates nuclear movement during somal translocation
Cortical layering	Ensures proper formation of cortical layers (1-6)
Ventricular zone	High expression in neural progenitor cells
Migrating neurons	Strong expression in the intermediate zone
Associated Diseases	AD, ADH, ALI, Als, AMI
Interactions	Actin, AND, CDK5, DAB1, DISC1, Dynein
KG Connections	51 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LIS1 Gene

gene · 1261 words

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LIS1 Protein

protein · 572 words

→

Pathway Diagram

graph TD
    LIS1["LIS1"]
    Ms{"Ms"}
    LIS1 -->|"interacts with"| Ms
    Als{"Als"}
    LIS1 -->|"interacts with"| Als
    LIS1 -->|"associated with"| Als
    Schizophrenia{"Schizophrenia"}
    LIS1 -->|"interacts with"| Schizophrenia
    ALS{"ALS"}
    LIS1 -->|"causes"| ALS
    DAB1["DAB1"]
    LIS1 -->|"interacts with"| DAB1
    PAFAH1B1["PAFAH1B1"]
    LIS1 -->|"associated with"| PAFAH1B1
    CDK5["CDK5"]
    LIS1 -->|"interacts with"| CDK5
    DISC1["DISC1"]
    LIS1 -->|"interacts with"| DISC1
    NEURON["NEURON"]
    LIS1 -->|"causes"| NEURON
    DCX["DCX"]
    LIS1 -->|"causes"| DCX
    DYNEIN["DYNEIN"]
    LIS1 -->|"interacts with"| DYNEIN
    DCX -->|"associated with"| LIS1
    CDK5 -->|"interacts with"| LIS1
    PAFAH1B1 -->|"associated with"| LIS1
    DAB1 -->|"interacts with"| LIS1
    CDK5 -->|"associated with"| LIS1
    DAB1 -->|"associated with"| LIS1
    NDEL1["NDEL1"]
    NDEL1 -->|"interacts with"| LIS1
    CDK5 -->|"causes"| LIS1
    AXON["AXON"]
    AXON -->|"causes"| LIS1
    REELIN["REELIN"]
    REELIN -->|"causes"| LIS1
    AND["AND"]
    AND -->|"interacts with"| LIS1
    NEURON -->|"causes"| LIS1
    style LIS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (34)

Target	Relation	Type	Str
NUCLEOKINESIS	regulates	entity	0.90
MICROTUBULE	interacts_with	entity	0.90
Schizophrenia	interacts_with	disease	0.65
ALS	causes	disease	0.65
Als	causes	disease	0.65
Als	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
DCX	causes	gene	0.60
DYNEIN	interacts_with	gene	0.60
PAFAH1B1	causes	gene	0.60
CDK5	causes	gene	0.60
Dynein	interacts_with	protein	0.60
DAB1	interacts_with	gene	0.60
PAFAH1B1	associated_with	gene	0.60
NEURON	causes	gene	0.60
MICROTUBULES	interacts_with	gene	0.60
Actin	interacts_with	protein	0.60
DISC1	interacts_with	gene	0.60
DAB1	causes	gene	0.60
REELIN	causes	gene	0.60
CDK5	interacts_with	gene	0.60
AXON	causes	gene	0.60
AND	interacts_with	gene	0.60
Neuron	causes	cell_type	0.60
Neuron	expressed_in	cell_type	0.55
Proteins	interacts_with	protein	0.50
AD	implicated_in	disease	0.50
ADH	implicated_in	disease	0.50
ALI	implicated_in	disease	0.50
AMI	implicated_in	disease	0.50
Ms	implicated_in	disease	0.50
RA	implicated_in	disease	0.50
SS	implicated_in	disease	0.50

Incoming (17)

Source	Relation	Type	Str
DCX	associated_with	gene	0.60
CDK5	interacts_with	gene	0.60
CDK5	associated_with	gene	0.60
DAB1	associated_with	gene	0.60
MICROTUBULES	interacts_with	gene	0.60
PAFAH1B1	associated_with	gene	0.60
DAB1	interacts_with	gene	0.60
NDEL1	interacts_with	gene	0.60
CDK5	causes	gene	0.60
DYNEIN	interacts_with	entity	0.60
AXON	causes	gene	0.60
NEURON	causes	gene	0.60
REELIN	causes	gene	0.60
DCX	causes	gene	0.60
DAB1	causes	gene	0.60
NUDEL	interacts_with	protein	0.50
PAFAH1B1	causes	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LIS1 in their description or question text

No additional research found