concept

LZTR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LZTR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

133Connections

0Hypotheses

0Analyses

50Outgoing

40Incoming

0Experiments

0Debates

Summary

LZTR1 is a concept in neurodegeneration research. Key relationships include: inhibits, implicated in, associated with. Associated with AD, ALI, ALS. Connected to 72 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	LZTR1
Key Genes/Proteins	AKT, AND, APOB, CANCER, DNA
Related Diseases	AD, ALI, Als, ALS, AMI
Related Pathways	Akt

Pathway Diagram

graph TD
    LZTR1["LZTR1"]
    LZTR1 -->|"causes"| Tumor["Tumor"]
    LZTR1 -->|"inhibits"| Als["Als"]
    LZTR1 -->|"inhibits"| Ms["Ms"]
    LZTR1 -->|"inhibits"| ALS["ALS"]
    LZTR1 -->|"inhibits"| Carcinoma["Carcinoma"]
    LZTR1 -->|"inhibits"| Cancer["Cancer"]
    LZTR1 -->|"inhibits"| SMARCB1["SMARCB1"]
    LZTR1 -->|"inhibits"| NF1["NF1"]
    LZTR1 -->|"inhibits"| Mapk["Mapk"]
    MTOR["MTOR"] -->|"inhibits"| LZTR1
    ERK["ERK"] -->|"inhibits"| LZTR1
    PI3K["PI3K"] -->|"inhibits"| LZTR1
    AKT["AKT"] -->|"inhibits"| LZTR1
    NF2["NF2"] -->|"inhibits"| LZTR1
    MDM4["MDM4"] -->|"inhibits"| LZTR1
    JUN["JUN"] -->|"inhibits"| LZTR1
    MET["MET"] -->|"inhibits"| LZTR1
    MCL1["MCL1"] -->|"inhibits"| LZTR1
    VEGFA["VEGFA"] -->|"inhibits"| LZTR1

Outgoing (93)

Target	Relation	Type	Str
Tumor	inhibits	disease	0.85
Als	inhibits	disease	0.75
neurofibromatosis	associated_with	disease	0.70
GENES	inhibits	gene	0.70
Tumor	causes	disease	0.70
schwannomatosis	associated_with	disease	0.70
RAS	inhibits	gene	0.65
Cancer	inhibits	disease	0.65
Ms	inhibits	disease	0.65
UBIQUITIN	inhibits	gene	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
RNA	inhibits	gene	0.60
MDM4	inhibits	gene	0.60
SMARCA4	associated_with	gene	0.60
TERT	inhibits	gene	0.60
JUN	inhibits	gene	0.60
AND	associated_with	gene	0.60
CANCER	inhibits	gene	0.60
IDH1	inhibits	gene	0.60
DNA	associated_with	gene	0.60
PD-1	inhibits	gene	0.60
VEGFA	inhibits	gene	0.60
MCL1	inhibits	gene	0.60
MET	inhibits	gene	0.60
VEGFA	therapeutic_target	gene	0.60
WNT	therapeutic_target	gene	0.60
PD-L1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
PD-1	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60
Dna Methylation	therapeutic_target	pathway	0.60
Wnt	therapeutic_target	pathway	0.60
MAPK	inhibits	gene	0.60
MCL1	therapeutic_target	gene	0.60
RAS	degrades	gene	0.60
Mapk	degrades	pathway	0.60
MDM4	therapeutic_target	gene	0.60
Vegf	therapeutic_target	protein	0.60
Rb	therapeutic_target	protein	0.60
Erk	therapeutic_target	protein	0.60
MAPK	degrades	gene	0.60

Incoming (40)

Source	Relation	Type	Str
28622513	is identified as	paper	0.90
SUST	associated_with	gene	0.70
SMARCB1	inhibits	gene	0.70
NF2	inhibits	gene	0.70
EEF1A1	associated_with	gene	0.60
MDM4	inhibits	gene	0.60
JUN	inhibits	gene	0.60
MET	inhibits	gene	0.60
DNA	associated_with	gene	0.60
MCL1	inhibits	gene	0.60
VEGFA	inhibits	gene	0.60
SMARCA4	associated_with	gene	0.60
SF3B1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
MTOR	inhibits	gene	0.60
APOB	inhibits	gene	0.60
TERT	inhibits	gene	0.60
CANCER	inhibits	gene	0.60
IDH1	inhibits	gene	0.60
SMARCB1	causes	gene	0.60
GAIN	therapeutic_target	gene	0.60
NF2	causes	gene	0.60
NF1	inhibits	gene	0.60
RAS	inhibits	gene	0.60
PD-L1	inhibits	gene	0.60
WNT	inhibits	gene	0.60
P53	inhibits	gene	0.60
ERK	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
AKT	inhibits	gene	0.60
MCL1	therapeutic_target	gene	0.60
MDM4	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
WNT	therapeutic_target	gene	0.60
AND	inhibits	gene	0.60
MAPK	degrades	gene	0.60
AND	contributes_to	gene	0.60
MAPK	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LZTR1 in their description or question text

No additional research found