gene

TKT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TKT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

0Hypotheses

0Analyses

50Outgoing

12Incoming

0Experiments

0Debates

Summary

TKT is a gene implicated in neurodegeneration research. Key relationships include: regulates, inhibits, implicated in. Associated with AD, ALS, AMI. Connected to 52 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TKT
Full Name	Transketolase
Chromosome	3p21.1
Protein Type	Enzyme
Function	Transketolase catalyzes transfers of two-carbon units in the non-oxidative PPP:
Molecular Weight	67.8 kDa
Amino Acids	623 aa
Pathways	Glycolysis
UniProt ID	P29597
NCBI Gene ID	7086
Ensembl ID	ENSG00000163798
OMIM	177027
GeneCards	TKT
Human Protein Atlas	TKT
Associated Diseases	AD, Als, AMI, ARM, cancer, carcinoma
Interactions	CANCER, CD8, GAIN, HIF, Hif-1, HIF-1Α
KG Connections	62 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TKT — AlphaFold P29597 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TKT Gene

gene · 783 words

→

TKT Protein

protein · 812 words

→

Pathway Diagram

graph TD
    TKT["TKT"]
    Cancer{"Cancer"}
    TKT -->|"activates"| Cancer
    Carcinoma{"Carcinoma"}
    TKT -->|"therapeutic target"| Carcinoma
    Ms{"Ms"}
    TKT -->|"activates"| Ms
    Als{"Als"}
    TKT -->|"activates"| Als
    ALS{"ALS"}
    TKT -->|"activates"| ALS
    TKT -->|"regulates"| Carcinoma
    Glycolysis(["Glycolysis"])
    TKT -->|"activates"| Glycolysis
    TIGAR["TIGAR"]
    TKT -->|"therapeutic target"| TIGAR
    GAIN["GAIN"]
    TKT -->|"activates"| GAIN
    IDH2["IDH2"]
    TKT -->|"therapeutic target"| IDH2
    CANCER["CANCER"]
    TKT -->|"activates"| CANCER
    TKT -->|"regulates"| TIGAR
    TIGAR -->|"therapeutic target"| TKT
    IDH2 -->|"therapeutic target"| TKT
    GAIN -->|"activates"| TKT
    HIF["HIF"]
    HIF -->|"activates"| TKT
    IDH2 -->|"regulates"| TKT
    AND["AND"]
    AND -->|"regulates"| TKT
    style TKT fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (50)

Target	Relation	Type	Str
IDH2	associated_with	entity	0.85
Poor Prognosis	associated_with	phenotype	0.80
Glycolysis	activates	pathway	0.70
Breast Cancer	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Hepatocellular Carcinoma	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Tumor	inhibits	disease	0.65
ALS	activates	disease	0.65
Carcinoma	regulates	disease	0.65
Senescence	inhibits	disease	0.65
Hif-1	activates	protein	0.60
Sumo	activates	protein	0.60
HIF-1Α	activates	gene	0.60
CANCER	regulates	gene	0.60
GENES	regulates	gene	0.60
Glycolysis	regulates	pathway	0.60
Blood-Brain Barrier	inhibits	pathway	0.60
Tumor Microenvironment	inhibits	pathway	0.60
Metastasis	inhibits	pathway	0.60
HIF	activates	gene	0.60
AND	regulates	gene	0.60
TIGAR	therapeutic_target	gene	0.60
GAIN	activates	gene	0.60
IDH2	therapeutic_target	gene	0.60
TIGAR	regulates	gene	0.60
FBP1	regulates	gene	0.60
TP53	regulates	gene	0.60
PDK1	regulates	gene	0.60
ENO1	regulates	gene	0.60
CD8	inhibits	gene	0.60
IDH2	regulates	gene	0.60
CANCER	activates	gene	0.60
AMI	implicated_in	disease	0.50
ARM	implicated_in	disease	0.50
Ms	implicated_in	disease	0.50
RA	implicated_in	disease	0.50
SS	implicated_in	disease	0.50
cancer	implicated_in	disease	0.50
AD	implicated_in	disease	0.50
carcinoma	implicated_in	disease	0.50
Als	implicated_in	disease	0.50

Incoming (12)

Source	Relation	Type	Str
PGK1	regulates	gene	0.60
GAPDH	regulates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
TIGAR	therapeutic_target	gene	0.60
IDH2	therapeutic_target	gene	0.60
GAIN	activates	gene	0.60
TIGAR	regulates	gene	0.60
IDH2	expressed_in	entity	0.60
TIGAR	expressed_in	entity	0.60
IDH2	regulates	gene	0.60
CTPS1	regulates	gene	0.60
HIF	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TKT in their description or question text

No additional research found