gene 2,740 words KG: RAB2A
Contents

RAB2A Gene

🧬 Gene Info
Gene SymbolRAB2A
Full NameRAB GTPase 2A
Chromosome11p15.5
Functionis a critical small GTPase involved in intracellular vesicle trafficking, particularly within the endoplasmic reticulum (ER)-to-Golgi transport pathway and within Golgi compartments.
Subcellular Localizationmembranes and GDP-bound RAB2A being predominately cytosolic. This cycling is regulated by guanine nucleotide exchange fa
Molecular Weight21 kDa
Amino Acids185 aa
Pathwaysautophagy pathway, lipid trafficking, ubiquitin-proteasome
UniProt ID[P61019](https://www.uniprot.org/uniprot/P61019)
Ensembl IDENSG00000118890
OMIM614512
GeneCardsRAB2A
Human Protein AtlasRAB2A
Associated DiseasesAls, Ms
Known Drugs/Compoundsrapamycin
InteractionsAMPK, ATG, DNM1L, GABA, GABARAP, GABARAPL1
KG Connections109 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Autophagosome Maturation Checkpoint Control
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

GABA (Gamma-Aminobutyric Acid) - Neurodegenerative Dise
biomarker · KG edge: associated_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
DNM1L Gene
gene · KG edge: activates
GABARAP Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

GABARAP associated_with RAB2A
VAMP8 associated_with RAB2A
RTN3 associated_with RAB2A
LAMP2 associated_with RAB2A
DNM1L associated_with RAB2A
ULK1 associated_with RAB2A
LC3 associated_with RAB2A
MTOR associated_with RAB2A
RAB2A associated_with VAMP7
RAB2A associated_with STX17

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