gene

SF3B1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SF3B1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

176Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

SF3B1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, inhibits. Associated with AD, ALI, ALS. Connected to 118 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SF3B1
Full Name	Splicing Factor 3b Subunit 1
Chromosome	2q33.1
Function	is a gene located on chromosome 2q33.
Primary Expression	all cell types at moderate to high levels - Nuclear localization: The protein localizes to the nucleus, particularly the nucleolus - High turnov
Molecular Weight	146 kDa
Amino Acids	1308 aa
Exons	25
Pathways	Epigenetic, Immune Response, epigenetic regulation, inflammation
UniProt ID	O75533
NCBI Gene ID	6762
Ensembl ID	ENSG00000115523
GeneCards	SF3B1
Human Protein Atlas	SF3B1
N-terminal domain	Contains HEAT repeats that mediate protein-protein interactions
Associated Diseases	AD, ALI, Als, Alzheimer, AMI, cancer
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOB, ASXL1, CANCER
KG Connections	176 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SF3B1 — AlphaFold O75533 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SF3B1

gene · 2602 words

→

SF3B1 Protein

protein · 630 words

→

Pathway Diagram

graph TD
    SF3B1["SF3B1"]
    SF3B1 -->|"target for"| Cancer["Cancer"]
    SF3B1 -->|"target for"| Carcinoma["Carcinoma"]
    SF3B1 -->|"target for"| Ms["Ms"]
    SF3B1 -->|"target for"| Als["Als"]
    SF3B1 -->|"target for"| Cardiovascular["Cardiovascular"]
    SF3B1 -->|"activates"| Inflammation["Inflammation"]
    SF3B1 -->|"target for"| Alzheimer["Alzheimer"]
    SF3B1 -->|"target for"| Heart_Failure["Heart Failure"]
    SF3B1 -->|"target for"| Tumor["Tumor"]
    SF3B1 -->|"inhibits"| ALS["ALS"]
    IDH1["IDH1"] -->|"target for"| SF3B1
    VEGFA["VEGFA"] -->|"target for"| SF3B1
    MDM4["MDM4"] -->|"target for"| SF3B1
    APOB["APOB"] -->|"target for"| SF3B1
    ASXL1["ASXL1"] -->|"activates"| SF3B1
    DNMT3A["DNMT3A"] -->|"activates"| SF3B1
    FAS["FAS"] -->|"target for"| SF3B1
    JUN["JUN"] -->|"inhibits"| SF3B1
    MET["MET"] -->|"inhibits"| SF3B1

Outgoing (120)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:SF3B1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Immune Response	modulates	process	0.80
Immune Responses	modifies	process	0.80
Immune Cell Function	modulates	process	0.78
Cancer	therapeutic_target	disease	0.75
Als	associated_with	disease	0.75
Tumor	therapeutic_target	disease	0.75
Cancer	activates	disease	0.75
Immune Response	regulates	process	0.75
Heart Failure	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Alzheimer	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Heart Failure	associated_with	disease	0.65
Osteoporosis	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Breast Cancer	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
MDM4	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
ASXL1	activates	gene	0.60
MYC	therapeutic_target	gene	0.60
CD19	therapeutic_target	gene	0.60
APOB	inhibits	gene	0.60
TERT	inhibits	gene	0.60
IDH1	inhibits	gene	0.60
MET	inhibits	gene	0.60
JUN	inhibits	gene	0.60
MDM4	inhibits	gene	0.60
MCL1	inhibits	gene	0.60
VEGFA	inhibits	gene	0.60
MYC	associated_with	gene	0.60
Vegf	therapeutic_target	protein	0.60
Rb	therapeutic_target	protein	0.60
AND	activates	gene	0.60
SMARCA4	associated_with	gene	0.60
TERT	therapeutic_target	gene	0.60

Incoming (56)

Source	Relation	Type	Str
GBA intron-retained transcript	sequesters	RNA	0.00
benchmark_ot_ad_answer_key:SF3B1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ALZHEIMER'S DISEASE	activates	gene	0.60
U2AF1	activates	gene	0.60
TP53	activates	gene	0.60
TET2	activates	gene	0.60
DNA	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
WNT	therapeutic_target	gene	0.60
PD-L1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
PD-1	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
PPM1D	activates	gene	0.60
ASXL1	activates	gene	0.60
PD-L1	inhibits	gene	0.60
WNT	inhibits	gene	0.60
LZTR1	associated_with	gene	0.60
DNA	associated_with	gene	0.60
CANCER	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
RNA	inhibits	gene	0.60
IDH1	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
MDM4	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
APOB	associated_with	gene	0.60
EEF1A1	associated_with	gene	0.60
DNMT3A	activates	gene	0.60
U2AF1	associated_with	gene	0.60
FAS	therapeutic_target	gene	0.60
MDM4	inhibits	gene	0.60
JUN	inhibits	gene	0.60
MET	inhibits	gene	0.60
MCL1	inhibits	gene	0.60
VEGFA	inhibits	gene	0.60
SMARCA4	associated_with	gene	0.60
MCL1	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
CDK9	inhibits	gene	0.60
DYRK1A	inhibits	gene	0.60
CANCER	therapeutic_target	gene	0.60
GTPBP4	interacts_with	gene	0.60
DNA	co_discussed	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.645

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does the intron-retained RNA isoform mechanistically reduce glucocerebrosida

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Related Research

Hypotheses and analyses mentioning SF3B1 in their description or question text

No additional research found