gene

RELN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RELN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

295Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

3Experiments

1Debates

Summary

RELN is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, protects against, implicated in. Associated with AD, AMI, Aging. Connected to 82 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RELN
Full Name	Reelin
Chromosome	7q22.1
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	The protein contains an N-terminal signal peptide followed by 8 reelin repeat domains (R1-R8), each approximately 350 amino acids in length.
Mechanism of Action	Drugs targeting RELN would primarily work by enhancing reelin expression or signaling through its receptors (VLDLR and ApoER2) to promote neuronal migration, synaptic plasticity, and cognitive function. Alternatively, pathway modulators could enhance downstream signaling cascades (Dab1-mediated pathways) to compensate for reelin deficiency or dysfunction.
Primary Expression	migrating neurons and mature neurons, VLDLR mediates reelin signaling involved in neuronal positioning and synaptic function [4](https://pubmed
Druggability	Low (0.33)
Clinical Stage	Approved
Molecular Weight	400 kDa
Amino Acids	350 aa
Pathways	Epigenetic, Reelin-Mediated Cytoskeletal Stabilization Protoco
UniProt ID	P78509
Ensembl ID	ENSG00000189056
GeneCards	RELN
Human Protein Atlas	RELN
Associated Diseases	AD, Als, Alzheimer, Alzheimer disease
Known Drugs/Compounds	valproic acid
Interactions	AD, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE
SciDEX Target	View Target Profile (9 clinical trials)
SciDEX Hypotheses	Reelin-Mediated Cytoskeletal Stabilization Protoco
KG Connections	295 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: RELN — AlphaFold P78509 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RELN Gene

gene · 1603 words

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Pathway Diagram

graph TD
    RELN["RELN"] -->|"regulates"| Reelin_Mediated_Cytoskeletal_S["Reelin-Mediated Cytoskeletal Stabilization Protoco"]
    RELN["RELN"] -->|"protects against"| Alzheimer["Alzheimer"]
    RELN["RELN"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    RELN["RELN"] -->|"interacts"| Schizophrenia["Schizophrenia"]
    RELN["RELN"] -->|"therapeutic target"| Dementia["Dementia"]
    RELN["RELN"] -->|"interacts"| Alzheimer_1["Alzheimer"]
    h_d2df6eaf["h-d2df6eaf"] -->|"therapeutic target"| RELN["RELN"]
    h_d2df6eaf_2["h-d2df6eaf"] -->|"targets"| RELN["RELN"]
    JUN["JUN"] -->|"protects against"| RELN["RELN"]
    APOE["APOE"] -->|"associated"| RELN["RELN"]
    style RELN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (158)

Target	Relation	Type	Str
VLDLR	binds	protein	0.95
APOE	associated_with	entity	0.95
Apoer2	binds	protein	0.95
NEURONAL MIGRATION	regulates	entity	0.95
superficial dorsal horn	expressed_in	brain_region	0.95
VLDLR	binds_to	entity	0.95
SYNAPTOGENESIS	regulates	entity	0.95
DENDRITIC GROWTH	regulates	entity	0.95
DENDRITIC SPINE FORMATION	regulates	entity	0.95
SYNAPTIC PLASTICITY	regulates	entity	0.95
neuronal lamination	regulates	process	0.90
ALZHEIMER'S DISEASE	associated_with	entity	0.90
neuron positioning in dorsal horn	regulates	process	0.90
DAB1	interacts_with	protein	0.90
dendritic growth and branching	regulates	process	0.90
Alzheimer'S Disease	protects_against	disease	0.85
Lissencephaly	associated_with	disease	0.85
EPILEPSY	implicated_in	entity	0.85
DEPRESSION	implicated_in	entity	0.85
Heart Development	involved_in	process	0.85
AUTISM	implicated_in	entity	0.85
SCHIZOPHRENIA	implicated_in	entity	0.85
synaptic function	regulates	process	0.85
Alzheimer'S Disease	associated_with	disease	0.85
BIPOLAR DISORDER	implicated_in	entity	0.85
Heart Injury Repair	involved_in	process	0.85
dI5 neuron migration	mediates	process	0.85
Neuronal Architecture Formation	regulates	process	0.85
lamina I positioning defect	implicated_in	phenotype	0.80
HIPPOCAMPUS	expressed_in	entity	0.80
Lissencephaly	causes	disease	0.80
CORTEX	expressed_in	entity	0.80
disease progression	modulates	phenotype	0.80
lamina V	contributes_to	brain_region	0.80
regenerative response	drives	process	0.80
reelin_protein	encodes	protein	0.80
microglia regenerative response	upregulates	process	0.75
heart development	regulates	process	0.75
TREM2	protects_against	gene	0.70
Alzheimer's Disease	risk_factor_for	disease	0.70
injury repair	promotes	process	0.70
Reelin-Mediated Cytoskeletal Stabilization Protoco	regulates	mechanism	0.70
Epilepsy	therapeutic_target	disease	0.65
Alzheimer	protects_against	disease	0.65
anti-HSV1-gD antibody levels	modulates	phenotype	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	interacts_with	disease	0.65

Incoming (137)

Source	Relation	Type	Str
CDH5	regulates	protein	0.95
CDH5	mediates	protein	0.90
SRC	interacts_with	entity	0.90
FYN	interacts_with	entity	0.90
h-d2df6eaf	targets	hypothesis	0.90
Km Allotype	interacts_with	biomarker	0.75
NEURONS	activates	cell_type	0.70
MICROGLIA	activates	cell_type	0.70
NEURONS	markers	cell_type	0.70
GLUTAMATERGIC	expresses	cell_type	0.70
NEURONS	expresses	cell_type	0.70
APOE	biomarker_for	gene	0.70
GABAERGIC	activates	cell_type	0.70
GRIN2B	associated_with	gene	0.70
CLU	associated_with	gene	0.70
PICALM	markers	gene	0.70
APP	protects_against	gene	0.70
BDNF	protects_against	gene	0.70
CR1	protects_against	gene	0.70
NFKB	activates	gene	0.70
PICALM	protects_against	gene	0.70
APOE	associated_with	gene	0.60
ALZHEIMER	activates	gene	0.60
DEMENTIA	protects_against	gene	0.60
AND	activates	gene	0.60
FN1	interacts_with	gene	0.60
DNA	activates	gene	0.60
NEURON	expresses	cell_type	0.60
AD	protects_against	gene	0.60
GABAERGIC	enhances	cell_type	0.60
NEURON	enhances	cell_type	0.60
NEURONS	enhances	cell_type	0.60
BIN1	associated_with	gene	0.60
CNP	associated_with	gene	0.60
MAG	associated_with	gene	0.60
MOG	associated_with	gene	0.60
RAB10	interacts_with	gene	0.60
AMYLOID	activates	gene	0.60
APOE3	activates	gene	0.60
PLCG2	interacts_with	gene	0.60
APOER2	interacts_with	gene	0.60
ATP8B1	interacts_with	gene	0.60
CLU	interacts_with	gene	0.60
NPTX2	interacts_with	gene	0.60
PICALM	interacts_with	gene	0.60
CAV1	targets	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60
APOE3	interacts_with	gene	0.60
valproic acid	activates	compound	0.60
valproic acid	inhibits	compound	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Reelin-Mediated Cytoskeletal Stabilization Protocol	0.689	neurodegeneration	Selective vulnerability of entorhinal co

Mentioning Analyses (1)

Scientific analyses that reference this entity

Selective vulnerability of entorhinal cortex layer II neurons in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.696

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
REL transcription factor mediates VLC ceramide-driven inflammation	exploratory	inflammation	0.750	0.00	innate immune cells	proposed	N/A
Levodopa Response Determinants in PSP — Biomarker-Guided Prediction St	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Neural Stem Cell Therapy for Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Loss of endothelial CD2AP causes sex-dependent cerebrovascular dysfunction. [PMID:39892386]	Vandal M, Institoris A, Reveret L, Korin	Neuron	2025	1
Protective genetic variants against Alzheimer's disease. [PMID:40409316]	Marino C, Malotaux V, Giudicessi A, Agui	Lancet Neurol	2025	1
Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional [PMID:39232006]	Serafin DS, Harris NR, Bálint L, Douglas	Nat Commun	2024	1
Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Devel [PMID:32604886]	Jossin Y	Biomolecules	2020	1
Neuronal migration. [PMID:11429281]	Lambert de Rouvroit C, Goffinet AM	Mech Dev	2001	1
Modulation of apolipoprotein E receptor-2 by ApoE4, amyloid β-peptide, reelin, a [PMID:41858499]	["Barger S", "Moerman-Herzog A"]	Frontiers in molecular neurosc	2026	0
The Potential Molecular Mechanisms and Key Genes of Early Deterioration of Paren [PMID:41863408]	["Cen G", "Li J", "Wang J", "Chen Y", "L	Current neurovascular research	2026	0
RELN biallelic variant as a candidate risk factor in a consanguineous Pakistani [PMID:41785923]	["Hashmi A", "Harripaul R", "Muhammad T"	Journal of affective disorders	2026	0
Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052]	Burdman Gabriel; Akkaoui Juliet; Colon N	Neurology international	2026	0
Temporal and Spatial Gene Expression Dynamics in Neonatal HI Hippocampus with Fo [PMID:41677619]	["Smith M", "Natarajan E", "Lizama-Valen	Cells	2026	0
Migration of dI5 Reelin-Lmx1b-Zfhx3 and Disabled-1-Lmx1b-Zfhx3 neurons contribut [PMID:41890024]	["Yvone G", "Chavez-Martinez C", "Mekonn	bioRxiv : the preprint server	2026	0
Whisking Behaviour Reveals Stronger Evidence of Habituation in Homozygous Reeler [PMID:41844513]	["Simanaviciute U", "Cetin A", "Guy J",	Genes, brain, and behavior	2026	0
Reln haploinsufficiency enhances fentanyl-induced locomotion and striatal activi [PMID:41890027]	["Litif C", "Libster A", "Desfor S", "Hu	bioRxiv : the preprint server	2026	0
Immunoglobulin allotypes and [PMID:41848375]	["Pandey J", "Namboodiri A", "Nietert P"	Journal of Alzheimer's disease	2026	0
Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, [PMID:41893052]	["Burdman G", "Akkaoui J", "Colon N", "P	Neurology international	2026	0
Genetic or therapeutic disruption of the Reelin/Apoer2 signaling pathway improve [PMID:40073057]	["Calvier L", "Wasser C", "Solow E", "Wu	Proceedings of the National Ac	2025	0
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheime [PMID:41035073]	Castanho I, Naderi Yeganeh P, Boix CA, M	Molecular neurodegeneration	2025	0
Glutamatergic argonaute2 promotes the formation of the neurovascular unit in mic [PMID:39999211]	Sona C, Yeh YT, Li Y, Liu X, Ghosh A, Hi	Science signaling	2025	0
APOE deficiency inhibits amyloid-facilitated (A) tau pathology (T) and neurodege [PMID:40307424]	["Vanherle S", "Janssen A", "Guti\u00e9r	Molecular psychiatry	2025	0
Protective Genes Against Alzheimer's Disease: Case Review and Therapeutic Implic [PMID:40321438]	Hossain N, Jeong Y	Dementia and neurocognitive di	2025	0

Debates (1)

Multi-agent debates referencing this entity

Why do entorhinal cortex layer II stellate neurons die first in AD? Their unique

closed · Rounds: 6 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning RELN in their description or question text

No additional research found