gene 3,150 words KG: IL1RAP
Contents

IL1RAP — Interleukin-1 receptor accessory protein

🧬 Gene Info
Gene SymbolIL1RAP
Full NameInterleukin-1 receptor accessory protein
Chromosome3q28
Protein TypeReceptor
Functionis a critical coreceptor for the interleukin-1 receptor family, essential for IL-1 signaling cascade activation.
Primary ExpressionMicroglia, Astrocytes, Spleen, Liver, Bone Marrow
Amino Acids570 aa
Exons12
UniProt IDQ9NPH8
NCBI Gene ID3556
Ensembl IDENSG00000124788
OMIM602463
GeneCardsIL1RAP
Human Protein AtlasIL1RAP
Extracellular domainThree immunoglobulin-like domains responsible for ligand binding and interaction with IL1R1/IL1R2
Associated DiseasesAlzheimer's Disease, Multiple Sclerosis, Glioma
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (15)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74

Related Analyses (9)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

See Also (15)

nct05508789
clinical_trial · Pages share 9 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypotheses
remternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses

Knowledge Graph (7 edges)

APOE expressed_in IL1RAP
CD33 expressed_in IL1RAP
GRN expressed_in IL1RAP
IL1RAP expressed_in TREM2
IL1RAP expressed_in microglia
IL1RAP data_in benchmark_ot_ad_answer_key:IL1RAP
benchmark_ot_ad_answer_key:IL1RAP data_in IL1RAP

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