protein

CD2AP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD2AP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

491Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

10Experiments

0Debates

Summary

CD2AP is a protein involved in neurodegeneration research. Key relationships include: co discussed, associated with, implicated in. Associated with AD, ALI, ALS. Connected to 70 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CD2AP
Full Name	CD2-Associated Protein
Chromosome	6p12.3
Protein Family	SH3 domain-containing adaptor proteins
Function	is a scaffolding protein that plays critical roles in immune cell signaling, cytoskeletal organization, and receptor trafficking.
Primary Expression	the brain, pa
Molecular Weight	70 kDa
Amino Acids	639 aa
Exons	13
Gene Type	Protein coding
Pathways	Endocytosis
UniProt ID	Q9Y5K7
NCBI Gene ID	9501
Ensembl ID	ENSG00000198034
OMIM	604332
GeneCards	CD2AP
Human Protein Atlas	CD2AP
Associated Diseases	AD, ALI, Als, Alzheimer, Alzheimer's disease
Interactions	ABCA1, ABCA7, Actin, AD, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	491 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CD2AP — AlphaFold Q9Y5K7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD2AP["CD2AP"]
    Cerebrovascular_Dysfunction["Cerebrovascular Dysfunction"]
    CD2AP -->|"causes"| Cerebrovascular_Dysfunction
    Endothelial_Cells["Endothelial Cells"]
    CD2AP -->|"expressed in"| Endothelial_Cells
    Cerebrovascular_Function(["Cerebrovascular Function"])
    CD2AP -->|"involved in"| Cerebrovascular_Function
    Blood_Brain_Barrier_Function(["Blood-Brain Barrier Function"])
    CD2AP -->|"regulates"| Blood_Brain_Barrier_Function
    Alzheimer_s_disease{"Alzheimer's disease"}
    CD2AP -->|"associated with"| Alzheimer_s_disease
    p38_MAPK["p38 MAPK"]
    CD2AP -->|"regulates"| p38_MAPK
    neuron["neuron"]
    CD2AP -->|"expressed in"| neuron
    tau_pathology(["tau pathology"])
    CD2AP -->|"regulates"| tau_pathology
    Alzheimer{"Alzheimer"}
    CD2AP -->|"associated with"| Alzheimer
    Ms{"Ms"}
    CD2AP -->|"associated with"| Ms
    Als{"Als"}
    CD2AP -->|"inhibits"| Als
    ALS{"ALS"}
    CD2AP -->|"inhibits"| ALS
    REST["REST"]
    REST -->|"activates"| CD2AP
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"inhibits"| CD2AP
    NEURON["NEURON"]
    NEURON -->|"inhibits"| CD2AP
    REELIN["REELIN"]
    REELIN -->|"activates"| CD2AP
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| CD2AP
    ALZHEIMER -->|"co discussed"| CD2AP
    ALZHEIMER_S["ALZHEIMER'S"]
    ALZHEIMER_S -->|"co discussed"| CD2AP
    APOE["APOE"]
    APOE -->|"co discussed"| CD2AP
    style CD2AP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (324)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CD2AP	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
CEREBROVASCULAR DYSFUNCTION	associated_with	entity	0.95
Cerebrovascular Dysfunction	causes	phenotype	0.95
Microglia	expressed_in	cell_type	0.92
Cerebrovascular Function	involved_in	process	0.90
Endothelial Cells	expressed_in	cell_type	0.90
ENDOTHELIAL CELL	expressed_in	entity	0.90
Alzheimer's Disease	risk_factor_for	disease	0.88
Disease-Associated Microglia Formation	involved_in	process	0.85
Sex-Dependent Phenotype	associated_with	phenotype	0.85
blood-brain barrier	regulates	process	0.85
ALZHEIMER'S DISEASE	associated_with	entity	0.85
Blood-Brain Barrier Function	involved_in	process	0.85
cerebral blood flow	regulates	phenotype	0.80
Cerebrovascular Function	regulates	biological_process	0.80
Blood-Brain Barrier Function	regulates	process	0.80
microglia	expressed_in	cell_type	0.80
C1Q	correlates_with	protein	0.80
vascular permeability	modulates	phenotype	0.80
Vascular Permeability	regulates	phenotype	0.75
neurovascular coupling	involved_in	process	0.75
NEURONS	expressed_in	cell_type	0.70
ENDOTHELIAL	expressed_in	cell_type	0.70
MICROGLIA	expresses	cell_type	0.70
LDLR	activates	gene	0.70
TAU	mediates	gene	0.70
TAU	disrupts	gene	0.70
GRN	causes	gene	0.70
MICROGLIA	disrupts	cell_type	0.70
tau pathology	regulates	process	0.70
neuron	expressed_in	cell_type	0.70
p38 MAPK	regulates	protein	0.70
Alzheimer's disease	associated_with	disease	0.70
CLCN1	causes	gene	0.70
neurodegeneration	causes	disease	0.70
Alzheimer's disease	interacts_with	disease	0.70
endothelial cells	expressed_in	cell_type	0.70
Cognitive Decline	risk_factor_for	phenotype	0.70
MICROGLIA	regulates	cell_type	0.65
Alzheimer	activates	disease	0.65
MICROGLIA	inhibits	cell_type	0.65
MICROGLIA	causes	cell_type	0.65
STING	regulates	gene	0.65
ALS	associated_with	disease	0.65
CSF1R	activates	gene	0.65
CLU	associated_with	gene	0.65
STING	protects_against	gene	0.65
Neuroinflammation	associated_with	disease	0.65
MICROGLIA	associated_with	cell_type	0.65

Incoming (167)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CD2AP	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ALZHEIMER DISEASE	associated_with	gene	0.80
APP	disrupts	gene	0.70
APOE	expresses	gene	0.70
ARRB2	causes	gene	0.70
BIN1	causes	gene	0.70
ALZHEIMER'S DISEASE	associated_with	disease	0.65
ALZHEIMER'S	associated_with	disease	0.65
RNA	activates	gene	0.60
GENES	regulates	gene	0.60
GENES	activates	gene	0.60
APOE	activates	gene	0.60
PTK2B	interacts_with	gene	0.60
CASS4	interacts_with	gene	0.60
ABCA1	activates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
MAPK	activates	gene	0.60
CD2AP DEFICIENCY	therapeutic_target	gene	0.60
TAU PATHOLOGY	associated_with	gene	0.60
ALZHEIMER	activates	gene	0.60
NEURON	activates	gene	0.60
APOER2	activates	gene	0.60
PHAGOCYTOSIS	expressed_in	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
ENDOSOME	regulates	gene	0.60
LNCRNA	activates	gene	0.60
SYNAPSE	associated_with	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
AND	associated_with	gene	0.60
APOER2	protects_against	gene	0.60
MICROGLIA	protects_against	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	inhibits	gene	0.60
CD2AP GENE	associated_with	gene	0.60
CD2AP DEFICIENCY	protects_against	gene	0.60
RNA	associated_with	gene	0.60
AD	interacts_with	gene	0.60
AD	disrupts	gene	0.60
AD	expresses	gene	0.60
ALZHEIMER'S DISEASE	co_discussed	disease	0.60
AD	inhibits	gene	0.60
APOE	protects_against	gene	0.60
AΒ	protects_against	gene	0.60
AD	targets	gene	0.60
REST	activates	gene	0.60
REELIN	activates	gene	0.60
SORL1	regulates	gene	0.60
APP	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
CD2AP downregulation in brain endothelial cells - memory function	validation	Alzheimer's disease	0.900	mice	proposed	N/A
Reelin glycoprotein treatment rescue experiment	validation	Alzheimer's disease	0.900	mice	proposed	N/A
Cerebrovascular function analysis in CD2AP mutant mice	validation	Alzheimer's disease	0.900	mice	proposed	N/A
Endothelial CD2AP knockdown effects on memory in male mice	validation	Alzheimer's disease	0.900	male mice	proposed	N/A
Cerebral blood flow regulation in CD2AP mutant mice	validation	Alzheimer's disease	0.880	mice	proposed	N/A
Reelin treatment rescue via ApoER2 in CD2AP mutant mice	validation	Alzheimer's disease	0.870	mice	proposed	N/A
Endothelin-1 receptor A antagonist rescue experiment	validation	Alzheimer's disease	0.850	mice	proposed	N/A
Endothelin-1 receptor A antagonist rescue in male CD2AP mice	validation	Alzheimer's disease	0.850	male mice	proposed	N/A
CD2AP loss association with cognitive decline in AD patients	exploratory	Alzheimer's disease	0.850	human patients	proposed	N/A
CD2AP expression and cognitive decline in AD patients	exploratory	Alzheimer's disease	0.800	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD2AP in their description or question text

No additional research found