gene

TGFB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGFB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

753Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

TGFB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with ALS, Aging, Als. Connected to 297 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TGFB1
Full Name	Transforming Growth Factor Beta 1
Chromosome	19q13.2
Protein Type	Ligand
Target Class	Ligand
Function	encodes Transforming Growth Factor Beta 1, a key cytokine with complex roles in neuroinflammation, neuroprotection, and synaptic plasticity
Mechanism of Action	Monoclonal antibodies neutralizing TGF-β1 or small molecule inhibitors of TGF-β signaling
Druggability	Low (0.44)
Clinical Stage	Phase III
Amino Acids	390 aa
Gene Type	Protein coding
Pathways	Autophagy, Immune Response, Mtor, Tgf-Β
UniProt ID	P01137
Ensembl ID	ENSG00000127616
GeneCards	TGFB1
Human Protein Atlas	TGFB1
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Cancer
Known Drugs/Compounds	curcumin, resveratrol
Interactions	ACTB, AHR, AHSA1, ALZHEIMER, AND, APP
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	753 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TGFB1 — AlphaFold P01137 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TGFB1 — Transforming Growth Factor Beta 1

gene · 769 words

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Pathway Diagram

graph TD
    TGFB1["TGFB1"] -->|"interacts"| AHR["AHR"]
    TGFB1["TGFB1"] -->|"interacts"| IL10["IL10"]
    TGFB1["TGFB1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    TGFB1["TGFB1"] -->|"interacts"| FOXP3["FOXP3"]
    AHR_1["AHR"] -->|"interacts"| TGFB1["TGFB1"]
    IL10_2["IL10"] -->|"interacts"| TGFB1["TGFB1"]
    FOXP3_3["FOXP3"] -->|"co discussed"| TGFB1["TGFB1"]
    TNFA["TNFA"] -->|"co discussed"| TGFB1["TGFB1"]
    style TGFB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (398)

Target	Relation	Type	Str
Hepatic Stellate Cells	activates	cell_type	0.95
Fibrosis	contributes_to	disease	0.95
Hsc Activation	mediates	process	0.93
Vascular Remodelling	involved_in	process	0.90
pulmonary artery smooth muscle cell proliferation	promotes	process	0.90
fibrosis	promotes	process	0.90
Tumor Fibrosis	associated_with	phenotype	0.90
HSC Activation	mediates	process	0.90
Cancer-Associated Fibroblasts	activates	cell_type	0.90
extracellular vesicles	expressed_in	cell_type	0.90
mitophagy	activates	pathway	0.90
kidney fibrosis	promotes	phenotype	0.90
Liver Fibrosis	contributes_to	disease	0.90
EMT	enhances	pathway	0.90
Hepatic Stellate Cell	activates	cell_type	0.88
Hsc Cell Line	activates	cell_type	0.88
Fibroblast Activation	promotes	process	0.88
angiogenesis	promotes	process	0.85
Myofibroblasts	associated_with	cell_type	0.85
MICROGLIA	upregulates	cell_type	0.85
senescence	regulates	process	0.85
Cellular Senescence	regulates	phenotype	0.85
Type 2 Diabetes Mellitus	biomarker_for	disease	0.82
Osimertinib resistance	enhances	disease	0.80
Fibrosis	causes	disease	0.80
EGR1	activates	protein	0.80
PLSCR3	activates	protein	0.80
myofibroblasts	regulates	cell_type	0.80
CCN2	regulates	gene	0.80
Ischemic Heart Disease	biomarker_for	disease	0.79
Pulmonary Arterial Hypertension	involved_in	disease	0.75
FOXP3(lo) non-Treg cells	promotes	cell_type	0.75
Tumor	associated_with	disease	0.75
Cancer	associated_with	disease	0.75
Inflammation	regulates	disease	0.75
Als	activates	disease	0.75
Inflammation	associated_with	disease	0.75
Als	associated_with	disease	0.75
MAP1LC3B	associated_with	gene	0.70
IL10	associated_with	gene	0.70
TREGS	activates	cell_type	0.70
Autophagy	associated_with	pathway	0.70
AUTOPHAGY	associated_with	gene	0.70
ATG	associated_with	gene	0.70
Cancer	expressed_in	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	implicated_in	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65

Incoming (355)

Source	Relation	Type	Str
FOXO1	upregulates	gene	0.92
FOXO1	mediates	gene	0.90
HIF-1Α	upregulates	gene	0.90
Necroinflammation	upregulates	process	0.90
h-6a065252	targets_gene	hypothesis	0.90
h-f9c6fa3f	targets_gene	hypothesis	0.90
PLG	activates	protein	0.85
Plasmin Activation	activates	process	0.85
high glucose	upregulates	compound	0.85
Hepatocyte	expressed_in	cell_type	0.85
h-6a065252	targets	hypothesis	0.80
METHIONINE RESTRICTION	inhibits	biological_process	0.80
h-f9c6fa3f	targets	hypothesis	0.80
AHSA1-HSP90AA1 complex	associated_with	gene	0.80
TNF	associated_with	gene	0.80
mesenchymal stem cell	associated_with	cell_type	0.75
MIRNAS	therapeutic_target	gene	0.70
GENES	associated_with	gene	0.70
ATG	associated_with	gene	0.70
TAU	associated_with	gene	0.65
GSK3B	associated_with	gene	0.65
C1QR	activates	protein	0.64
APP	therapeutic_target	gene	0.60
IGF1R	therapeutic_target	gene	0.60
GSK3B	therapeutic_target	gene	0.60
MMP2	therapeutic_target	gene	0.60
ESR1	therapeutic_target	gene	0.60
TAU	therapeutic_target	gene	0.60
CD200	associated_with	gene	0.60
NOS2	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
CDKN2A	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
CDKN1A	regulates	gene	0.60
P62	regulates	gene	0.60
BECN1	associated_with	gene	0.60
SMAD2	activates	gene	0.60
FUNDC1	activates	gene	0.60
SMAD3	activates	gene	0.60
AKT	therapeutic_target	gene	0.60
FOXP3	regulates	gene	0.60
PI3K	therapeutic_target	gene	0.60
CD4	regulates	gene	0.60
CDK5	therapeutic_target	gene	0.60
STAT3	implicated_in	gene	0.60
STING	associated_with	gene	0.60
JUNB	activates	gene	0.60
SIRT1	associated_with	gene	0.60
HSP90AA1	implicated_in	gene	0.60
CD8	therapeutic_target	gene	0.60