SIGMAR1

Understanding Entity Pages

This page aggregates everything SciDEX knows about SIGMAR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

SIGMAR1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, biomarker for. Associated with Als, Amyotrophic Lateral Sclerosis, Inflammation. Connected to 67 entities in the SciDEX knowledge graph.

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graph TD
    SIGMAR1["SIGMAR1"]
    Lymphoma{"Lymphoma"}
    SIGMAR1 -->|"associated with"| Lymphoma
    Ms{"Ms"}
    SIGMAR1 -->|"associated with"| Ms
    Inflammation{"Inflammation"}
    SIGMAR1 -->|"associated with"| Inflammation
    Als{"Als"}
    SIGMAR1 -->|"regulates"| Als
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    SIGMAR1 -->|"biomarker for"| Amyotrophic_Lateral_Sclerosis
    MYD88["MYD88"]
    SIGMAR1 -->|"associated with"| MYD88
    PUMA["PUMA"]
    SIGMAR1 -->|"associated with"| PUMA
    Toll_Like_Receptor(["Toll-Like Receptor"])
    SIGMAR1 -->|"associated with"| Toll_Like_Receptor
    Oxidative_Stress(["Oxidative Stress"])
    SIGMAR1 -->|"associated with"| Oxidative_Stress
    Autophagy(["Autophagy"])
    SIGMAR1 -->|"associated with"| Autophagy
    Pi3K(["Pi3K"])
    SIGMAR1 -->|"associated with"| Pi3K
    Apoptosis(["Apoptosis"])
    SIGMAR1 -->|"associated with"| Apoptosis
    VEGF["VEGF"]
    VEGF -->|"associated with"| SIGMAR1
    BAX["BAX"]
    BAX -->|"associated with"| SIGMAR1
    FIS1["FIS1"]
    FIS1 -->|"associated with"| SIGMAR1
    TRAF6["TRAF6"]
    TRAF6 -->|"associated with"| SIGMAR1
    CHOP["CHOP"]
    CHOP -->|"associated with"| SIGMAR1
    NRF2["NRF2"]
    NRF2 -->|"associated with"| SIGMAR1
    MTOR["MTOR"]
    MTOR -->|"associated with"| SIGMAR1
    BECLIN1["BECLIN1"]
    BECLIN1 -->|"associated with"| SIGMAR1
    BCL2["BCL2"]
    BCL2 -->|"associated with"| SIGMAR1
    TAAR1["TAAR1"]
    TAAR1 -->|"associated with"| SIGMAR1
    PI3K["PI3K"]
    PI3K -->|"associated with"| SIGMAR1
    MYD88 -->|"associated with"| SIGMAR1
    style SIGMAR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

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