protein

FIS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FIS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

362Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FIS1 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Aging, Als, Alzheimer. Connected to 232 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	FIS1
Full Name	Fission 1 Mitochondrial Outer Membrane Protein
Chromosome	7q22.1
Protein Type	Mitochondrial outer membrane protein
Function	Fis1 Gene plays an important role in the study of neurodegenerative diseases
Molecular Weight	17 kDa
Pathways	Apoptosis, Autophagy, Lysosomal Degradation, Mitochondrial Function, Mitophagy
GeneCards	FIS1
Human Protein Atlas	FIS1
Associated Diseases	Aging, Als, Cardiomyopathy, Inflammation, Lymphoma
Known Drugs/Compounds	RAPAMYCIN
Interactions	AGING, AMPK, AND, APP, ATP, AUTOPHAGY
KG Connections	362 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FIS1["FIS1"]
    FIS1 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    FIS1 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    FIS1 -->|"regulates"| Inflammation["Inflammation"]
    FIS1 -->|"regulates"| Glioblastoma["Glioblastoma"]
    FIS1 -->|"interacts"| Dementia["Dementia"]
    FIS1 -->|"interacts"| Als["Als"]
    FIS1 -->|"interacts"| Ms["Ms"]
    MFF["MFF"] -->|"activates"| FIS1
    DNM1L["DNM1L"] -->|"target for"| FIS1
    LC3B["LC3B"] -->|"interacts"| FIS1
    MICROGLIA["MICROGLIA"] -->|"interacts"| FIS1
    MFN2["MFN2"] -->|"activates"| FIS1
    CCR5["CCR5"] -->|"interacts"| FIS1
    APP["APP"] -->|"interacts"| FIS1
    DRP1["DRP1"] -->|"regulates"| FIS1
    MFN1["MFN1"] -->|"regulates"| FIS1

Outgoing (224)

Target	Relation	Type	Str
Mitochondrial Fragmentation	mediates	process	0.85
Als	activates	disease	0.75
Inflammation	activates	disease	0.75
Mitophagy	activates	pathway	0.70
MITOPHAGY	activates	gene	0.70
Cardiac	inhibits	disease	0.65
Obesity	activates	disease	0.65
Sepsis	interacts_with	disease	0.65
Diabetes	regulates	disease	0.65
Aging	inhibits	disease	0.65
Retinopathy	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Pyroptosis	causes	disease	0.65
Atherosclerosis	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Infection	activates	disease	0.65
Obesity	regulates	disease	0.65
Ms	regulates	disease	0.65
Cardiomyopathy	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Lymphoma	associated_with	disease	0.65
Glioblastoma	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Cancer	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Stroke	regulates	disease	0.65
Dementia	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Ischemia	regulates	disease	0.65
Hypertension	regulates	disease	0.65
Aging	causes	disease	0.65
Ms	therapeutic_target	disease	0.65
Neuroinflammation	regulates	disease	0.65
MITOCHONDRIAL_FRAGMENTATION	regulates	phenotype	0.64
Mitophagy	inhibits	pathway	0.60
Mitophagy	therapeutic_target	pathway	0.60
MFF	activates	gene	0.60
Mitochondrial Function	activates	pathway	0.60
HO-1	associated_with	gene	0.60
P53	associated_with	gene	0.60

Incoming (138)

Source	Relation	Type	Str
PM10	upregulates	compound	0.85
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.70
BAX	associated_with	gene	0.60
FUNDC1	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
TNF	associated_with	gene	0.60
DRP1	inhibits	gene	0.60
MFF	regulates	gene	0.60
PRKDC	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
VEGF	associated_with	gene	0.60
MITOPHAGY	regulates	gene	0.60
ATP	activates	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
LYSOSOME	regulates	gene	0.60
NAD	regulates	gene	0.60
AND	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
C-MYC	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
NOX	associated_with	gene	0.60
MICROGLIA	interacts_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
AND	inhibits	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AND	associated_with	gene	0.60
NUPR1	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
MYD88	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
NRF2	associated_with	gene	0.60
AKT	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
TAAR1	associated_with	gene	0.60
TRAF6	associated_with	gene	0.60
MFF	activates	gene	0.60
DNM1L	therapeutic_target	gene	0.60
DNM1L	inhibits	gene	0.60
MFN2	activates	gene	0.60
CCR5	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
DRP1	associated_with	gene	0.60
MID49	associated_with	gene	0.60
MFF	associated_with	gene	0.60
MID51	associated_with	gene	0.60
DRP1	regulates	gene	0.60
MFN1	regulates	gene	0.60
NRF1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FIS1 in their description or question text

No additional research found