gene

MDM4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MDM4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

152Connections

0Hypotheses

0Analyses

50Outgoing

44Incoming

0Experiments

0Debates

Summary

MDM4 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, therapeutic target, implicated in. Associated with AD, ALI, ALS. Connected to 106 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MDM4 (MDMX)
Full Name	MDM4 Proto-Oncogene
Chromosome	1q32.1
Function	MDM4 is a nuclear protein that contains a p53-binding domain and functions primarily as a transcriptional repressor[@toledo2007]:
Pathways	Epigenetic, Wnt signaling
UniProt ID	O15151
NCBI Gene ID	4193
Ensembl ID	ENSG00000198625
OMIM	602673
Direct Binding	MDM4 binds to p53 transactivation domain, inhibiting p53-mediated gene activation
Protein Stability	Unlike MDM2, MDM4 does not ubiquitinate p53; instead it stabilizes p53 protein
Feedback Regulation	p53 activates MDM4 expression, creating a balanced regulatory loop
G1/S Transition	MDM4 overexpression promotes G1/S cell cycle progression
S-Phase Entry	Modulates E2F1 activity for proper S-phase entry
Checkpoint Response	Negatively regulates p53-dependent cell cycle arrest
Associated Diseases	AD, ALI, Als, AMI, cancer
Interactions	AKT3, AND, APOB, APOPTOSIS, CANCER, CDKN2A
KG Connections	152 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MDM4 — AlphaFold O15151 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MDM4 (MDMX)

gene · 533 words

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Pathway Diagram

graph TD
    MDM4["MDM4"] -->|"therapeutic target"| Cancer["Cancer"]
    MDM4["MDM4"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    MDM4["MDM4"] -->|"therapeutic target"| Ms["Ms"]
    MDM4["MDM4"] -->|"therapeutic target"| Als["Als"]
    MDM4["MDM4"] -->|"associated"| Als_1["Als"]
    MDM4["MDM4"] -->|"associated"| Cancer_2["Cancer"]
    IDH1["IDH1"] -->|"therapeutic target"| MDM4["MDM4"]
    VEGFA["VEGFA"] -->|"therapeutic target"| MDM4["MDM4"]
    SF3B1["SF3B1"] -->|"therapeutic target"| MDM4["MDM4"]
    TERT["TERT"] -->|"therapeutic target"| MDM4["MDM4"]
    style MDM4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (108)

Target	Relation	Type	Str
Leukemia	regulates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Inflammation	regulates	disease	0.65
ALS	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	causes	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Parkinson	activates	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Als	associated_with	disease	0.65
Lymphoma	regulates	disease	0.65
Melanoma	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Tumor	expressed_in	disease	0.65
EEF1A1	therapeutic_target	gene	0.60
MCL1	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60
PDGFRA	activates	gene	0.60
PTEN	activates	gene	0.60
TERT	activates	gene	0.60
TP53	activates	gene	0.60
Dna Methylation	associated_with	pathway	0.60
Epigenetic	activates	pathway	0.60
WNT	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
PD-L1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
PD-1	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
SF3B1	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
P53	regulates	gene	0.60
Cell Cycle	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
PARKINSON'S DISEASE	activates	gene	0.60
PARKINSON	activates	gene	0.60
P53	activates	gene	0.60

Incoming (44)

Source	Relation	Type	Str
PD-L1	inhibits	gene	0.60
WNT	inhibits	gene	0.60
LZTR1	inhibits	gene	0.60
RNA	inhibits	gene	0.60
LZTR1	therapeutic_target	gene	0.60
WNT	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
PD-1	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
PD-L1	therapeutic_target	gene	0.60
SF3B1	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
EEF1A1	therapeutic_target	gene	0.60
EEF1A1	inhibits	gene	0.60
SF3B1	inhibits	gene	0.60
APOB	inhibits	gene	0.60
SMARCA4	inhibits	gene	0.60
MET	inhibits	gene	0.60
JUN	inhibits	gene	0.60
IDH1	inhibits	gene	0.60
MCL1	inhibits	entity	0.60
MET	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
GENES	inhibits	gene	0.60
DNA	inhibits	gene	0.60
P53	inhibits	gene	0.60
INFLAMMATION	regulates	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
MCL1	therapeutic_target	gene	0.60
AKT3	activates	gene	0.60
CDKN2A	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
APOB	associated_with	gene	0.60
EEF1A1	associated_with	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
IDH1	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
TERT	inhibits	gene	0.50
VEGFA	inhibits	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MDM4 in their description or question text

No additional research found