concept

GLUT4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLUT4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

322Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

GLUT4 is a concept in neurodegeneration research. Key relationships include: activates, protects against, inhibits. Associated with AD, Aging, Als. Connected to 146 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	GLUT4
Key Genes/Proteins	Actin, AKT, AKT2 Protein, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
Related Diseases	AD, Aging, Als, ALS, Alzheimer
Related Pathways	Akt
Linked Hypotheses	1 hypotheses

Pathway Diagram

graph TD
    GLUT4["GLUT4"]
    GLUT4 -->|"activates"| Diabetes["Diabetes"]
    GLUT4 -->|"activates"| Obesity["Obesity"]
    GLUT4 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    GLUT4 -->|"activates"| Inflammation["Inflammation"]
    GLUT4 -->|"activates"| Aging["Aging"]
    GLUT4 -->|"activates"| Ms["Ms"]
    GLUT4 -->|"target for"| Stroke["Stroke"]
    GLUT4 -->|"activates"| Fibrosis["Fibrosis"]
    GLUT4 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    GLUT4 -->|"activates"| Alzheimer["Alzheimer"]
    CYP2E1["CYP2E1"] -->|"inhibits"| GLUT4
    NRF2["NRF2"] -->|"inhibits"| GLUT4
    FGFR1["FGFR1"] -->|"activates"| GLUT4
    FGF21["FGF21"] -->|"activates"| GLUT4
    SOD2["SOD2"] -->|"activates"| GLUT4
    BACE1["BACE1"] -->|"activates"| GLUT4
    PI3K["PI3K"] -->|"activates"| GLUT4
    MTOR["MTOR"] -->|"inhibits"| GLUT4
    PLIN1["PLIN1"] -->|"activates"| GLUT4
    AND["AND"] -->|"activates"| GLUT4

Outgoing (210)

Target	Relation	Type	Str
Brain Glucose Metabolism	involved_in	process	0.90
Obesity	activates	disease	0.75
Als	activates	disease	0.75
Alzheimer	activates	disease	0.75
Als	protects_against	disease	0.75
Neurodegeneration	protects_against	disease	0.75
AKT	activates	gene	0.70
AMPK	activates	gene	0.70
Cholesterol	activates	pathway	0.70
SIRT1	activates	gene	0.70
Parkinson	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Obesity	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Metabolic Syndrome	therapeutic_target	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Aging	activates	disease	0.65
Diabetes	activates	disease	0.65
Ms	activates	disease	0.65
Stroke	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	protects_against	disease	0.65
Als	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Type 2 Diabetes	protects_against	disease	0.65
Insulin Resistance	biomarker_for	disease	0.65
Dementia	protects_against	disease	0.65
Neuropathy	protects_against	disease	0.65
Diabetes	protects_against	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroblastoma	biomarker_for	disease	0.65
GFAP	regulates	gene	0.65
GFAP	activates	gene	0.65
EPILEPSY	transports	disease	0.65
INSULIN SIGNALING	regulates	pathway	0.65
ALS	protects_against	disease	0.65
TSC2	activates	gene	0.65
Inflammation	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Rheumatoid Arthritis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
PPARG	activates	gene	0.60
PPAR	activates	gene	0.60

Incoming (112)

Source	Relation	Type	Str
TUG	interacts_with	entity	0.95
TUG	binds	protein	0.90
NRF2	inhibits	protein	0.90
CYP2E1	inhibits	protein	0.90
TUG	regulates	protein	0.90
h-075f1f02	targets_gene	hypothesis	0.90
AMPK	activates	protein	0.85
NEURODEGENERATION	protects_against	gene	0.70
NEURONS	activates	cell_type	0.70
AKT	causes	gene	0.70
NEURODEGENERATION	inhibits	phenotype	0.70
AKT	phosphorylates	gene	0.70
ASTROCYTES	inhibits	cell_type	0.65
ASTROCYTES	activates	cell_type	0.65
ROS	inhibits	gene	0.60
TNF	inhibits	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
SOD1	activates	gene	0.60
NOX4	activates	gene	0.60
PI3K	activates	gene	0.60
PTEN	inhibits	gene	0.60
NEURODEGENERATIVE DISORDERS	protects_against	gene	0.60
SOD2	protects_against	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
GENES	protects_against	gene	0.60
SOD1	protects_against	gene	0.60
CREB	activates	gene	0.60
NLGN2	protects_against	gene	0.60
APP/PS1	activates	gene	0.60
DIABETES MELLITUS	therapeutic_target	gene	0.60
PER	protects_against	gene	0.60
GSK3B	protects_against	gene	0.60
COX4I1	protects_against	gene	0.60
FGFR1	activates	gene	0.60
AKT	activates	gene	0.60
BDNF	protects_against	gene	0.60
CYCS	protects_against	gene	0.60
AMPK	regulates	gene	0.60
AMPK	treats	gene	0.60
OXIDATIVE STRESS	protects_against	gene	0.60
FGF21	activates	gene	0.60
SOD2	activates	gene	0.60
BACE1	activates	gene	0.60
MTOR	inhibits	gene	0.60
INFLAMMATION	protects_against	gene	0.60
NRXN3	protects_against	gene	0.60
PDHA1	protects_against	gene	0.60
BDNF	activates	gene	0.60
PRKAA1	protects_against	gene	0.60
APOPTOSIS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Metabolic reprogramming in neurodegenerative disease

neurodegeneration | 2026-04-02 | 3 hypotheses Top: 0.652

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does metabolic reprogramming (glucose metabolism shifts, brain insulin resis

closed · Rounds: 4 · Score: 0.73 · 2026-04-02

Related Research

Hypotheses and analyses mentioning GLUT4 in their description or question text

No additional research found