gene

TGFB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGFB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

206Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	TGFB
Pathways	Mitophagy, Autophagy, Epithelial-Mesenchymal Transition, Apoptosis, Tgf-Β
GeneCards	TGFB
Human Protein Atlas	TGFB
Associated Diseases	Als, Fibrosis, Parkinson, Renal Fibrosis, TUMOR_FIBROSIS
Known Drugs/Compounds	rapamycin
Interactions	AKT, AND, APOPTOSIS, ATG, AUTOPHAGY, BNIP3
KG Connections	206 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (13)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TGFB["TGFB"] -->|"causes"| Fibrosis["Fibrosis"]
    TGFB["TGFB"] -->|"activates"| MYCAFS["MYCAFS"]
    TGFB["TGFB"] -->|"activates"| Mitophagy["Mitophagy"]
    TGFB["TGFB"] -->|"activates"| Chronic_Kidney_Disease["Chronic Kidney Disease"]
    TGFB["TGFB"] -->|"activates"| Fibrosis_1["Fibrosis"]
    TGFB["TGFB"] -->|"activates"| Inflammation["Inflammation"]
    MITOPHAGY["MITOPHAGY"] -->|"activates"| TGFB["TGFB"]
    PLASMIN["PLASMIN"] -->|"activates"| TGFB["TGFB"]
    MPXV["MPXV"] -->|"regulates"| TGFB["TGFB"]
    SMAD2["SMAD2"] -->|"expressed in"| TGFB["TGFB"]
    style TGFB fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (75)

Target	Relation	Type	Str
Renal Fibrosis	causes	disease	0.90
renal fibrosis	promotes	disease	0.85
Fibrosis	causes	disease	0.80
MYCAFS	activates	cell_type	0.72
Mitophagy	activates	pathway	0.70
Als	associated_with	disease	0.65
Fibrosis	activates	disease	0.65
Inflammation	activates	disease	0.65
Chronic Kidney Disease	activates	disease	0.65
Parkinson	associated_with	disease	0.65
OSTEOCLAST	activates	cell_type	0.64
TUMOR_FIBROSIS	causes	phenotype	0.64
ADAM17	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
SMAD2	activates	protein	0.60
SMAD3	activates	protein	0.60
USH2A	associated_with	gene	0.60
TP53	activates	gene	0.60
Alzheimer's disease	activates	disease	0.60
Parkinson's disease	activates	disease	0.60
senescence	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
IL6	associated_with	gene	0.60
ANGPTL4	associated_with	gene	0.60
SMAD2	expressed_in	gene	0.60
MAP1LC3	expressed_in	gene	0.60
SQSTM1	expressed_in	gene	0.60
AND	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
PINK1	expressed_in	gene	0.60
NIX	activates	gene	0.60
SMAD4	regulates	gene	0.60
LC3	activates	gene	0.60
GENES	activates	gene	0.60
TGFB1	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
BNIP3L	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Akt	activates	pathway	0.60
MAP1LC3	activates	gene	0.60
PARKIN	expressed_in	gene	0.60
Autophagy	activates	pathway	0.60
Epithelial-Mesenchymal Transition	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Tgf-Β	expressed_in	pathway	0.60
NBR1	associated_with	gene	0.60

Incoming (131)

Source	Relation	Type	Str
MITOPHAGY	activates	gene	0.70
MPXV	regulates	disease	0.64
PLASMIN	activates	protein	0.64
CDKN1A	activates	gene	0.60
CDKN2A	activates	gene	0.60
DMSO	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
GLB1	activates	gene	0.60
MKI67	activates	gene	0.60
MTOR	activates	gene	0.60
PCNA	activates	gene	0.60
PI3K	activates	gene	0.60
PIK3CA	activates	gene	0.60
PSMA1	activates	gene	0.60
PSMB5	activates	gene	0.60
RPS6KB1	activates	gene	0.60
SMAD	activates	gene	0.60
rapamycin	targets	drug	0.60
TGF	activates	gene	0.60
ROS	activates	gene	0.60
ATG	activates	gene	0.60
SMAD2	regulates	gene	0.60
BNIP3	activates	gene	0.60
FUNDC1	activates	gene	0.60
SMAD3	regulates	gene	0.60
PINK1	expressed_in	gene	0.60
AUTOPHAGY	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
SQSTM1	expressed_in	gene	0.60
MAP1LC3	expressed_in	gene	0.60
P62	expressed_in	gene	0.60
OPTINEURIN	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
INS	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
SMAD2	expressed_in	gene	0.60
ANGPTL4	associated_with	gene	0.60
AKT	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
PRKN	expressed_in	gene	0.60
AND	activates	gene	0.60
PARKIN	expressed_in	gene	0.60
LC3	expressed_in	gene	0.60
SMAD3	expressed_in	gene	0.60
NFKB	associated_with	gene	0.60
PARK2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TGFB in their description or question text

No additional research found

TGFB

Understanding Entity Pages

Wiki Pages (13)

TGFBI

TGFBR2 Protein — Transforming Growth Factor Beta Receptor 2

TGFB2 Gene

TGFBR1 — Transforming Growth Factor Beta Receptor 1

TGFBR2 — Transforming Growth Factor Beta Receptor 2

TGFB2 Protein

TGFB3 Gene

TGF-β Receptor 2 (TGFBR2) Protein

TGF-β Receptor 1 (TGFBR1) Protein

TGFB1 — Transforming Growth Factor Beta 1

TGFB3 Protein

TGFBR2 (Transforming Growth Factor Beta Receptor 2)

TGFBR1 — TGF-beta Receptor 1