gene

APOB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APOB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

152Connections

0Hypotheses

0Analyses

50Outgoing

40Incoming

0Experiments

0Debates

Summary

APOB is a gene implicated in neurodegeneration research. Key relationships include: inhibits, therapeutic target, associated with. Associated with AD, ADH, ALI. Connected to 112 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	APOB
Full Name	Apolipoprotein B
Chromosome	Chr2p24.1
Function	The APOB gene encodes Apolipoprotein B, the main structural protein of very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) particles.
Pathways	Cholesterol, Dna Methylation, Wnt
UniProt ID	P04114
NCBI Gene ID	338
Ensembl ID	ENSG00000184677
OMIM	107730
GeneCards	APOB
Human Protein Atlas	APOB
APOB-100	Full-length protein synthesized in liver, found on VLDL/LDL
APOB-48	Truncated form from intestinal mRNA, found on chylomicrons
N-terminal region	Lipid-binding beta-sheet structure (LDLR binding)
Central region	Large beta-sheet domains
Associated Diseases	AD, ADH, ALI, Als, AMI, cancer
Interactions	AND, CANCER, DNA, EEF1A1, GENES, IDH1
KG Connections	152 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: APOB — AlphaFold P04114 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

APOB Gene

gene · 609 words

→

APOB Protein

protein · 626 words

→

Pathway Diagram

graph TD
    APOB["APOB"] -->|"causes"| ADH["ADH"]
    APOB["APOB"] -->|"therapeutic target"| Cancer["Cancer"]
    APOB["APOB"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    APOB["APOB"] -->|"therapeutic target"| Ms["Ms"]
    APOB["APOB"] -->|"therapeutic target"| Als["Als"]
    APOB["APOB"] -->|"expressed in"| Cardiovascular["Cardiovascular"]
    IDH1["IDH1"] -->|"therapeutic target"| APOB["APOB"]
    VEGFA["VEGFA"] -->|"therapeutic target"| APOB["APOB"]
    MDM4["MDM4"] -->|"therapeutic target"| APOB["APOB"]
    SF3B1["SF3B1"] -->|"therapeutic target"| APOB["APOB"]
    style APOB fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (112)

Target	Relation	Type	Str
Microglia	binds	cell_type	0.93
Alzheimer's Disease	contributes_to	disease	0.90
Autosomal Dominant Hypercholesterolemia	risk_factor_for	disease	0.90
ADH	causes	disease	0.72
Als	associated_with	disease	0.65
Fatty Liver	therapeutic_target	disease	0.65
Cardiovascular	associated_with	disease	0.65
Cardiac	expressed_in	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Nafld	causes	disease	0.65
Ms	therapeutic_target	disease	0.65
ALS	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	associated_with	disease	0.65
Hypertension	expressed_in	disease	0.65
Ischemia	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Metabolic Syndrome	contributes_to	disease	0.65
Atherosclerosis	contributes_to	disease	0.65
Erk	therapeutic_target	protein	0.60
Cholesterol	contributes_to	pathway	0.60
WNT	therapeutic_target	gene	0.60
LZTR1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
PD-L1	therapeutic_target	gene	0.60
AND	expressed_in	gene	0.60
Dna Methylation	therapeutic_target	pathway	0.60
Wnt	therapeutic_target	pathway	0.60
CANCER	inhibits	gene	0.60
LZTR1	inhibits	gene	0.60
Dna Methylation	inhibits	pathway	0.60
Wnt	inhibits	pathway	0.60
MCL1	associated_with	gene	0.60
MDM4	associated_with	gene	0.60
SF3B1	associated_with	gene	0.60
SMARCA4	associated_with	gene	0.60
TERT	associated_with	gene	0.60
VEGFA	associated_with	gene	0.60
TERT	inhibits	gene	0.60
IDH1	inhibits	gene	0.60
SMARCA4	inhibits	gene	0.60
JUN	inhibits	gene	0.60

Incoming (40)

Source	Relation	Type	Str
EEF1A1	inhibits	gene	0.60
MDM4	inhibits	gene	0.60
JUN	inhibits	gene	0.60
MET	inhibits	gene	0.60
MCL1	inhibits	gene	0.60
VEGFA	inhibits	gene	0.60
SMARCA4	inhibits	gene	0.60
SF3B1	inhibits	gene	0.60
IL-6	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
LZTR1	therapeutic_target	gene	0.60
WNT	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
PD-L1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
PD-1	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
EEF1A1	therapeutic_target	gene	0.60
DNA	inhibits	gene	0.60
GENES	inhibits	gene	0.60
P53	inhibits	gene	0.60
PD-L1	inhibits	gene	0.60
WNT	inhibits	gene	0.60
LZTR1	inhibits	gene	0.60
GENES	expressed_in	gene	0.60
PCSK9	expressed_in	gene	0.60
IDH1	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
MDM4	therapeutic_target	gene	0.60
CCS	associated_with	gene	0.60
ABCB1	regulates	gene	0.60
SF3B1	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
APOE	regulates	gene	0.60
LDLR	regulates	gene	0.60
LRP6	contributes_to	gene	0.60
LDLR	expressed_in	gene	0.60
MCL1	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning APOB in their description or question text

No additional research found