gene 2,811 words KG: PILRA
Contents

PILRA Gene

🧬 Gene Info
Gene SymbolPILRA
Full NamePaired Immunoglobulin-Like Type 2 Receptor Alpha
Chromosome7q22.1
Protein FamilyPaired immunoglobulin-like receptor family
Protein TypeReceptor
Functionis an inhibitory immune receptor expressed primarily on cells of the immune system.
Molecular Weight31 kDa
Amino Acids279 aa
UniProt IDQ9YH5Q
NCBI Gene ID9317
Ensembl IDENSG00000137216
OMIM604866
GeneCardsPILRA
Human Protein AtlasPILRA
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Atherosclerosis, Macular Degeneration
InteractionsABCA7, APOE, BIN1, MAF, PILRB, SORL1
KG Connections80 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

APOE-Dependent Autophagy Restoration
Score: 0.88
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Orexin-Microglia Modulation Therapy
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Oligodendrocyte White Matter Vulnerability
Score: 0.65
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58

Related Analyses (6)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (13)

ABCA7 (Redirect)
redirect · KG edge: associated_with
TNF (Redirect)
redirect · KG edge: associated_with
GRN Carrier Resilience: Why Some Mutation Carriers Rema
general · KG edge: therapeutic_target
Genes
index · KG edge: associated_with
ACE Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

ACE therapeutic_target PILRA
TREM2 therapeutic_target PILRA
PILRA therapeutic_target IDUA
PILRA therapeutic_target TAU
PILRA therapeutic_target GRN
PILRA associated_with ZCWPW1
PILRA associated_with MAF
PILRA associated_with ABCA7
PILRA associated_with TNF
TNF associated_with PILRA

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