gene 3,426 words KG: HRAS
Contents

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

🧬 Gene Info
Gene SymbolHRAS
Chromosome11p15.5
Protein TypeGene
Functionis a prototype member of the Ras family of small GTPases that functions as a molecular switch in intracellular signaling pathways.
Primary Expressionmedium spiny neurons of the striatum and in dopaminergic neurons of the substantia nigra pars compacta
Amino Acids188 aa
Exons6
PathwaysNF-κB
UniProt IDP01112
NCBI Gene ID3265
Ensembl IDENSG00000174775
GeneCardsHRAS
Human Protein AtlasHRAS
Associated DiseasesAls, cancer, Fibrosis, Inflammation
InteractionsAKT, AND, BRAF, CANCER, GENE MUTATIONS, GENES
KG Connections249 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
Arginine Methylation Enhancement Therapy
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51

Related Analyses (9)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (8)

BCL2L1 Gene
gene · KG edge: therapeutic_target
BRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase
gene · KG edge: activates
CALM1 — Calmodulin 1
gene · KG edge: therapeutic_target
CYCS
gene · KG edge: therapeutic_target
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: associated_with

Knowledge Graph (12 edges)

KCNH2 therapeutic_target HRAS
IDH1 therapeutic_target HRAS
TP53 therapeutic_target HRAS
SCN5A therapeutic_target HRAS
IL1B therapeutic_target HRAS
KCNQ1 therapeutic_target HRAS
TNF therapeutic_target HRAS
CALM1 therapeutic_target HRAS
LMNA therapeutic_target HRAS
HRAS therapeutic_target DRD2

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